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Author Details

Richard N Armstrong
The Hospital for Sick Children
1978
123
43
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35643866Germline PTPN13 mutations in patients with bone marrow failure and acute lymphoblastic leukemia.Leukemia2022
32309216CRISPR/Cas9-Mediated Foxp1 Silencing Restores Immune Surveillance in an Immunocompetent A20 Lymphoma Model.Front Oncol2020
30787430Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes.Leukemia2019
28986033Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches.Adv Biol Regul2018
29930011Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.Blood2018
28862641The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.J Clin Invest2017
28436936The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.J Clin Invest2017
28809482Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen-Deuterium Exchange.Biochemistry2017
28558199Global Kinetic Mechanism of Microsomal Glutathione Transferase 1 and Insights into Dynamic Enzyme Activation.Biochemistry2017
26968532RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature.Blood2016
27684486Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E2 Synthase 1 and Ser127 Is Not.PLoS One2016
27211273Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes.Leukemia2016
25517407New frontiers in kinases.Biochemistry2015
26177047Staphylococcus aureus CstB Is a Novel Multidomain Persulfide Dioxygenase-Sulfurtransferase Involved in Hydrogen Sulfide Detoxification.Biochemistry2015
24447055Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus.Biochemistry2014
24802635Prediction of substrates for glutathione transferases by covalent docking.J Chem Inf Model2014
24756107Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.PLoS Biol2014
24660987Call for papers! A special thematic compilation/special issue crossover with ACS Chemical Biology, ACS Medicinal Chemistry Letters, and the Journal of Medicinal Chemistry focused on new frontiers in kinases.Biochemistry2014
22936014Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.Leukemia2013
24004181Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus.Biochemistry2013
22329346Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution.Biochemistry2012
23030527Synthesis of bacillithiol and the catalytic selectivity of FosB-type fosfomycin resistance proteins.Org Lett2012
22517724Differential TERT promoter methylation and response to 5-aza-2'-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death.Genes Chromosomes Cancer2012
22359303Microarray for epigenetic changes: gene expression arrays.Methods Mol Biol2012
22359301Screening for miRNA expression changes using quantitative PCR (Q-PCR).Methods Mol Biol2012
22359300Detection and analysis of DNA methylation by pyrosequencing.Methods Mol Biol2012
22356188Observation of two modes of inhibition of human microsomal prostaglandin E synthase 1 by the cyclopentenone 15-deoxy-ο(12,14)-prostaglandin J(2).Biochemistry2012
21222452Structure and function of YghU, a nu-class glutathione transferase related to YfcG from Escherichia coli.Biochemistry2011
21999478The Enzyme Function Initiative.Biochemistry2011
21805999Location of inhibitor binding sites in the human inducible prostaglandin E synthase, MPGES1.Biochemistry2011
20956966A large-scale protein-function database.Nat Chem Biol2010
19196010Evolution of the antibiotic resistance protein, FosA, is linked to a catalytically promiscuous progenitor.Biochemistry2009
19416719Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione.Arch Biochem Biophys2009
19537707Analysis of the structure and function of YfcG from Escherichia coli reveals an efficient and unique disulfide bond reductase.Biochemistry2009
18167079New initiatives pertaining to biochemistry in 2008.Biochemistry2008
18703268Characterization of the binding of 8-anilinonaphthalene sulfonate to rat class Mu GST M1-1.Biophys Chem2008
18052347Structural elements involved in proton translocation by cytochrome c oxidase as revealed by backbone amide hydrogen-deuterium exchange of the E286H mutant.Biochemistry2008
175087262-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida.Biochemistry2007
17537395A model for glutathione binding and activation in the fosfomycin resistance protein, FosA.Arch Biochem Biophys2007
17567049Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes.Biochemistry2007
17297922Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1.Biochemistry2007
16475815Double mutation at the subunit interface of glutathione transferase rGSTM1-1 results in a stable, folded monomer.Biochemistry2006
17023543Mapping protein dynamics in catalytic intermediates of the redox-driven proton pump cytochrome c oxidase.Proc Natl Acad Sci U S A2006
15581564Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry.Arch Biochem Biophys2005
16399398Fosfomycin resistance proteins: a nexus of glutathione transferases and epoxide hydrolases in a metalloenzyme superfamily.Methods Enzymol2005
15941264Enzyme control of small-molecule coordination in FosA as revealed by 31P pulsed ENDOR and ESE-EPR.J Am Chem Soc2005
16060669Influence of the dimer interface on glutathione transferase structure and dynamics revealed by amide H/D exchange mass spectrometry.Biochemistry2005
15075406Structure of fosfomycin resistance protein FosA from transposon Tn2921.Protein Sci2004
15236595Kinetic characterization of thiolate anion formation and chemical catalysis of activated microsomal glutathione transferase 1.Biochemistry2004
15504029Phosphonoformate: a minimal transition state analogue inhibitor of the fosfomycin resistance protein, FosA.Biochemistry2004
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Collaborators

The Joint Center for Structural Genomics, Stanford University
Co-authored papers 6
University of Wisconsin
Co-authored papers 3
University of Pavia & S. Matteo Hospital
Co-authored papers 3
University of California san francisco
Co-authored papers 3
University of California San Francisco
Co-authored papers 2
Albert Einstein College of Medicine
Co-authored papers 2
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Kyoto University
Co-authored papers 2
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
University of California san francisco
Co-authored papers 2
University of Montreal
Co-authored papers 1
University of Illinois at Urbana-Champaign
Co-authored papers 1
University of Utah
Co-authored papers 1
College of Biotechnology and Bioengineering, Zhejiang University of Technology
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
Albert Einstein College of Medicine
Co-authored papers 1
Albert Einstein College of Medicine
Co-authored papers 1
Universite de Montreal
Co-authored papers 1
Co-authored papers 1
Medical College of Wisconsin
Co-authored papers 1
Universite de Montreal
Co-authored papers 1
University of Illinois
Co-authored papers 1
Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University Jena
Co-authored papers 1
The Weizmann Institute of Science
Co-authored papers 1
University of Geneva
Co-authored papers 1
IBM Corporation
Co-authored papers 1
Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL)
Co-authored papers 1
Co-authored papers 1
Boston University
Co-authored papers 1
Gwangju Institute of Science and Technology
Co-authored papers 1