Author details

Full Name

David M Sabatini

Affiliation

Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology

ORCID

Career Start Year

1990

Papers

264

H Index

137

Expertise

CM4AI Collaborator

Nevan J Krogan (CM4AI)

PMID	Paper Title	Journal Title	Published Year
37292894	An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway.	bioRxiv	2023
34706266	GCN2 adapts protein synthesis to scavenging-dependent growth.	Cell Syst	2022
35771919	Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.	Science	2022
35831510	Structure of the nutrient-sensing hub GATOR2.	Nature	2022
35859173	Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.	Nature	2022
36409067	Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction.	Elife	2022
36104569	Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.	Nature	2022
36100671	Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.	Nature	2022
36131016	CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.	Nature	2022
35017686	Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity.	Nature	2022
34135321	Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.	Nat Commun	2021
33651980	CRISPR screens in physiologic medium reveal conditionally essential genes in human cells.	Cell Metab	2021
33483422	Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.	Proc Natl Acad Sci U S A	2021
33658354	<i>APOE4</i> disrupts intracellular lipid homeostasis in human iPSC-derived glia.	Sci Transl Med	2021
34855504	Fumarate is a terminal electron acceptor in the mammalian electron transport chain.	Science	2021
34607910	mTOR-Activating Mutations in <i>RRAGD</i> Are Causative for Kidney Tubulopathy and Cardiomyopathy.	J Am Soc Nephrol	2021
32375022	A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.	Cell Metab	2020
31937935	mTOR at the nexus of nutrition, growth, ageing and disease.	Nat Rev Mol Cell Biol	2020
31996837	Author Correction: A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.	Nat Med	2020
31959991	A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.	Nat Med	2020
32005970	Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease.	Nat Rev Mol Cell Biol	2020
31649036	Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.	J Exp Med	2020
33087354	MCART1/SLC25A51 is required for mitochondrial NAD transport.	Sci Adv	2020
33208952	MFSD12 mediates the import of cysteine into melanosomes and lysosomes.	Nature	2020
33148642	Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.	Sci Adv	2020
32719541	Dihydroxyacetone phosphate signals glucose availability to mTORC1.	Nat Metab	2020
32571778	Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.	Cancer Discov	2020
32704543	Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition.	Sci Adv	2020
32694612	Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells.	Sci Rep	2020
32214253	Dietary modifications for enhanced cancer therapy.	Nature	2020
32111721	Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.	J Biol Chem	2020
32434850	<i>ATRAID</i> regulates the action of nitrogen-containing bisphosphonates on bone.	Sci Transl Med	2020
32405003	Author Correction: Tumours with PI3K activation are resistant to dietary restriction.	Nature	2020
32268298	Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.	Aging (Albany NY)	2020
30541894	MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.	Proc Natl Acad Sci U S A	2019
31704029	Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.	Cell	2019
31722960	Nutrient regulation of mTORC1 at a glance.	J Cell Sci	2019
32694817	The next decade of metabolism.	Nat Metab	2019
29969188	DEPTOR modulates activation responses in CD4<sup>+</sup> T cells and enhances immunoregulation following transplantation.	Am J Transplant	2019
31292548	Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.	Nature	2019
31601764	Architecture of human Rag GTPase heterodimers and their complex with mTORC1.	Science	2019
31601708	Structural basis for the docking of mTORC1 on the lysosomal surface.	Science	2019
31314152	C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly.	FEBS Open Bio	2019
31019072	Genome-wide CRISPR screen for Zika virus resistance in human neural cells.	Proc Natl Acad Sci U S A	2019
31072927	Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.	Proc Natl Acad Sci U S A	2019
30760928	Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.	Nature	2019
30651352	Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.	J Biol Chem	2019
30542996	Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines.	Methods Mol Biol	2019
29274432	A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.	Neurobiol Dis	2018
29995852	Histidine catabolism is a major determinant of methotrexate sensitivity.	Nature	2018

