Author details

Full Name

Christian GrÃ¼tter

Affiliation

ORCID

Career Start Year

1994

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
26275028	Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.	J Med Chem	2015
24754677	Identification of type II and III DDR2 inhibitors.	Journal of Medicinal Chemistry	2014
23247173	Natural-product-derived fragments for fragment-based ligand discovery.	Nature Chemistry	2013
23911552	Structural characterization of the RLCK family member BSK8: a pseudokinase with an unprecedented architecture.	Journal of Molecular Biology	2013
23773153	Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.	J Med Chem	2013
23270382	Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.	Journal of Medicinal Chemistry	2013
23249378	Strategies for the selective regulation of kinases with allosteric modulators: exploiting exclusive structural features.	ACS Chemical Biology	2013
23611635	Selective detection of allosteric phosphatase inhibitors.	Journal of the American Chemical Society	2013
22154891	Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38Î±.	European Journal of Medicinal Chemistry	2012
22545924	Targeting GSK3 from Ustilago maydis: type-II kinase inhibitors as potential antifungals.	ACS Chemical Biology	2012
22676210	Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.	Journal of Medicinal Chemistry	2012
22768308	Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38Î± kinase.	PLoS ONE	2012
22941188	Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.	Nat Genet	2012
21948233	ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.	Clin Cancer Res	2011
21130659	Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.	Bioorg Med Chem	2011
21671622	Identification of Ustilago maydis Aurora kinase as a novel antifungal target.	ACS Chemical Biology	2011
22198732	Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.	Nature Chemical Biology	2011
20201574	Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.	Journal of the American Chemical Society	2010
21080395	Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance.	ChemBioChem	2010
19928858	Displacement assay for the detection of stabilizers of inactive kinase conformations.	Journal of Medicinal Chemistry	2010
19950957	High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha.	Journal of the American Chemical Society	2009
19741300	Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components.	Journal of Clinical Investigation	2009
19396179	A new screening assay for allosteric inhibitors of cSrc.	Nature Chemical Biology	2009
19729025	The crystal structure of human pyrin b30.2 domain: implications for mutations associated with familial Mediterranean fever.	Journal of Molecular Biology	2009
19572644	Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.	Journal of the American Chemical Society	2009
19462975	Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.	Journal of Medicinal Chemistry	2009
19153241	An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding.	Journal of Virology	2009
18316192	Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.	Bioorganic and Medicinal Chemistry	2008
19073914	A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions.	Proceedings of the National Academy of Sciences of the United States of America	2008
17431422	The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.	Cell Death and Differentiation	2007
16447150	A biomimetic chromanol cyclization leading to alpha-tocopherol.	Angewandte Chemie - International Edition	2006
16364311	Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.	FEBS Letters	2006
9976474	Surface melting of gallium single crystals.	Physical Review B-Condensed Matter	1994