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Author Details

Pedro E Cruz
College of Medicine, University of Florida
1994
102
36
PMIDPaper TitleJournal TitlePublished Year
36535953Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance.NPJ Parkinsons Dis2022
33128896Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes.Mol Ther2021
33741985Il-10 signaling reduces survival in mouse models of synucleinopathy.NPJ Parkinsons Dis2021
33614654Consistent Long-Term Therapeutic Efficacy of Human Umbilical Cord Matrix-Derived Mesenchymal Stromal Cells After Myocardial Infarction Despite Individual Differences and Transient Engraftment.Front Cell Dev Biol2021
33496840Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.Acta Neuropathol2021
33957936Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.Mol Neurodegener2021
32122372Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.Mol Neurodegener2020
31903524Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy.Mol Neurobiol2020
33069251Aÿ40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aÿ42 toxicity in Drosophila.Alzheimers Res Ther2020
30770411rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies.J Exp Med2019
31685865Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus.Sci Rep2019
31455873Downregulation of the human peripheral myelin protein 22 gene by miR-29a in cellular models of Charcot-Marie-Tooth disease.Gene Ther2019
30711010Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.Alzheimers Res Ther2019
31042463APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.Cell Rep2019
30804924The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis.Front Immunol2019
27864463Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage.J Cereb Blood Flow Metab2018
30158114TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.J Exp Med2018
30341064High-affinity interactions and signal transduction between Aβ oligomers and TREM2.EMBO Mol Med2018
29208777Short Aβ peptides attenuate Aβ42 toxicity in vivo.J Exp Med2018
28040463Umbilical cord tissue-derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing.Cytotherapy2017
27909741The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells.Arch Toxicol2017
27590069Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro.Arch Toxicol2017
27308302Microglia-specific targeting by novel capsid-modified AAV6 vectors.Mol Ther Methods Clin Dev2016
27680210Therapeutic angiogenesis induced by human umbilical cord tissue-derived mesenchymal stromal cells in a murine model of hindlimb ischemia.Stem Cell Res Ther2016
24480602The Human Umbilical Cord Tissue-Derived MSC Population UCX(®) Promotes Early Motogenic Effects on Keratinocytes and Fibroblasts and G-CSF-Mediated Mobilization of BM-MSCs When Transplanted In Vivo.Cell Transplant2015
26658861Re-Opening the Critical Window for Estrogen Therapy.J Neurosci2015
26156074IFN-γ promotes Ͽ phosphorylation without affecting mature tangles.FASEB J2015
26152284Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.Mol Neurodegener2015
26064137What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?Stem Cells Int2015
25904780A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo.J Neurosci2015
25943527Human amniocyte-derived cells are a promising cell host for adenoviral vector production under serum-free conditions.Biotechnol J2015
25956381Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing.Stem Cell Res Ther2015
25619653IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.Neuron2015
25228069Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.Mol Ther2015
24411922Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms.Stem Cell Res Ther2014
25350374Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.PLoS One2014
25075157Effects of umbilical cord tissue mesenchymal stem cells (UCX®) on rat sciatic nerve regeneration after neurotmesis injuries.J Stem Cells Regen Med2014
24620716Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.Biochemistry2014
24352661γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.J Biol Chem2014
24438697Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.Stem Cell Res Ther2014
23324136The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis.J Transl Med2013
23825679Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain.PLoS One2013
23774650Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.Brain Res2013
23714769Conformational templating of α-synuclein aggregates in neuronal-glial cultures.Mol Neurodegener2013
22526458Regulation of ENaC biogenesis by the stress response protein SERP1.Pflugers Arch2012
23285814Thymus mastichina: chemical constituents and their anti-cancer activity.Nat Prod Commun2012
22934827Downstream processing of lentiviral vectors: releasing bottlenecks.Hum Gene Ther Methods2012
20693405N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance.Am J Respir Cell Mol Biol2011
21590397Manufacturing of retroviruses.Methods Mol Biol2011
21420496Cellular fusion for gene delivery to SCA1 affected Purkinje neurons.Mol Cell Neurosci2011
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Collaborators

Emory Center for Neurodegenerative Disease
Co-authored papers 29
Co-authored papers 15
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 14
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 13
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 13
Emory University School of Medicine
Co-authored papers 12
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 5
College of Medicine, University of Florida
Co-authored papers 4
College of Medicine, University of Florida
Co-authored papers 4
Co-authored papers 4
Institute for Systems Biology
Co-authored papers 3
College of Medicine, Penn State College of Medicine
Co-authored papers 3
Mayo Clinic Jacksonville
Co-authored papers 3
Johns Hopkins University School of Medicine
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Institute for Systems Biology
Co-authored papers 3
Mayo Clinic
Co-authored papers 2
University of Florida
Co-authored papers 2
National Cancer Institute (NCI)
Co-authored papers 2
Gannan Medical University
Co-authored papers 2
Mayo Clinic
Co-authored papers 2
Mayo Clinic
Co-authored papers 2
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 2
Mayo Clinic
Co-authored papers 1
Mayo Clinic College of Medicine
Co-authored papers 1
University of Florida
Co-authored papers 1
College of Medicine, University of Florida
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1