Author details

Full Name

Jason E Cain

Affiliation

ORCID

Career Start Year

2005

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36976863	Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.	Sci Signal	2023
36335802	The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.	Neoplasia	2023
37845394	Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype.	Oncogene	2023
37584601	Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.	Cancer Discov	2023
37145169	ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma.	Cancer Res	2023
37195023	ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma.	Cancer Res	2023
37001527	Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.	Cancer Cell	2023
37517472	Implementation of DNA Methylation Array Profiling in Pediatric Central Nervous System Tumors: The AIM BRAIN Project: An Australian and New Zealand Children's Haematology/Oncology Group Study.	J Mol Diagn	2023
37098540	MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat.	J Exp Clin Cancer Res	2023
34759345	Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies.	Oncogene	2022
35523793	Distinctive molecular features of regenerative stem cells in the damaged male germline.	Nature Communications	2022
34675406	Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium.	Oncogene	2022
35157764	Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.	Neuro Oncol	2022
34680294	Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy.	Cancers (Basel)	2021
33983115	A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma.	Elife	2021
34988452	Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma.	Neurooncol Adv	2021
32605910	Circulating Tumor DNA is Prognostic and Potentially Predictive of Eryaspase Efficacy in Second-line in Patients with Advanced Pancreatic Adenocarcinoma.	Clinical Cancer Research	2020
31738020	Lessons learned from the developmental origins of childhood renal cancer.	Anatomical Record	2020
32743560	Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma.	Cell Rep Med	2020
33235907	p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis.	Mol Cell Oncol	2020
32568216	Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.	J Clin Invest	2020
30833304	ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.	EMBO Mol Med	2019
31683879	A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma.	Cancers (Basel)	2019
30348992	Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.	Oncogene	2019
29109083	Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.	J Am Soc Nephrol	2018
30558637	The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.	Clinical Epigenetics	2018
30045976	Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy.	Sci Transl Med	2018
30464171	Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing.	Nat Commun	2018
29367758	The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.	Oncogene	2018
28974621	Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses.	mBio	2017
28820907	Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo.	PLoS One	2017
28634201	Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes.	Cancer Res	2017
28756741	Modulation of Mitochondrial DNA Copy Number to Induce Hepatocytic Differentiation of Human Amniotic Epithelial Cells.		2017
28581526	The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.	Oncogene	2017
27551510	Mitochondrial DNA plasticity is an essential inducer of tumorigenesis.	Cell Death Discov	2016
27196751	Activating Transcription Factor 3 Expression as a Marker of Response to the Histone Deacetylase Inhibitor Pracinostat.	Molecular Cancer Therapeutics	2016
26740067	The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase.	Mol Hum Reprod	2016
26920892	Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors.	Clin Cancer Res	2016
27269943	Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.	J Clin Oncol	2016
27166376	Cre-dependent DNA recombination activates a STING-dependent innate immune response.	Nucleic Acids Research	2016
26604140	Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.	Human Molecular Genetics	2016
26270676	Hedgehog Signaling in the Maintenance of Cancer Stem Cells.	Cancers (Basel)	2015
24705254	Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.	Nat Genet	2014
25191746	Genomic characterisation of small cell lung cancer patient-derived xenografts generated from endobronchial ultrasound-guided transbronchial needle aspiration specimens.	PLoS One	2014
23335808	Deletions in 16q24.2 are associated with autism spectrum disorder, intellectual disability and congenital renal malformation.	J Med Genet	2013
23240784	Visualizing renal primary cilia.	Nephrology (Carlton)	2013
23533324	Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells.	Sarcoma	2013
22906929	Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma.	Pharmacol Ther	2012
21339645	GLI3 repressor controls functional development of the mouse ureter.	Journal of Clinical Investigation	2011
21436291	Î²-catenin causes renal dysplasia via upregulation of TgfÎ²2 and Dkk1.	Journal of the American Society of Nephrology : JASN	2011