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Author Details

Rasmus Jansson-L??fmark
Unit for Pharmacokinetics and Drug Metabolism, University of Gothenburg
2005
46
15
PMIDPaper TitleJournal TitlePublished Year
37993699Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals.Clin Pharmacokinet2024
36988826Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance.Clin Pharmacokinet2023
37711184Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis.Comput Struct Biotechnol J2023
34435745Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity - a non-randomized three-armed controlled trial.Clin Transl Sci2022
35648149Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range.Eur J Clin Pharmacol2022
35404513Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity.Br J Clin Pharmacol2022
36037309Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity.Clin Transl Sci2022
36126230A case-study of model-informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II.CPT Pharmacometrics Syst Pharmacol2022
35158408Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity.Clin Pharmacol Ther2022
35338410Population Pharmacodynamic Modeling of Eflornithine-Based Treatments Against Late-Stage Gambiense Human African Trypanosomiasis and Efficacy Predictions of L-eflornithine-Based Therapy.AAPS J2022
32970864Proteomics-Informed Prediction of Rosuvastatin Plasma Profiles in Patients With a Wide Range of Body Weight.Clin Pharmacol Ther2021
33626278Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.J Am Chem Soc2021
33848634Comparisons of basic target-mediated drug disposition (TMDD) and ligand facilitated target removal (LFTR).Eur J Pharm Sci2021
33667667Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs.Eur J Pharm Sci2021
34252098Enantiospecific antitrypanosomal in vitro activity of eflornithine.PLoS Negl Trop Dis2021
33980578An oral antisense oligonucleotide for PCSK9 inhibition.Sci Transl Med2021
33091408Correlation of Body Weight and Composition With Hepatic Activities of Cytochrome P450 Enzymes.J Pharm Sci2021
32275768Does In Vitro Potency Predict Clinically Efficacious Concentrations?Clin Pharmacol Ther2020
32984708Chiral Chromatographic Isolation on Milligram Scale of the Human African Trypanosomiasis Treatment d- and l-Eflornithine.ACS Omega2020
32359836Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades.Trends Pharmacol Sci2020
30529076Corrigendum to 'Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development' Drug Discovery Today 23 (2018) 1733-1745.Drug Discov Today2019
31410806ADME: Assessing Pharmacokinetic-Pharmacodynamic Parameters of Oligonucleotides.Methods Mol Biol2019
31292220Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia.J Lipid Res2019
30813831The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone.J Renin Angiotensin Aldosterone Syst2019
30596500Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.J Med Chem2019
29468715Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator.Br J Clin Pharmacol2018
29852223Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development.Drug Discov Today2018
30345352Targeted delivery of antisense oligonucleotides to pancreatic β-cells.Sci Adv2018
30564457Mathematical model of hemodynamic mechanisms and consequences of glomerular hypertension in diabetic mice.NPJ Syst Biol Appl2018
30328765Inferring Half-Lives at the Effect Site of Oligonucleotide Drugs.Nucleic Acid Ther2018
29474466Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.PLoS One2018
28754465Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs.Nanomedicine2017
27377054Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates.Diabetes Obes Metab2016
27318707Levodopa-carbidopa intestinal gel (LCIG) treatment in routine care of patients with advanced Parkinson's disease: An open-label prospective observational study of effectiveness, tolerability and healthcare costs.Parkinsonism Relat Disord2016
25512417Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness.Antimicrob Agents Chemother2015
23307171Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the rat.J Pharmacokinet Pharmacodyn2013
24158456A modeling approach for compounds affecting body composition.J Pharmacokinet Pharmacodyn2013
23726890Model-based drug discovery: implementation and impact.Drug Discov Today2013
22690905Interim analysis of long-term intraduodenal levodopa infusion in advanced Parkinson disease.Acta Neurol Scand2012
21046209Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions.J Pharmacokinet Pharmacodyn2011
20020417Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-L-cysteine and liquid chromatography with UV detection.Biomed Chromatogr2010
17724666Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with lipophilicity.J Pharm Sci2008
18519728Enantioselective and nonlinear intestinal absorption of eflornithine in the rat.Antimicrob Agents Chemother2008
16972163Feasibility and validity of a computer administered version of SEIQoL-DW.Qual Life Res2006
15668416Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease.Neurology2005
16275852Long-term 24-hour duodenal infusion of levodopa: outcome and dose requirements.Neurology2005
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Collaborators

Department of Pharmacy, Uppsala University
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Uppsala University
Co-authored papers 4
Sahlgrenska University Hospital
Co-authored papers 3
Department of Biomedical and Clinical Sciences, Linkoping University
Co-authored papers 3
Dept of Clinical Neurosciences, Karolinska Institutet
Co-authored papers 2
Division of Clinical Neuroscience, Umea University
Co-authored papers 2
Department of Neurology Karolinska University Hospital Huddinge Stockholm Sweden.
Co-authored papers 2
Karolinska Institutet
Co-authored papers 2
Skane University Hospital
Co-authored papers 2
Molde Hospital HNR
Co-authored papers 2
Seattle Children's Hospital, University of Washington
Co-authored papers 1
Western Human Nutrition Research Center
Co-authored papers 1
Uppsala University
Co-authored papers 1