Author details

Full Name

Melvin E Andersen

Affiliation

ORCID

Career Start Year

1971

Papers

447

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36596351	Incorporation of a recirculating mobile lipid pool description into the cyclic volatile siloxane (cVMS) PBPK model captures terminal clearance of D after repeated inhalation exposure in F344 and SD Rats.		2023
36523256	Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity.		2023
36912747	Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat.		2023
36453847	Incorporation of rapid association/dissociation processes in tissues into the monkey and human physiologically based pharmacokinetic models for manganese.	Toxicological Sciences	2023
34929594	The genotoxic potential of mixed nitrosamines in drinking water involves oxidative stress and Nrf2 activation.		2022
36183849	NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene.	Toxicology	2022
36278238	Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods.	Frontiers in Pharmacology	2022
34990717	Single enrichment systems possibly underestimate both exposures and biological effects of organic pollutants from drinking water.		2022
34857443	Corrigendum to "Regulatory role of KEAP1 and NRF2 in PPARg expression and chemoresistance in human non-small-cell lung carcinoma cells" [Free Radic Biol Med. 53 (2012) 758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7. PMID: 22684020].	Free Radical Biology and Medicine	2022
34425169	Time-dependent genomic response in primary human uroepithelial cells exposed to arsenite for up to 60 days.	Toxicology	2021
34174380	A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidozole.	Regulatory Toxicology and Pharmacology	2021
33631233	Integration of paraquat pharmacokinetic data across species using PBPK modelling.	Toxicology and Applied Pharmacology	2021
33887277	Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures.	Environmental Research	2021
34246716	Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms.	Toxicology	2021
34660856	RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days.	Data in Brief	2021
32900235	Response to "letter concerning: Clewell (2019) incorporation of metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene." (UIHT-2020-0053).	Inhalation Toxicology	2020
31901728	Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARÎ³ expression.	Redox Biology	2020
32360442	Derivation of whole blood biomonitoring equivalents for titanium for the interpretation of biomonitoring data.	Regulatory Toxicology and Pharmacology	2020
31783037	The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay.	Toxicology and Applied Pharmacology	2020
31728591	Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver.	Arch Toxicol	2020
31628012	Identifying qualitative differences in PPARÎ± signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods.	Toxicology in Vitro	2020
31881176	A toxicogenomic approach for the risk assessment of the food contaminant acetamide.	Toxicol Appl Pharmacol	2020
31935483	Derivation of whole blood biomonitoring equivalents for lithium for the interpretation of biomonitoring data.	Regulatory Toxicology and Pharmacology	2020
32049351	Consideration of Styrene Transcriptomic Data Informs Mouse Lung Cyp2F2-Mediated Adverse Outcome Pathway.	Toxicological Sciences	2020
31931283	Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARÎ³ expression.	Redox Biology	2020
32278033	Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.	Toxicology in Vitro	2020
32735340	A Kinetic Analysis of DNA-Deoxy Guanine Adducts in the Nasal Epithelium Produced by Inhaled Formaldehyde in Rats-Assessing Contributions to Adduct Production From Both Endogenous and Exogenous Sources of Formaldehyde.	Toxicological Sciences	2020
31394159	Assessing children's exposure to manganese in drinking water using a PBPK model.	Toxicology and Applied Pharmacology	2019
31992090	Incorporation of metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.	Inhalation Toxicology	2019
31768481	Embracing Systems Toxicology at Single-Cell Resolution.		2019
31664457	Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).	Altex	2019
30218698	Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.	Toxicology in Vitro	2019
30978397	Updating physiologically based pharmacokinetic models for manganese by incorporating rapid association/dissociation processes in tissues.	Toxicology and Applied Pharmacology	2019
30807807	Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures.	Toxicology in Vitro	2019
31059732	Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop.	Regulatory Toxicology and Pharmacology	2019
29777725	Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment.	Regulatory Toxicology and Pharmacology	2018
29935181	Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice.	Biochem Biophys Res Commun	2018
30243844	Physiologically-based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water.	Toxicology and Applied Pharmacology	2018
30140178	Enhancing and Extending Biological Performance and Resilience.	Dose Response	2018
30333746	A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation.	Frontiers in Pharmacology	2018
29391263	Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.	Toxicology in Vitro	2018
29496518	Based on an analysis of mode of action, styrene-induced mouse lung tumors are not a human cancer concern.	Regulatory Toxicology and Pharmacology	2018
27664422	Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis.	Toxicological Sciences	2017
28392392	Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver.	Toxicology and Applied Pharmacology	2017
28392065	Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use.	Environment international	2017
28951217	Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures.	Toxicology and Applied Pharmacology	2017
28675057	Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts.	Critical Reviews in Toxicology	2017
28408153	Refinement of the oral exposure description in the cyclic siloxane PBPK model for rats and humans: Implications for exposure assessment.	Toxicology Letters	2017
28962520	Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2â¿¿Years Supports a Lack of Human Relevance.	Toxicological Sciences	2017
28237878	A tissue dose-based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling-The importance of homeostatic control for an essential metal.	Toxicology and Applied Pharmacology	2017