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Author Details

Paul C Driscoll
The Francis Crick Institute
1987
139
46
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37245210ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis.Cell Rep2023
33452240Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells.Nat Commun2021
34702840The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells.Nat Commun2021
32694609Identifying strategies to target the metabolic flexibility of tumours.Nat Metab2020
30697004Reply to 'Do sulfate radicals really enable a non-enzymatic Krebs cycle precursor?'Nat Ecol Evol2019
31645751Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.Nat Chem Biol2019
31264961Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation.Elife2019
30757904An Improved Method for Measuring Absolute Metabolite Concentrations in Small Biofluid or Tissue Samples.J Proteome Res2019
30297875MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.Nat Chem Biol2018
29972810Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.Biophys J2018
28630053Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.Cancer Res2017
29123106Developmental diet regulates Drosophila lifespan via lipid autotoxins.Nat Commun2017
28652321Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice.Proc Natl Acad Sci U S A2017
28715126An engineered photoswitchable mammalian pyruvate kinase.FEBS J2017
27100463Mechanism of Action of Secreted Newt Anterior Gradient Protein.PLoS One2016
27253369Measuring IgA Anti-β2-Glycoprotein I and IgG/IgA Anti-Domain I Antibodies Adds Value to Current Serological Assays for the Antiphospholipid Syndrome.PLoS One2016
25273993Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis.Rheumatology (Oxford)2015
26116243Exposed: The Many and Varied Roles of Phospholipase C γ SH2 Domains.J Mol Biol2015
25528640Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry.J Mol Biol2015
24484052Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase.Biochemistry2014
25065892Structural studies of death receptors.Methods Enzymol2014
23228652Targeting VEGF signalling via the neuropilin co-receptor.Drug Discov Today2013
24251761Volume determination with two standards allows absolute quantification and improved chemometric analysis of metabolites by NMR from submicroliter samples.Anal Chem2013
23922916Structural and functional characterization of the recombinant death domain from death-associated protein kinase.PLoS One2013
22484176Characterization of Vibrio cholerae Hfq provides novel insights into the role of the Hfq C-terminal region.J Mol Biol2012
22955930In support of the BMRB.Nat Struct Mol Biol2012
23063561Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation.Structure2012
21446842A combinatorial method to enable detailed investigation of protein-protein interactions.Future Med Chem2011
21816278Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila.Cell2011
21899894Evaluating the conformation of recombinant domain I of β(2)-glycoprotein I and its interaction with human monoclonal antibodies.Mol Immunol2011
19886864Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I).Biochem J2010
21558221Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders.Integr Comp Biol2010
20947025Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus.Structure2010
20151671Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.J Med Chem2010
20118254Structural homology between the C-terminal domain of the PapC usher and its plug.J Bacteriol2010
19531496Characterization of phospholipase C gamma enzymes with gain-of-function mutations.J Biol Chem2009
19771161Solution structure and phylogenetics of Prod1, a member of the three-finger protein superfamily implicated in salamander limb regeneration.PLoS One2009
18339402Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5.J Mol Biol2008
18728011rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain.J Biol Chem2008
18495154Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b.J Mol Biol2008
18312637Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding.BMC Struct Biol2008
18245374Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.Genetics2008
17244707NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system.Proc Natl Acad Sci U S A2007
19636824Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.Biomol NMR Assign2007
17993412DNA fragmentation based combinatorial approaches to soluble protein expression Part II: library expression, screening and scale-up.Drug Discov Today2007
17993411DNA fragmentation-based combinatorial approaches to soluble protein expression Part I. Generating DNA fragment libraries.Drug Discov Today2007
17599096Biophysical and cell-based evidence for differential interactions between the death domains of CD95/Fas and FADD.Cell Death Differ2007
17318838RILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family.Hum Mutat2007
16601857Resonance assignments of the complex between TraN and the C-terminal domain of TraO from the conjugative plasmid pKM101.J Biomol NMR2006
17008718Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.Protein Sci2006
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Collaborators

Iain D Campbell
University of Oxford
Co-authored papers 16
Angela M Gronenborn
University of Pittsburgh
Co-authored papers 12
Mark Pfuhl
King's College London
Co-authored papers 7
John E Ladbury
University of Leeds
Co-authored papers 5
Helen R Mott
University of Cambridge
Co-authored papers 4
Jason G Cyster
University of California san francisco
Co-authored papers 3
Yiannis Ioannou
Co-authored papers 3
Ad Bax
National Institutes of Health
Co-authored papers 3
Fernando Rodrigues-Lima
Universite Paris Cite, CNRS
Co-authored papers 2
David I Stuart
University of Oxford
Co-authored papers 2
Markus Ralser
Charite - Universitatsmedizin Berlin
Co-authored papers 2
Julie D Forman-Kay
Hospital for Sick Children
Co-authored papers 2
Carol V Robinson
University of Oxford
Co-authored papers 2
Cyril H Benes
Co-authored papers 2
Lewis E Kay
University of Toronto
Co-authored papers 2
Paul N Barlow
University of Edinburgh
Co-authored papers 1
Kate Bushby
Institute of Genetic Medicine, International Centre for Life
Co-authored papers 1
David A Case
Rutgers University
Co-authored papers 1
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Gordon C K Roberts
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
Josep Rizo
University of Texas Southwestern Medical Center
Co-authored papers 1
Mike P Williamson
The University of Sheffield
Co-authored papers 1
Lu-Yun Lian
Institute of Systems, The University of Liverpool
Co-authored papers 1
Chris P Ponting
The University of Edinburgh
Co-authored papers 1
Igor L Barsukov
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
David E Shaw
Columbia University
Co-authored papers 1
Robert C Stein
12 University College London Hospitals National Health Service Foundation Trust
Co-authored papers 1
Patrick C A van der Wel
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
David Middleton
Co-authored papers 1
Ioannis Vakonakis
University of Oxford
Co-authored papers 1
Release 1.2