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Author Details

Steven G Younkin
Mayo Clinic
1971
243
96
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37461624Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies <i>LRRC4C, LHX5-AS1</i> and nominates ancestry-specific loci <i>PTPRK</i> , <i>GRB14</i> , and <i>KIAA0825</i> as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.medRxiv2023
37327267The SERPINA5 coding variant E228Q does not contribute to clinicopathologic characteristics in Alzheimer's disease: A cross-sectional study.Medicine (Baltimore)2023
34724591Correction to: Apolipoprotein E regulates lipid metabolism and α⿿synuclein pathology in human iPSC⿿derived cerebral organoids.Acta Neuropathol2022
34813500Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions.J Clin Invest2022
33480174Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease.Alzheimers Dement2021
33861770Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies.PLoS One2021
34586832<i>APOE3</i>-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia.Sci Transl Med2021
34453582Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids.Acta Neuropathol2021
33953196Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.Nat Commun2021
34002480Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.Alzheimers Dement2021
33139712APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.Nat Commun2020
31104630Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight.Genome Biol2019
31256143Evaluation of Associations of Alzheimer's Disease Risk Variants that Are Highly Expressed in Microglia with Neuropathological Outcome Measures.J Alzheimers Dis2019
30820047Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.Nat Genet2019
29329552Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.Genome Med2018
30158114TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.J Exp Med2018
30136084Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy.Acta Neuropathol2018
30109269Association study between multiple system atrophy and TREM2 p.R47H.Neurol Genet2018
29458411Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease.Alzheimers Res Ther2018
29107053Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases.Alzheimers Dement2018
27939925A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.Alzheimers Dement2017
28106563Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants.J Alzheimers Dis2017
28480329African American exome sequencing identifies potential risk variants at Alzheimer disease loci.Neurol Genet2017
28183528Transethnic genome-wide scan identifies novel Alzheimer's disease loci.Alzheimers Dement2017
28444230APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.Hum Mol Genet2017
29183403Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience.Genome Med2017
28515043Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides.Circ Res2017
28704393Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study.PLoS One2017
28714976Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.Nat Genet2017
25778476A novel Alzheimer disease locus located near the gene encoding tau protein.Mol Psychiatry2016
26507310Evaluating pathogenic dementia variants in posterior cortical atrophy.Neurobiol Aging2016
27727239Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases.Sci Data2016
27658901TYROBP genetic variants in early-onset Alzheimer's disease.Neurobiol Aging2016
27887626Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains.Mol Neurodegener2016
27115769Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.Acta Neuropathol2016
27374978MAPT haplotype diversity in multiple system atrophy.Parkinsonism Relat Disord2016
27216421Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.Mol Neurodegener2016
27030769ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.J Neurosci2016
27112350Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.Mol Neurodegener2016
25189118Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease.Neurobiol Aging2015
26374899Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).J Biol Chem2015
27066552Late-onset Alzheimer disease risk variants mark brain regulatory loci.Neurol Genet2015
26077951Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.Nat Commun2015
26111938Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice.J Neurochem2015
25681990Blood type gene locus has no influence on ACE association with Alzheimer's disease.Neurobiol Aging2015
25762156Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia.Hum Mol Genet2015
25531812Rarity of the Alzheimer disease-protective APP A673T variant in the United States.JAMA Neurol2015
25217292Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study.Alzheimers Dement2015
23643458Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects.Alzheimers Dement2014
25199842Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.JAMA Neurol2014
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Collaborators

Mayo Clinic Florida
Co-authored papers 71
Mayo Clinic Jacksonville
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Mayo Clinic
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Mayo Clinic
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Mayo Clinic Rochester
Co-authored papers 50
Emory Center for Neurodegenerative Disease
Co-authored papers 32
Mayo Clinic
Co-authored papers 31
Center for Clinical and Translational Science, Mayo Clinic
Co-authored papers 28
Cincinnati Children's Hospital Medical Center
Co-authored papers 27
Mayo Clinic
Co-authored papers 24
Boston University Chobanian & Avedisian School of Medicine
Co-authored papers 21
Mayo Clinic Rochester
Co-authored papers 21
Mayo Clinic
Co-authored papers 20
Brigham Young University
Co-authored papers 20
Icahn School of Medicine at Mount Sinai
Co-authored papers 19
Mayo Clinic
Co-authored papers 19
Mayo Clinic
Co-authored papers 17
Cleveland Institute for Computational Biology, Case Western Reserve University
Co-authored papers 17
Co-authored papers 17
Co-authored papers 16
University of Antwerp
Co-authored papers 16
Mayo Clinic
Co-authored papers 16
Rush University Medical Center
Co-authored papers 15
Cambridge Institute for Medical Research, University of Cambridge
Co-authored papers 15
Mayo Clinic Florida
Co-authored papers 14
University of Washington
Co-authored papers 13
Columbia University Medical Center
Co-authored papers 13
Stanford University
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University of Pittsburgh
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Mayo Clinic
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