Author details

Full Name

Daniela Rotin

Affiliation

The Hospital for Sick Children

ORCID

Career Start Year

1982

Papers

127

H Index

Expertise

CM4AI Collaborator

Nevan J Krogan (CM4AI)

PMID	Paper Title	Journal Title	Published Year
38032389	Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.	J Cell Biol	2024
37962894	Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.	Physiology (Bethesda)	2024
37863970	Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding.	Sci Rep	2023
36008477	Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases.	Sci Rep	2022
35858421	Elevated intracellular Na<sup>+</sup> and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2.	Proc Natl Acad Sci U S A	2022
34061979	Function and Regulation of the Epithelial Na<sup>+</sup> Channel ENaC.	Compr Physiol	2021
33911160	Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells.	Sci Rep	2021
34943927	High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids.	Cells	2021
34599943	Split Chloramphenicol Acetyl-Transferase Assay Reveals Self-Ubiquitylation-Dependent Regulation of UBE3B.	J Mol Biol	2021
32332792	Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.	Nat Commun	2020
32650630	Phosphorylation of the Chaperone-Like HspB5 Rescues Trafficking and Function of F508del-CFTR.	Int J Mol Sci	2020
30518551	Regulation of SH3PX1 by dNedd4-long at the <i>Drosophila</i> neuromuscular junction.	J Biol Chem	2019
31067471	The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1.	Cell Rep	2019
29150487	Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin.	J Cell Sci	2018
28069708	Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.	EMBO J	2017
28087701	The Ubiquitin Ligase Nedd4L Regulates the Na/K/2Cl Co-transporter NKCC1/SLC12A2 in the Colon.	J Biol Chem	2017
28539224	Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice.	J Cyst Fibros	2017
26949039	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	Mol Cell	2016
27086928	Intestinal knockout of Nedd4 enhances growth of Apc<sup>min</sup> tumors.	Oncogene	2016
26823013	Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation.	Mol Biol Cell	2016
24974227	Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.	J Cyst Fibros	2015
25825526	RNA Interference Screen to Identify Kinases That Suppress Rescue of Î¿F508-CFTR.	Mol Cell Proteomics	2015
25998567	LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.	Nat Commun	2015
24385580	Protein tyrosine phosphatase Ï¿ targets apical junction complex proteins in the intestine and regulates epithelial permeability.	Proc Natl Acad Sci U S A	2014
25292214	Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.	Sci Signal	2014
25344756	Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.	Nat Cell Biol	2014
25157163	Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.	Proc Natl Acad Sci U S A	2014
23287719	A strategy for modulation of enzymes in the ubiquitin system.	Science	2013
23455478	Ubiquitylation-dependent localization of PLK1 in mitosis.	Nat Cell Biol	2013
22737130	Nedd4-2 and the regulation of epithelial sodium transport.	Front Physiol	2012
23110050	The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice.	PLoS One	2012
22733818	LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages.	J Biol Chem	2012
22700489	Use of kinase inhibitors to correct Î¿F508-CFTR function.	Mol Cell Proteomics	2012
20972579	Role of the ubiquitin system in regulating ion transport.	Pflugers Arch	2011
22110599	A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila.	PLoS One	2011
22096579	A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.	PLoS One	2011
21863490	Use of proteome arrays to globally identify substrates for E3 ubiquitin ligases.	Methods Mol Biol	2011
21765395	Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.	EMBO J	2011
21300902	Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.	Proc Natl Acad Sci U S A	2011
20026598	The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.	J Biol Chem	2010
20646264	Regulation of lipid droplet turnover by ubiquitin ligases.	BMC Biol	2010
20200141	Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.	Mol Pharmacol	2010
19088066	High-content functional screen to identify proteins that correct F508del-CFTR function.	Mol Cell Proteomics	2009
19953087	Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.	Mol Syst Biol	2009
19436320	Physiological functions of the HECT family of ubiquitin ligases.	Nat Rev Mol Cell Biol	2009
19398441	Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease.	Gut	2009
19477416	Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs.	Chem Biol	2009
19506287	Health care crisis in Gaza.	CMAJ	2009
18680311	Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.	Biochemistry	2008
19007435	Role of the UPS in Liddle syndrome.	BMC Biochem	2008

1 - 50 of 127

Ganesh Pathare

Institute of Anatomy, University of Zurich

Career Start Year 2011

Number of shared co-authors 0

Florent Dingli

Institut Curie, PSL Research University

Career Start Year 2011

Number of shared co-authors 0

Su Sien Ong

St. Jude Children's Research Hospital

Career Start Year 2008

Number of shared co-authors 1

Hyun Woo Park

College of Life Science and Biotechnology, Yonsei University

Career Start Year 2006

Number of shared co-authors 0

Ana Velic

Interfaculty Institute for Cell Biology.

