Author details

Full Name

Philip L S M Gordts

Affiliation

ORCID

Career Start Year

2009

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37492105	Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins.	Cell Genom	2023
37668303	Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development.		2023
36931394	Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.	J Biol Chem	2023
35354934	Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate.	Nat Chem Biol	2022
35653195	Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering.	JCI insight	2022
36162056	Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity.	Diabetes	2022
35574759	Biologically Derived Neoproteoglycans for Profiling Protein-Glycosaminoglycan Interactions.	ACS Chemical Biology	2022
35750212	Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation.	Journal of Biological Chemistry	2022
34587757	Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated With Human-Like Neu5Gc Loss-Brief Report.	Arteriosclerosis, Thrombosis, and Vascular Biology	2021
33846619	Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate.	Nat Chem Biol	2021
33791697	The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection.	bioRxiv	2021
31111151	Statin therapy increases lipoprotein(a) levels.	Eur Heart J	2020
32144003	Corrigendum to "The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis" [Matrix Biol. 71-72 (2018) 262-282].	Matrix Biology	2020
31964837	Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via loss.	Proceedings of the National Academy of Sciences of the United States of America	2020
31893480	Statins and increases in Lp(a): an inconvenient truth that needs attention.	Eur Heart J	2020
32169857	Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.	Journal of Biological Chemistry	2020
32277030	ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.	Proc Natl Acad Sci U S A	2020
32091093	Corrigendum to: Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants.	Glycobiology	2020
32709762	Correction: Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.	Journal of Biological Chemistry	2020
32699853	SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.	bioRxiv	2020
33119548	microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production.	JCI insight	2020
32508807	Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation.	Frontiers in Immunology	2020
31315930	Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.	Journal of Biological Chemistry	2019
32694849	Hyaluronan as a potential thermogenic rheostat.	Nature Metabolism	2019
31094413	Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants.	Glycobiology	2019
31092690	ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance.	J Lipid Res	2019
30904610	PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles.		2019
31390883	ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors.	Arteriosclerosis, Thrombosis, and Vascular Biology	2019
31004319	LRP1 Has a Predominant Role in Production over Clearance of AÎ² in a Mouse Model of Alzheimer's Disease.	Molecular Neurobiology	2019
30668905	Efficient Synthesis of Heparinoid Bioconjugates for Tailoring FGF2 Activity at the Stem Cell-Matrix Interface.	Bioconjugate Chemistry	2019
31332008	Human species-specific loss of CMP--acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms.	Proceedings of the National Academy of Sciences of the United States of America	2019
29803939	The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis.	Matrix Biology	2018
30354205	Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants.	Arteriosclerosis, Thrombosis, and Vascular Biology	2018
30100244	The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.	Molecular Metabolism	2018
29559522	AIBP protects against metabolic abnormalities and atherosclerosis.	Journal of Lipid Research	2018
29547399	Apolipoprotein C-III in triglyceride-rich lipoprotein metabolism.	Current Opinion in Lipidology	2018
29111225	ANGPTL3 targeting: The power of versatile lipid-lowering.	Atherosclerosis	2018
29237845	Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms.	Journal of Virology	2018
28062489	Lipoprotein(a) Mass Levels Increase Significantly According to Genotype: An Analysis of 431â¿¿239 Patients.	Arteriosclerosis, Thrombosis, and Vascular Biology	2017
28958576	Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain.	Molecular Therapy	2017
28360338	Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgR<sub>KT</sub> to the List.	Circ Res	2017
26708286	Dietary nitrate struggles in atherosclerosis.	Atherosclerosis	2016
27400128	ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.	Journal of Clinical Investigation	2016
26986213	Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I.	PLoS ONE	2016
28133533	Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions.	Chemical Science	2015
25848753	Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.	Nat Genet	2015
25754609	Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.	Nature Communications	2015
25573804	Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-Î².	Cytokine	2015
25568062	Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans.	Journal of Lipid Research	2015
25440058	Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling.	Cell Metab	2014