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Author Details

Stuart J Blakemore
Center for Molecular Medicine Cologne (CMMC), University of Cologne
2010
28
17
Dexter Pratt (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36179280The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL.Blood2023
37277510Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ.Commun Biol2023
35344582Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies.Blood2022
34725211BT7480, a novel fully synthetic <i>Bicycle</i> tumor-targeted immune cell agonistâ¿¢ (<i>Bicycle</i> TICAâ¿¢) induces tumor localized CD137 agonism.J Immunother Cancer2021
33538798Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.Blood2021
33580200The association between deaths from infection and mutations of the BRAF, FBXW7, NRAS and XPO1 genes: a report from the LRF CLL4 trial.Leukemia2021
34555678Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis.J Autoimmun2021
32824276Macrophage-Mediated Antibody Dependent Effector Function in Aggressive B-Cell Lymphoma Treatment is Enhanced by Ibrutinib via Inhibition of JAK2.Cancers (Basel)2020
32015491Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial.Leukemia2020
30642912Immunologic Correlates of the Abscopal Effect in a SMARCB1/INI1-negative Poorly Differentiated Chordoma after EZH2 Inhibition and Radiotherapy.Clin Cancer Res2019
31434681Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials.Blood Adv2019
29650362Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study.Lancet Oncol2018
29724899The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.Blood2018
27773930Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial.Leukemia2017
28428443Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in <i>MLL</i>-Rearranged Leukemia.Mol Cancer Ther2017
27843137PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis.Leukemia2017
27783255Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924).Invest New Drugs2017
27890934EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.Leukemia2017
26184912BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.Cell Death Differ2016
26488112The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.Leukemia2016
26675346Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.Blood2016
27282254Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.Leukemia2016
26957556Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia.Clin Cancer Res2016
25733005Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study.Br J Haematol2015
24232190Applications of pathology-assisted image analysis of immunohistochemistry-based biomarkers in oncology.Vet Pathol2014
24335104Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy.Blood2014
23633453Disrupting protein NEDDylation with MLN4924 is a novel strategy to target cisplatin resistance in ovarian cancer.Clin Cancer Res2013
20604938Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693.BMC Genomics2010
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Collaborators

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Co-authored papers 2
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University of California San Diego
Co-authored papers 1
AbbVie Bioresearch Center, Inc.
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Duke University Medical Center
Co-authored papers 1
UC San Diego
Co-authored papers 1
tranSMART Foundation
Co-authored papers 1
Oregon Health and Science University
Co-authored papers 1
MD Anderson Cancer Center
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1
Institute for Biomedical Research August Pi I Sunyer
Co-authored papers 1
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University of California San Francisco
Co-authored papers 1
University of California San Diego
Co-authored papers 1
Huntsman Cancer Institute, The University of Utah
Co-authored papers 1
AbbVie Inc.
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
Boston Children's Hospital
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Center for Applied Proteomics and Molecular Medicine, George Mason University
Co-authored papers 1
FOG Pharmaceuticals Inc.
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German Cancer Research Center
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Novartis Institutes for Biomedical
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Dana Farber Cancer Institute
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