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Author Details

Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
1999
124
48
Sami Nourreddine (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38012306Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting.Nat Biomed Eng2024
37224531Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling.Nucleic Acids Res2023
37559903A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response.iScience2023
37506639Relative Biological Effectiveness (RBE) of [<sup>64</sup>Cu]Cu and [<sup>177</sup>Lu]Lu-NOTA-panitumumab F (ab')<sub>2</sub> radioimmunotherapeutic agents vs. γ-radiation for decreasing the clonogenic survival in vitro of human pancreatic ductal adenocarcinoma (PDAC) cells.Nucl Med Biol2023
37873237CRISPR Screening in Tandem with Targeted mtDNA Damage Reveals WRNIP1 Essentiality.bioRxiv2023
38032106FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe.Cancer Res Commun2023
37321220Targeted alveolar regeneration with Frizzled-specific agonists.Cell2023
37085400Modulation of Wnt-β-catenin signaling with antibodies: therapeutic opportunities and challenges.Trends Pharmacol Sci2023
36989359Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes.Sci Adv2023
37040490Efficient Delivery of Biological Cargos into Primary Cells by Electrodeposited Nanoneedles via Cell-Cycle-Dependent Endocytosis.Nano Lett2023
36967192Wnt signaling in stem cells during development and cell lineage specification.Curr Top Dev Biol2023
34757425The F-box protein Bard (CG14317) targets the Smaug RNA-binding protein for destruction during the Drosophila maternal-to-zygotic transition.Genetics2022
35639489Nanoparticle Amplification Labeling for High-Performance Magnetic Cell Sorting.Nano Lett2022
36589880nuPRISM: Microfluidic Genome-Wide Phenotypic Screening Platform for Cellular Nuclei.ACS Cent Sci2022
36278408SCF<sup>FBXW7</sup> regulates G2-M progression through control of CCNL1 ubiquitination.EMBO Rep2022
36309522CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.Nat Commun2022
35998230Frizzled does not get bent out of shape by Wnt.Sci Signal2022
35867229Identification of Drug Resistance Mechanisms Using Genome-Wide CRISPR-Cas9 Screens.Methods Mol Biol2022
36327972Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964.Structure2022
36054348Genome-wide in vivo screen of circulating tumor cells identifies <i>SLIT2</i> as a regulator of metastasis.Sci Adv2022
36220068Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b.Cell Rep Med2022
35106377Rapid On-Cell Selection of High-Performance Human Antibodies.ACS Cent Sci2022
33427645Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival.Elife2021
33649538The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.Oncogene2021
33787008Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors.EMBO Mol Med2021
35122077Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity.Nat Cancer2021
34105895A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.EMBO Mol Med2021
32369335Nanostructured Architectures Promote the Mesenchymal-Epithelial Transition for Invasive Cells.ACS Nano2020
31910361Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.Dev Cell2020
31881079IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.J Cell Biol2020
32579915Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition.Cell Rep2020
32601235Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.Proc Natl Acad Sci U S A2020
32709883Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Nat Commun2020
32445698Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Cell2020
32160542The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs.Cell Rep2020
30698747ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development.Nucleic Acids Res2019
31761532Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.Cell2019
31548591High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.Nat Biomed Eng2019
31452509Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.Elife2019
30842215Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells.Genes Dev2019
30809805Agonist-induced desensitisation of β<sub>3</sub> -adrenoceptors: Where, when, and how?Br J Pharmacol2019
30894493Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.Proc Natl Acad Sci U S A2019
30995489Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.Cell Rep2019
30554998Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.Dev Cell2019
29395067High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.Mol Cell2018
29973717CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.Nature2018
30183492A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties.MAbs2018
29884654Wnt signaling in development and tissue homeostasis.Development2018
30335391Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction.Nano Lett2018
29728602Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.Nat Chem Biol2018
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Collaborators

Michel Bouvier
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 18
Zachary Steinhart
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 13
Graham MacLeod
University of Toronto
Co-authored papers 13
Sichun Lin
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 13
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 12
Sachdev S Sidhu
School of Pharmacy, University of Waterloo
Co-authored papers 11
Jason Moffat
University of Toronto
Co-authored papers 9
Traver Hart
University of Texas MD Anderson Cancer Center
Co-authored papers 7
Michael D Taylor
The Hospital for Sick Children
Co-authored papers 7
Mathieu Lupien
Princess Margaret Cancer Research Centre
Co-authored papers 6
Paul Guilhamon
The Hospital for Sick Children
Co-authored papers 5
Michael J MacCoss
University of Washington
Co-authored papers 4
Gary D Bader
University of Toronto
Co-authored papers 4
Michael D Cusimano
St. Michael's Hospital, University of Toronto
Co-authored papers 4
Florence M G Cavalli
Institut Curie, PSL Research University
Co-authored papers 4
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 4
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 3
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 3
Stephen C Mack
St Jude Children's Research Hospital
Co-authored papers 3
Ning Zheng
University of Washington
Co-authored papers 3
Quaid Morris
Sloan Kettering Institute
Co-authored papers 3
Hamza Farooq
BioBox Analytics Inc.
Co-authored papers 3
Xi Huang
The Hospital for Sick Children
Co-authored papers 3
Kevin R Brown
College Street, University of Toronto
Co-authored papers 3
Ian D Clarke
Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Co-authored papers 3
Liis Uusk??la-Reimand
SickKids Research Institute
Co-authored papers 2
Jeffrey L Wrana
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Michael B Major
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Release 1.2