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Author Details

Kaylene J Simpson
The University of Melbourne, Peter MacCallum Cancer Centre
1996
109
29
PMIDPaper TitleJournal TitlePublished Year
37657710A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells.SLAS Technol2024
37657710A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells.SLAS Technol2024
36693952The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.Oncogene2023
37771787A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to <sup>177</sup>Lutetium-DOTA-octreotate radionuclide therapy.Theranostics2023
37072858COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.J Exp Clin Cancer Res2023
37191437Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.Cancer Discov2023
37188266Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling.Front Pharmacol2023
36693952The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.Oncogene2023
37371546Using a Quantitative High-Throughput Screening Platform to Identify Molecular Targets and Compounds as Repurposing Candidates for Endometriosis.Biomolecules2023
37355554MAC-Seq: Coupling Low-Cost, High-Throughput RNA-Seq with Image-Based Phenotypic Screening in 2D and 3D Cell Models.Methods Mol Biol2023
37771787A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to <sup>177</sup>Lutetium-DOTA-octreotate radionuclide therapy.Theranostics2023
37191437Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.Cancer Discov2023
37188266Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling.Front Pharmacol2023
37371546Using a Quantitative High-Throughput Screening Platform to Identify Molecular Targets and Compounds as Repurposing Candidates for Endometriosis.Biomolecules2023
37072858COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.J Exp Clin Cancer Res2023
37355554MAC-Seq: Coupling Low-Cost, High-Throughput RNA-Seq with Image-Based Phenotypic Screening in 2D and 3D Cell Models.Methods Mol Biol2023
34464972Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.Blood Adv2022
36103522Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction.Sci Adv2022
35831623Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis.Cell Death Differ2022
35810535Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani.Eur J Med Chem2022
36189423Functional high-throughput screen identifies microRNAs that promote butyrate-induced death in colorectal cancer cells.Mol Ther Nucleic Acids2022
36923279Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer.Cancer Res Commun2022
34464972Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.Blood Adv2022
35232962Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF<sup>V600</sup> melanoma.Nat Commun2022
34998954miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma.Mol Ther2022
35831623Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis.Cell Death Differ2022
35810535Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani.Eur J Med Chem2022
36923279Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer.Cancer Res Commun2022
36103522Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction.Sci Adv2022
36189423Functional high-throughput screen identifies microRNAs that promote butyrate-induced death in colorectal cancer cells.Mol Ther Nucleic Acids2022
34998954miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma.Mol Ther2022
35232962Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF<sup>V600</sup> melanoma.Nat Commun2022
32768338Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells.J Microbiol Immunol Infect2021
34111999High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids.SLAS Discov2021
34004147The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.Cell2021
34050191High-content siRNA 3D co-cultures to identify myoepithelial cell-derived breast cancer suppressor proteins.Sci Data2021
34041837Genome-wide genetic screen identifies host ubiquitination as important for Legionella pneumophila Dot/Icm effector translocation.Cell Microbiol2021
34315763SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than <i>TP53</i> Mutation Status.Mol Cancer Ther2021
32768338Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells.J Microbiol Immunol Infect2021
33314700A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death.EMBO Mol Med2021
33173151The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.Br J Cancer2021
34413130CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition.Mol Cancer Ther2021
34413130CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition.Mol Cancer Ther2021
34041837Genome-wide genetic screen identifies host ubiquitination as important for Legionella pneumophila Dot/Icm effector translocation.Cell Microbiol2021
34315763SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than <i>TP53</i> Mutation Status.Mol Cancer Ther2021
34004147The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.Cell2021
34111999High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids.SLAS Discov2021
34050191High-content siRNA 3D co-cultures to identify myoepithelial cell-derived breast cancer suppressor proteins.Sci Data2021
33314700A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death.EMBO Mol Med2021
33173151The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer.Br J Cancer2021
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Collaborators

Co-authored papers 7
The University of Melbourne
Co-authored papers 7
Co-authored papers 5
Co-authored papers 4
Peter MacCallum Cancer Centre, The University of Melbourne
Co-authored papers 3
Peter MacCallum Cancer Centre
Co-authored papers 3
Biomedicine Discovery Institute, Monash University
Co-authored papers 3
University of Melbourne
Co-authored papers 3
Co-authored papers 3
Institute of Biochemistry, Biological Research Centre
Co-authored papers 3
University of Queensland
Co-authored papers 3
Biomedicine Discovery Institute, Monash University
Co-authored papers 3
The University of Melbourne
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Peter MacCallum Cancer Centre
Co-authored papers 2
Macquarie University
Co-authored papers 2
Co-authored papers 2
Peter MacCallum Cancer Centre
Co-authored papers 2
Co-authored papers 2
Children's Cancer Institute, Lowy Cancer Research Centre
Co-authored papers 2
Co-authored papers 2
Peter MacCallum Cancer Centre
Co-authored papers 2
Co-authored papers 2
Adelaide Medical School, University of Adelaide
Co-authored papers 2
QIMR Berghofer Medical Research Institute
Co-authored papers 2
QIMR Berghofer Medical Research Institute
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Co-authored papers 1