Skip to Main Content

Author Details

Namandjé N Bumpus
2004
70
27
PMIDPaper TitleJournal TitlePublished Year
36623884Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems.2023
36305827Interaction of Depot Medroxyprogesterone Acetate and Tenofovir Disoproxil Fumarate/Emtricitabine on Peripheral Blood Mononuclear Cells and Cervical Tissue Susceptibility to HIV Infection and Pharmacokinetics.Journal of acquired immune deficiency syndromes (1999)2023
38019657Tenofovir Douche as HIV Pre-Exposure Prophylaxis for Receptive Anal Intercourse: Safety, Acceptability, Pharmacokinetics, & Pharmacodynamics (DREAM 01).2023
37808667Tenofovir Activation is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice.2023
36627162Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies.2023
36626371Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain.PLoS Genet2023
34529934Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites.Cell Chemical Biology2022
35452678Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.Journal of Biological Chemistry2022
35999181Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid-Based Electrochemical Sensors.Angewandte Chemie - International Edition2022
36433961Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry.Nature Communications2022
34586085Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal.AIDS2022
34561299Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro.Molecular Pharmacology2021
35783008Correction to "Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study".ACS Pharmacol Transl Sci2021
33542124For better drugs, diversify clinical trials.Science2021
33615175Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study.ACS Pharmacol Transl Sci2021
33547874A Mechanistic In Vivo/Ex Vivo Pharmacokinetic-Pharmacodynamic Model of Tenofovir for HIV Prevention.CPT: Pharmacometrics and Systems Pharmacology2021
33191765Metabolism of Long-Acting Rilpivirine After Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076).AIDS Research and Human Retroviruses2021
32960701Pharmacogenomics of Antiretroviral Drug Metabolism and Transport.Annual Review of Pharmacology and Toxicology2021
34678314Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism.J Biol Chem2021
32832868Spatial Distribution Profiles of Emtricitabine, Tenofovir, Efavirenz, and Rilpivirine in Murine Tissues Following Dosing Correlate with Their Safety Profiles in Humans.ACS Pharmacology and Translational Science2020
32065749Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death.Journal of Medicinal Chemistry2020
32059044A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites.PLoS Pathogens2020
32694413Antiretroviral drug concentrations in brain tissue of adult decedents.AIDS2020
32724148Too many senior white academics still resist recognizing racism.Nature2020
31266753Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.Drug Metabolism and Disposition2019
31692269Transgender women on oral HIV pre-exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men.Journal of the International AIDS Society2019
30442673Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1-XBP1.Molecular Pharmacology2019
30137649Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.Clin Pharmacol Ther2019
30628547Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir.Pharmacogenomics2019
31182536Tenofovir Plasma Concentration from Preexposure Prophylaxis at the Time of Potential HIV Exposure: a Population Pharmacokinetic Modeling and Simulation Study Involving Serodiscordant Couples in East Africa.Antimicrobial Agents and Chemotherapy2019
31170851Biotransformation and bioactivation reactions - 2018 literature highlights.Drug Metabolism Reviews2019
29455571Genetic Variation of the Kinases That Phosphorylate Tenofovir and Emtricitabine in Peripheral Blood Mononuclear Cells.AIDS Res Hum Retroviruses2018
30037813MALDI Mass Spectrometry Imaging Reveals Heterogeneous Distribution of Tenofovir and Tenofovir Diphosphate in Colorectal Tissue of Subjects Receiving a Tenofovir-Containing Enema.Journal of Pharmacology and Experimental Therapeutics2018
29090394Utility of Different Adherence Measures for PrEP: Patterns and Incremental Value.AIDS and Behavior2018
29430850Probing Ligand Structure-Activity Relationships in Pregnaneâ¿¿X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation.ChemMedChem2018
29641561Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067.PLoS ONE2018
27775344Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.Biochemistry2016
26801248Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.Clinical Cancer Research2016
26414912Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066).AIDS Research and Human Retroviruses2016
27860311Single Heteroatom Substitutions in the Efavirenz Oxazinone Ring Impact Metabolism by CYP2B6.ChemMedChem2016
26501112Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.eBioMedicine2015
25838403Response to "clinical relevance of CYP3A5 genotype on maraviroc exposures".Drug Metabolism and Disposition2015
26614966Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.Lancet HIV2015
24594750A targeted proteomics approach for profiling murine cytochrome P450 expression.Journal of Pharmacology and Experimental Therapeutics2014
25309681Structure-Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz.ACS Medicinal Chemistry Letters2014
25350130Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study.PLoS ONE2014
25350119A multi-compartment single and multiple dose pharmacokinetic comparison of rectally applied tenofovir 1% gel and oral tenofovir disoproxil fumarate.PLoS ONE2014
24105977Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice.Molecular Pharmacology2014
24336828A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy.Clin Infect Dis2014
24983818Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.Journal of the American Chemical Society2014
  • 1 - 50 of 70

Recommended Authors

Collaborators

Co-authored papers 5
The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
Co-authored papers 3
University of California san francisco
Co-authored papers 3
University of California San Francisco
Co-authored papers 3
university of california los angeles Center for Clinical AIDS Research & Education
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Frederick National Laboratory
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
University of California, university of california san diego
Co-authored papers 1
Co-authored papers 1
University of Manitoba
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Johns Hopkins School of Medicine
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
University of California
Co-authored papers 1
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1