1 - 50 of 264

Aurelien Dugourd

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University

Career Start Year 2016

Number of shared co-authors 2

Alexandre Rosa Campos

Sanford Burnham Prebys Medical Discovery Institute

Career Start Year 2015

Number of shared co-authors 1

Gian Luca Negri

British Columbia Cancer Research Institute

Career Start Year 2013

Number of shared co-authors 2

David Papadopoli

McGill University

Career Start Year 2013

Number of shared co-authors 1

Min Gao

College of Horticulture, China Agricultural University

Career Start Year 2012

Number of shared co-authors 1

Carolyn Jones

University of Cambridge

Career Start Year 2012

Number of shared co-authors 1

Florent Dingli

Institut Curie, PSL Research University

Career Start Year 2011

Number of shared co-authors 0

Rebecca S Levin

Howard Hughes Medical Institute, University of California San Francisco

Career Start Year 2010

Number of shared co-authors 2

Margret H Ogmundsdottir

Biomedical Center, University of Iceland

Career Start Year 2007

Number of shared co-authors 1

Gabriel Leprivier

Institute of Neuropathology, Heinrich-Heine University Dusseldorf

Career Start Year 2006

Number of shared co-authors 2

Jonathan M Dreyfuss

Joslin Diabetes Center, Harvard Medical School

Career Start Year 2005

Number of shared co-authors 5

Mark Larance

The University of Sydney

Career Start Year 2005

Number of shared co-authors 2

Joseph Tcherkezian

Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal

Career Start Year 2004

Number of shared co-authors 2

Nicholas A Graham

University of Southern California

Career Start Year 2004

Number of shared co-authors 1

Ganna Panasyuk

Institut Necker-Enfants Malades (INEM)

Career Start Year 2002

Number of shared co-authors 3

Barak Rotblat

Ben-Gurion University of the Negev

Career Start Year 2002

Number of shared co-authors 8

Baggavalli P Somesh

Connexios Life Sciences Pvt Ltd

Career Start Year 2000

Number of shared co-authors 3

Alykhan F Shamji

Center for the Science of Therapeutics, Broad Institute

Career Start Year 1999

Number of shared co-authors 24

Rachel Toth

University of Dundee

Career Start Year 1999

Number of shared co-authors 5

Philippe P Roux

IRIC - University of Montreal

Career Start Year 1998

Number of shared co-authors 5

Rasmus Hartmann-Petersen

University of Copenhagen

Career Start Year 1998

Number of shared co-authors 1

Michael C Bassik

Stanford University Medical Center

Career Start Year 1997

Number of shared co-authors 14

Gregory M Ku

Diabetes Center, University of California san francisco

Career Start Year 1996

Number of shared co-authors 2

Davide Ruggero

University of California San Francisco

Career Start Year 1996

Number of shared co-authors 6

Brian Raught

Princess Margaret Cancer Centre, University Health Network

Career Start Year 1994

Number of shared co-authors 9

Michael A White

University of Georgia

Career Start Year 1994

Number of shared co-authors 10

Dario R Alessi

University of Dundee

Career Start Year 1992

Number of shared co-authors 5

John Easton

St Jude Children's Research Hospital

Career Start Year 1991

Number of shared co-authors 3

Roland Nilsson

Karolinska Institutet

Career Start Year 1980

Number of shared co-authors 3

Chi V Dang

Johns Hopkins University School of Medicine

Career Start Year 1978

Number of shared co-authors 9

row(s) 1 - 30 of 30

Timothy C Wang

Division of Gastroenterology and Irvine Cancer Research Center, Columbia University

Co-authored papers 20

Nathanael S Gray

Harvard Medical School

Co-authored papers 18

Mathieu Laplante

Centre de recherche sur le cancer de l'Universite Laval, Universite Laval

Co-authored papers 14

Eric S Lander

Vanderbilt-Ingram Cancer Center, Vanderbilt University

Co-authored papers 13

Anne E Carpenter

Broad Institute of MIT and Harvard

Co-authored papers 13

Solomon H Snyder

Co-authored papers 12

David E Root

Broad Institute of Harvard and MIT

Co-authored papers 12

William C Hahn

Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute

Co-authored papers 11

Siraj M Ali

Foundation Medicine

Co-authored papers 9

Jason Moffat

University of Toronto

Co-authored papers 6

Kris C Wood

Duke University

Co-authored papers 5

Paul Tempst

Memorial Sloan Kettering Cancer Center

Co-authored papers 5

Hediye Erdjument-Bromage

Neuroscience Institute, NYU Grossman School of Medicine

Co-authored papers 5

Jan E Carette

Stanford University School of Medicine

Co-authored papers 5

Nir Hacohen

Broad Institute of MIT and Harvard

Co-authored papers 5

J. Wade Harper

Harvard Medical School

Co-authored papers 5

Levi A Garraway

Broad Institute of Harvard and MIT

Co-authored papers 4

Steven P Gygi

Harvard Medical School

Co-authored papers 4

Clary B Clish

Broad Institute of MIT and Harvard

Co-authored papers 4

Norbert Perrimon

Co-authored papers 4

Kenneth D Westover

University of Texas Southwestern Medical Center

Co-authored papers 4

Matthew Meyerson

Broad Institute

Co-authored papers 3

Barbara A Weir

Janssen Research and Development LLC

Co-authored papers 3

Jesse S Boehm

Broad Institute of Harvard and MIT

Co-authored papers 3

Roxanne K Barrow

Co-authored papers 3

Choah Kim

Co-authored papers 3

Steven A Carr

Broad Institute of MIT and Harvard

Co-authored papers 3

Polina Golland

Massachusetts Institute of Technology

Co-authored papers 3

Tyler Jacks

Co-authored papers 3

Serena J Silver

Co-authored papers 3

1 - 30

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