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Author Details

J Keith Joung
Massachusetts General Hospital
1993
152
75
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36163548Engineered CRISPR prime editors with compact, untethered reverse transcriptases.Nat Biotechnol2023
37796769Functional analysis of Collagen 17a1: A genetic modifier of junctional epidermolysis bullosa in mice.PLoS One2023
37645936Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions.bioRxiv2023
37292647Gene editing without <i>ex vivo</i> culture evades genotoxicity in human hematopoietic stem cells.bioRxiv2023
37183825Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state.J Clin Invest2023
36909587Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State.bioRxiv2023
33986547Author Correction: CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells.Nat Biotechnol2022
35505961CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease <i>PSEN</i> <i>1</i> M146L mutation.Mol Ther Nucleic Acids2022
35761069Author Correction: Augmenting and directing long-range CRISPR-mediated activation in human cells.Nat Methods2022
36520914Multidimensional control of therapeutic human cell function with synthetic gene circuits.Science2022
35967079Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors.Cell Genom2022
33927418CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells.Nat Biotechnol2022
32661438Optimization of AsCas12a for combinatorial genetic screens in human cells.Nat Biotechnol2021
33547443Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA.Nat Protoc2021
33571044A Code of Ethics for Gene Drive Research.CRISPR J2021
34773119Defining genome-wide CRISPR-Cas genome-editing nuclease activity with GUIDE-seq.Nat Protoc2021
34050017Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito.Proc Natl Acad Sci U S A2021
34354266Augmenting and directing long-range CRISPR-mediated activation in human cells.Nat Methods2021
32541959Publisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.Nat Biotechnol2020
31685652Zebrafish <i>dscaml1</i> Deficiency Impairs Retinal Patterning and Oculomotor Function.J Neurosci2020
32900862Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources.J Immunother Cancer2020
30995674Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.Nature2019
29972722Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize.Plant Biotechnol J2019
31477922CRISPR DNA base editors with reduced RNA off-target and self-editing activities.Nat Biotechnol2019
30867611Adopt a moratorium on heritable genome editing.Nature2019
30742127Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.Nat Biotechnol2019
29326244Gene therapy comes of age.Science2018
29998038Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs.Nat Biomed Eng2018
30190308Discovery of widespread type I and type V CRISPR-Cas inhibitors.Science2018
29858078CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.Mol Ther Nucleic Acids2018
30209390In vivo CRISPR editing with no detectable genome-wide off-target mutations.Nature2018
30059493An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities.Nat Biotechnol2018
29947794Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells.Nucleic Acids Res2018
31021199Impact of Genetic Variation on CRISPR-Cas Targeting.CRISPR J2018
30341435Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq.Nat Protoc2018
30504875CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.Nat Methods2018
29724820Temporal and Spatial Post-Transcriptional Regulation of Zebrafish <i>tie1</i> mRNA by Long Noncoding RNA During Brain Vascular Assembly.Arterioscler Thromb Vasc Biol2018
29600992Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".Nat Methods2018
28576875Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.Blood2017
28415827Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.Oncotarget2017
28459458CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets.Nat Methods2017
29083402Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors.Nat Methods2017
29215332Nodal patterning without Lefty inhibitory feedback is functional but fragile.Elife2017
28931002Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.Nature2017
26735016High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.Nature2016
27231123Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.Cancer Discov2016
27347757Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.Nat Biotechnol2016
27153277Open-source guideseq software for analysis of GUIDE-seq data.Nat Biotechnol2016
27087594Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.Nat Rev Genet2016
25357182Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.Nat Biotechnol2015
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Collaborators

Morgan L Maeder
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 31
Benjamin P Kleinstiver
Center for Genomic Medicine, Massachusetts General Hospital
Co-authored papers 19
Stacey Thibodeau-Beganny
Amherst College
Co-authored papers 16
Luca Pinello
Co-authored papers 13
Matthew H Porteus
Stanford University
Co-authored papers 6
David R Liu
Co-authored papers 5
Sowmya Iyer
Co-authored papers 5
Sara P Garcia
Co-authored papers 4
Shondra M Pruett-Miller
St. Jude Children's Research Hospital.
Co-authored papers 4
Scot A Wolfe
Co-authored papers 4
Anthony J Iafrate
Massachusetts General Hospital
Co-authored papers 4
Bradley E Bernstein
Broad Institute of MIT and Harvard
Co-authored papers 3
Daniel E Bauer
Co-authored papers 3
Alex Look
Dana-Farber Cancer Institute
Co-authored papers 3
Christof von Kalle
Berlin Institute of Health at Charite-Universitatsmedizin Berlin
Co-authored papers 3
Dennis C Sgroi
Co-authored papers 2
Jizhong Zou
and Blood Institute, National Institutes of Health
Co-authored papers 2
Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 2
Vilmantas Giedraitis
Co-authored papers 2
Frederic D Bushman
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Xandra O Breakefield
Massachusetts General Hospital
Co-authored papers 2
John G Doench
Co-authored papers 2
Sharon J Diskin
Children's Hospital of Philadelphia
Co-authored papers 2
Ultan McDermott
Wellcome Sanger Institute
Co-authored papers 2
Martin Ingelsson
Co-authored papers 2
David M Langenau
MGH Pathology and Harvard Medical School
Co-authored papers 2
Feng Zhang
Massachusetts Institute of Technology, USA Broad Institute
Co-authored papers 2
John M Maris
Children's Hospital of Philadelphia
Co-authored papers 2
Shizhen Zhu
Co-authored papers 2
Hanns Lochm??ller
Children's Hospital of Eastern Ontario Research Institute
Co-authored papers 1
Release 1.2