Career Start Year 2003

Number of shared co-authors 0

Jayantha Gunaratne

Institute of Molecular and Cell Biology

Career Start Year 2000

Number of shared co-authors 0

Jeroen A A Demmers

Erasmus Medical Center

Career Start Year 2000

Number of shared co-authors 1

Jonathan C Trinidad

Indiana University

Career Start Year 2000

Number of shared co-authors 2

Guang Lin

Baylor College of Medicine

Career Start Year 1999

Number of shared co-authors 0

Matias Simons

Institute of Human Genetics, University Hospital Heidelberg

Career Start Year 1999

Number of shared co-authors 3

Yan Liu

Chengdu Medical College

Career Start Year 1999

Number of shared co-authors 0

Paul Taylor

Hospital for Sick Children

Career Start Year 1999

Number of shared co-authors 10

An-Chi Tien

Barrow Neurological Institute, St. Joseph's Hospital & Medical Center

Career Start Year 1999

Number of shared co-authors 0

Rachel Toth

University of Dundee

Career Start Year 1999

Number of shared co-authors 4

Stephane Angers

Department of Pharmaceutical Sciences, University of Toronto

Career Start Year 1999

Number of shared co-authors 9

Rasmus Hartmann-Petersen

University of Copenhagen

Career Start Year 1998

Number of shared co-authors 1

Ashok K Pullikuth

Wake Forest University School of Medicine

Career Start Year 1997

Number of shared co-authors 0

Damarys Loew

Institut Curie, PSL Research University

Career Start Year 1996

Number of shared co-authors 0

Ning Zheng

University of Washington

Career Start Year 1996

Number of shared co-authors 1

Jose Antonio Rodriguez

University of the Basque Country (UPV/EHU)

Career Start Year 1995

Number of shared co-authors 1

Meng-Qiu Dong

National Institute of Biological Sciences

Career Start Year 1995

Number of shared co-authors 0

Anne-Claude Gingras

Lunenfeld-Tanenbaum Research Institute

Career Start Year 1994

Number of shared co-authors 20

Ailan Guo

College of Animal Medicine, Xinjiang Agricultural University

Career Start Year 1992

Number of shared co-authors 5

Ivan Dikic

Institute of Biochemistry II, Goethe University Frankfurt

Career Start Year 1992

Number of shared co-authors 5

Dirk Geerts

Amsterdam University Medical Center

Career Start Year 1989

Number of shared co-authors 0

Kun-Liang Guan

University of California San Diego

Career Start Year 1988

Number of shared co-authors 3

Diane L Barber

University of California San Francisco

Career Start Year 1986

Number of shared co-authors 0

Hediye Erdjument-Bromage

Neuroscience Institute, NYU Grossman School of Medicine

Career Start Year 1984

Number of shared co-authors 1

Rohan D Teasdale

The University of Queensland

Career Start Year 1979

Number of shared co-authors 0

Jack E Dixon

University of California

Career Start Year 1972

Number of shared co-authors 3

row(s) 1 - 30 of 30

Christopher Fladd

Hospital for Sick Children

Co-authored papers 10

Julie D Forman-Kay

Hospital for Sick Children

Co-authored papers 7

Bart Kus

Hospital for Sick Children, University of Toronto

Co-authored papers 4

Jason Moffat

University of Toronto

Co-authored papers 3

Michael F Moran

Hospital for Sick Children, University of Toronto

Co-authored papers 3

Sachdev S Sidhu

School of Pharmacy, University of Waterloo

Co-authored papers 3

Lewis E Kay

University of Toronto

Co-authored papers 2

Mike Tyers

Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal

Co-authored papers 2

Mark S Silverberg

Co-authored papers 2

Jiefei Tong

Hospital for Sick Children

Co-authored papers 2

Eldad Zacksenhaus

University of Toronto

Co-authored papers 2

John Parkinson

The Hospital for Sick Children

Co-authored papers 2

Daniel Durocher

The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital

Co-authored papers 2

James D Wasmuth

University of Calgary

Co-authored papers 2

Wei Xu

Princess Margaret Cancer Centre

Co-authored papers 2

Brian Raught

Princess Margaret Cancer Centre, University Health Network

Co-authored papers 2

Ian D Clarke

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children

Co-authored papers 1

Jeffrey L Wrana

Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital

Co-authored papers 1

Nevan J Krogan (CM4AI)

University of California San Francisco

Co-authored papers 1

William C Skarnes

Wellcome Trust Sanger Institute

Co-authored papers 1

Annie Huang

Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children

Co-authored papers 1

Sirano Dhe-Paganon

Dana-Farber Cancer Institute

Co-authored papers 1

Kevin R Brown

College Street, University of Toronto

Co-authored papers 1

Richard W Wozniak

University of Alberta

Co-authored papers 1

Limei Zhou

ICES (formerly known as the Institute for Clinical Evaluative Sciences)

Co-authored papers 1

Michel L Tremblay

Co-authored papers 1

Miso Mitkovski

Co-authored papers 1

Yufeng Tong

University of Windsor

Co-authored papers 1

David W Andrews

Sunnybrook Research Institute, University of Toronto

Co-authored papers 1

Michael Prakesch

Ontario Institute for Cancer Research, University Avenue

Co-authored papers 1

1 - 30

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