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Author Details

Michael L Whitfield
Geisel School of Medicine at Dartmouth
1995
111
47
PMIDPaper TitleJournal TitlePublished Year
35946522Human dermal fibroblast-derived exosomes induce macrophage activation in systemic sclerosis.Rheumatology (Oxford)2023
37577680CDDO-Methyl Ester Inhibits BRAF Inhibitor Resistance and Remodels the Myeloid Compartment in BRAF-mutant Melanoma.bioRxiv2023
36964674Advances in biological and targeted therapies for systemic sclerosis.Expert Opin Biol Ther2023
37028702Gene Expression Signatures in Inflammatory and Sclerotic Morphea Skin and Sera Distinguish Morphea from Systemic Sclerosis.J Invest Dermatol2023
36708947CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts.J Invest Dermatol2023
35997480Clinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin.Arthritis Care Res (Hoboken)2023
36191640Senescent Cells Accumulate in Systemic Sclerosis Skin.J Invest Dermatol2023
35212485Self-Assembled Human Skin Equivalents Model Macrophage Activation of Cutaneous Fibrogenesis in Systemic Sclerosis.Arthritis Rheumatol2022
35751592A genomic meta-analysis of clinical variables and their association with intrinsic molecular subsets in systemic sclerosis.Rheumatology (Oxford)2022
36355434Machine-learning classification identifies patients with early systemic sclerosis as abatacept responders via CD28 pathway modulation.JCI Insight2022
33164325Reply.Arthritis Rheumatol2021
33654308Moving towards a molecular categorization of autoimmune disease.Nat Rev Rheumatol2021
33663570Correction to: Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.Arthritis Res Ther2021
34502134SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues.Int J Mol Sci2021
34179507Mast Cell Activation in the Systemic Sclerosis Esophagus.J Scleroderma Relat Disord2021
34337154A Case of Recalcitrant Linear Morphea Responding to Subcutaneous Abatacept.J Scleroderma Relat Disord2021
33407866Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.Arthritis Res Ther2021
33028580Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement.Ann Rheum Dis2021
31342624Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator-Initiated, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.Arthritis Rheumatol2020
34966900Safety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial.Lancet Rheumatol2020
31705627Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues.Arthritis Rheumatol2020
33164732Molecular "omic" signatures in systemic sclerosis.Eur J Rheumatol2020
32933919Machine learning predicts stem cell transplant response in severe scleroderma.Ann Rheum Dis2020
32721949Regulator combinations identify systemic sclerosis patients with more severe disease.JCI Insight2020
32336038Safety and Efficacy of Lenabasum in a Phase II, Randomized, Placebo-Controlled Trial in Adults With Systemic Sclerosis.Arthritis Rheumatol2020
32300202CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer.Sci Rep2020
32134204Profibrotic Activation of Human Macrophages in Systemic Sclerosis.Arthritis Rheumatol2020
32134199Current and Future Outlook on Disease Modification and Defining Low Disease Activity in Systemic Sclerosis.Arthritis Rheumatol2020
30568176Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues.Lab Invest2019
31712723Shared and distinct mechanisms of fibrosis.Nat Rev Rheumatol2019
31156645OTUD6B-AS1 Might Be a Novel Regulator of Apoptosis in Systemic Sclerosis.Front Immunol2019
30920766A Machine Learning Classifier for Assigning Individual Patients With Systemic Sclerosis to Intrinsic Molecular Subsets.Arthritis Rheumatol2019
30799505BioMethyl: an R package for biological interpretation of DNA methylation data.Bioinformatics2019
31112009Senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With Senolytic Therapy: Potential Predictor of Clinical Response?Arthritis Rheumatol2019
30728065Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.Arthritis Res Ther2019
29073351Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Double-Blind, Placebo-Controlled, Pilot Trial.Arthritis Rheumatol2018
30498788Patients with systemic sclerosis-associated pulmonary arterial hypertension express a genomic signature distinct from patients with interstitial lung disease.J Scleroderma Relat Disord2018
29391252Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin.J Invest Dermatol2018
29360996Feature specific quantile normalization enables cross-platform classification of molecular subtypes using gene expression data.Bioinformatics2018
29179949Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis.J Invest Dermatol2018
28011145A Functional Genomic Meta-Analysis of Clinical Trials in Systemic Sclerosis: Toward Precision Medicine and Combination Therapy.J Invest Dermatol2017
28330499A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.Genome Med2017
28426704Population effect model identifies gene expression predictors of survival outcomes in lung adenocarcinoma for both Caucasian and Asian patients.PLoS One2017
28202513Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors.Cancer Res2017
29520335The mechanistic implications of gene expression studies in SSc: Insights from Systems Biology.Curr Treatm Opt Rheumatol2017
29121645Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease.PLoS One2017
28676069Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature.Arthritis Res Ther2017
25384965Downregulation of miR-193b in systemic sclerosis regulates the proliferative vasculopathy by urokinase-type plasminogen activator expression.Ann Rheum Dis2016
26555452Molecular stratification and precision medicine in systemic sclerosis from genomic and proteomic data.Curr Opin Rheumatol2016
28018971Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity.JCI Insight2016
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Collaborators

Geisel School of Medicine at Dartmouth
Co-authored papers 28
Geisel School of Medicine at Dartmouth
Co-authored papers 26
Yale School of Medicine
Co-authored papers 17
Larner College of Medicine, University of Vermont
Co-authored papers 11
Dartmouth Geisel School of Medicine
Co-authored papers 11
University of North Carolina at Chapel Hill
Co-authored papers 9
Alex's Lemonade Stand Foundation
Co-authored papers 9
Biomedical and Translational Informatics Institute
Co-authored papers 8
University of Michigan ann arbor
Co-authored papers 6
University of Texas McGovern Medical School
Co-authored papers 5
Baylor College of Medicine
Co-authored papers 5
Calico Life Sciences LLC
Co-authored papers 5
Co-authored papers 4
Center for Personal Dynamic Regulomes, Stanford University
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Institute for Cancer Research, Oslo University Hospital
Co-authored papers 2
Corbus Pharmaceuticals Holdings
Co-authored papers 2
Dartmouth College Geisel School of Medicine, Princeton University, University of Colorado Anschutz Medical Campus, University of Pennsylvania Perelman School of Medicine
Co-authored papers 2
Co-authored papers 2
Baylor College of Medicine
Co-authored papers 2
Toronto Western Hospital, University of Toronto
Co-authored papers 2
University of Michigan ann arbor
Co-authored papers 2
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