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Author Details

Kevin D Rynearson
2010
16
9
PMIDPaper TitleJournal TitlePublished Year
37042072Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.Ann Neurol2023
35084109Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease.Alzheimers Dement2022
33651103Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.J Exp Med2021
33007551Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.Bioorg Med Chem2020
32432881γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.Langmuir2020
31958080The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease.J Alzheimers Dis2020
32936886Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates.Journal of Experimental Medicine2020
28919280Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.eBioMedicine2017
28416568Pharmacological and Toxicological Properties of the Potent Oral <i>γ</i>-Secretase Modulator BPN-15606.J Pharmacol Exp Ther2017
27426299Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.Bioorg Med Chem Lett2016
249308292-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site.Bioorganic and Medicinal Chemistry Letters2014
24401146Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.Biochemistry2014
24138284Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.Journal of Medicinal Chemistry2014
24861167Nanopore-based conformational analysis of a viral RNA drug target.ACS Nano2014
23602522Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.Bioorganic and Medicinal Chemistry2013
200280821,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams.Organic Letters2010
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