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Author Details

Paul J Fletcher
Campbell Family Mental Health Research Institute, University of Toronto
1984
192
54
PMIDPaper TitleJournal TitlePublished Year
37059187Effects of 5-HT<sub>2C</sub> receptor stimulation in male mice on behaviour and Fos expression: Feeding, reward and impulsivity.Behav Brain Res2023
36271094Behavioural phenotypes of intrinsic motivation in schizophrenia determined by cluster analysis of objectively quantified real-world performance.Schizophrenia (Heidelb)2022
35644487Effects of pimavanserin and lorcaserin on alcohol self-administration and reinstatement in male and female rats.Neuropharmacology2022
33039433Prenatal disruption of D1R-SynGAP complex causes cognitive deficits in adulthood.Prog Neuropsychopharmacol Biol Psychiatry2021
33928736The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking.Addict Biol2021
31629010Lorcaserin: A review of its preclinical and clinical pharmacology and therapeutic potential.Pharmacol Ther2020
31905371Effects of exposure to chronic uncertainty and a sensitizing regimen of amphetamine injections on locomotion, decision-making, and dopamine receptors in rats.Neuropsychopharmacology2020
31897573Clozapine reliably increases the motivation for food: parsing the role of the 5-HT<sub>2c</sub> and H<sub>1</sub> receptors.Psychopharmacology (Berl)2020
32035145Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus.Neuropharmacology2020
32840668The pharmacological stressor yohimbine, but not U50,488, increases responding for conditioned reinforcers paired with ethanol or sucrose.Psychopharmacology (Berl)2020
32494974Serotonin transporter protein in autopsied brain of chronic users of cocaine.Psychopharmacology (Berl)2020
29575323Clozapine reduces nicotine self-administration, blunts reinstatement of nicotine-seeking but increases responding for food.Addict Biol2019
31387938Disruption of SynGAP-dopamine D1 receptor complexes alters actin and microtubule dynamics and impairs GABAergic interneuron migration.Sci Signal2019
30550794Nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex.Neuropharmacology2019
30420603Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition.Neuropsychopharmacology2019
30694374Adolescent exposure to ο9-tetrahydrocannabinol delays acquisition of paired-associates learning in adulthood.Psychopharmacology (Berl)2019
30414973Kappa opioid receptors mediate yohimbine-induced increases in impulsivity in the 5-choice serial reaction time task.Behav Brain Res2019
29498158Preclinical evidence for combining the 5-HT<sub>2C</sub> receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence.Addict Biol2019
28954705Objective assessment of exploratory behaviour in schizophrenia using wireless motion capture.Schizophr Res2018
29980136Objective investigation of activity preference in schizophrenia: A pilot study.Psychiatry Res2018
28318841Acquisition of nicotine self-administration in amphetamine and phencyclidine models of schizophrenia: A role for stress?Schizophr Res2018
29354053Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and οFosB.Front Pharmacol2018
29505786Deep brain stimulation and fluoxetine exert different long-term changes in the serotonergic system.Neuropharmacology2018
29174865Deep brain stimulation induces antidepressant-like effects in serotonin transporter knockout mice.Brain Stimul2018
27565433Lipoic acid and haloperidol-induced vacuous chewing movements: Implications for prophylactic antioxidant use in tardive dyskinesia.Prog Neuropsychopharmacol Biol Psychiatry2017
28485732Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse.Transl Psychiatry2017
28338324Studies To Examine Potential Tolerability Differences between the 5-HT<sub>2C</sub> Receptor Selective Agonists Lorcaserin and CP-809101.ACS Chem Neurosci2017
28097374Effects of 5-HT<sub>1A</sub>, 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate.Psychopharmacology (Berl)2017
29072522Role of impulsivity and reward in the anti-obesity actions of 5-HT<sub>2C</sub> receptor agonists.J Psychopharmacol2017
28832319Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder.J Psychiatry Neurosci2017
28720903Pharmacological Modulation of 5-HT<sub>2C</sub> Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice.Neuropsychopharmacology2017
26690588Responding for a conditioned reinforcer or unconditioned sensory reinforcer in mice: interactions with environmental enrichment, social isolation, and monoamine reuptake inhibitors.Psychopharmacology (Berl)2016
26427596The 5-HT(2C) receptor agonist lorcaserin reduces cocaine self-administration, reinstatement of cocaine-seeking and cocaine induced locomotor activity.Neuropharmacology2016
27241709Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists.Psychopharmacology (Berl)2016
27125304Decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter: Role of the 5-HT2C Receptor.Neuropsychopharmacology2016
27480020Disruption of a dopamine receptor complex amplifies the actions of cocaine.Eur Neuropsychopharmacol2016
27329152Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice.Behav Brain Res2016
27251130Atypical antipsychotics and effects on feeding: from mice to men.Psychopharmacology (Berl)2016
26976325The adrenergic α2 antagonist atipamezole alters the behavioural effects of pramipexole and increases pramipexole concentration in blood plasma.Life Sci2016
26781518Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens Dopamine Release.Neuropsychopharmacology2016
25283483Low dose pramipexole causes D3 receptor-independent reduction of locomotion and responding for a conditioned reinforcer.Neuropharmacology2015
25870913Therapeutic Potential of 5-HT2C Receptor Agonists for Addictive Disorders.ACS Chem Neurosci2015
25692009Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity.Pharmacol Res Perspect2015
25661529Behavioral effects of food-derived opioid-like peptides in rodents: Implications for schizophrenia?Pharmacol Biochem Behav2015
25781911The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine.ACS Chem Neurosci2015
25567425Antipsychotics and amotivation.Neuropsychopharmacology2015
24001874Effects of intracerebroventricular (ICV) olanzapine on insulin sensitivity and secretion in vivo: an animal model.Eur Neuropsychopharmacol2014
25433637A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects.Neuron2014
25230208Examination of the effects of varenicline, bupropion, lorcaserin, or naltrexone on responding for conditioned reinforcement in nicotine-exposed rats.Behav Pharmacol2014
25158104Responding for a conditioned reinforcer, and its enhancement by nicotine, is blocked by dopamine receptor antagonists and a 5-HT(2C) receptor agonist but not by a 5-HT(2A) receptor antagonist.Pharmacol Biochem Behav2014
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Collaborators

University of Toronto
Co-authored papers 21
Neurochemical Research Unit, University of Alberta
Co-authored papers 5
Institute of Neurosciences and Medicine
Co-authored papers 5
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 5
Campbell Family Mental Health Research Institute
Co-authored papers 4
Campbell Family Mental Health Research Institute and Research Imaging Center
Co-authored papers 4
University of Guelph
Co-authored papers 3
Campbell Family Mental Health Research Institute
Co-authored papers 3
Institute of Medical Science, University of Toronto
Co-authored papers 2
Co-authored papers 1
The Hospital for Sick Children, University of Toronto
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University Avenue R988
Co-authored papers 1
University of California los angeles
Co-authored papers 1
McGill University
Co-authored papers 1
The Hospital for Sick Children, University of Oxford, University of Toronto
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 1