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Author Details

Alejandro Losada
Hospital Infantil Universitario "La Paz"
1999
13
12
Kirsten Obernier (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35231500Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis.Antiviral Res2022
33495306Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.Science2021
31812675Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells.Biochem Pharmacol2020
29348621Dynamic cellular maps of molecular species: Application to drug-target interactions.Sci Rep2018
30420615Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival.Br J Cancer2018
27713531Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin.Sci Rep2016
21718029Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment.J Nat Prod2011
19513942The mechanism of action of plitidepsin.Curr Opin Investig Drugs2009
15365569Establishment and characterisation of a human carcinoma cell line with acquired resistance to Aplidin.Br J Cancer2004
12414812Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.J Biol Chem2003
12386816Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta.Oncogene2002
10830305Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids.Endocrinology2000
10370019Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1.Pediatr Surg Int1999
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Collaborators

Pablo Avil??s
Departamento de Toxicologia y Farmacologia Preclinica
Co-authored papers 3
Jose M Fern??ndez-Sousa
Co-authored papers 2
Ajda Rojc
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Bonaventura Clotet
IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Thomas P Zwaka
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Carles Mart??nez-Romero
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Jacqueline M Fabius
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Kris M White
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 1
Kevan M Shokat
University of California San Francisco
Co-authored papers 1
Thomas Kehrer
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Marco Vignuzzi
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 1
Marion Dejosez
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Soner Yildiz
University of Geneva
Co-authored papers 1
Jyoti Batra
J. David Gladstone Institutes
Co-authored papers 1
Melissa B Uccellini
Icahn School of Medicine at Mount Sinaigrid.59734.3c
Co-authored papers 1
Roger Paredes
Hospital Germans Trias i Pujol
Co-authored papers 1
Michael Schotsaert
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Jordi Rodon
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Nuria Izquierdo-Useros
IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol
Co-authored papers 1
Kirsten Obernier (CM4AI)
University of California San Francisco
Co-authored papers 1
Raveen Rathnasinghe
Icahn School of Medicine at Mount Sinai New York
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J??lia Vergara-Alert
Campus de la Universitat Autonoma de Barcelona (UAB)
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Lynda Coughlan
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Lisa Miorin
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Instituto de Investigaciones Biomedicas "Alberto Sols"
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Release 1.2