Author details

Full Name

David Heckerman

Affiliation

ORCID

Career Start Year

1990

Papers

124

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36853602	Acute and Postacute COVID-19 Outcomes Among Immunologically Naive Adults During Delta vs Omicron Waves.		2023
36425923	Acute and Post-Acute COVID-19 Outcomes Among Immunologically NaÃ¯ve Adults During Delta Versus Omicron Waves.		2022
31675503	Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.	Cell	2019
31748530	Ranking of non-coding pathogenic variants and putative essential regions of the human genome.	Nat Commun	2019
31782791	Assembly of the 373k gene space of the polyploid sugarcane genome reveals reservoirs of functional diversity in the world's leading biomass crop.	Gigascience	2019
29989981	Ensembles of Lasso Screening Rules.		2018
30297971	Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.	Nat Genet	2018
30425353	Publisher Correction: Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.	Nat Genet	2018
29158487	Genetic variants associated with physical performance and anthropometry in old age: a genome-wide association study in the ilSIRENTE cohort.	Sci Rep	2017
29100084	Profiling of Short-Tandem-Repeat Disease Alleles in 12,632 Human Whole Genomes.	Am J Hum Genet	2017
27183217	Impact of pre-adapted HIV transmission.	Nat Med	2016
27382152	Linear mixed model for heritability estimation that explicitly addresses environmental variation.	Proceedings of the National Academy of Sciences of the United States of America	2016
26107956	Anti-hepatitis C virus T-cell immunity in the context of multiple exposures to the virus.	PLoS ONE	2015
25589651	Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1.	Journal of Virology	2015
25880203	ConPADE: genome assembly ploidy estimation from next-generation sequencing data.	PLoS Computational Biology	2015
25664543	Accurate liability estimation improves power in ascertained case-control studies.	Nature Methods	2015
25165102	Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome.	J Virol	2014
25387525	Further improvements to linear mixed models for genome-wide association studies.	Scientific Reports	2014
24227851	Increased sequence coverage through combined targeting of variant and conserved epitopes correlates with control of HIV replication.	J Virol	2014
24464286	Epigenome-wide association studies without the need for cell-type composition.	Nature Methods	2014
24681218	Differential T-cell responses of semi-immune and susceptible malaria subjects to in silico predicted and synthetic peptides of Plasmodium falciparum.	Acta Tropica	2014
24912025	Eliciting cytotoxic T-lymphocyte responses from synthetic vectors containing one or two epitopes in a C57BL/6 mouse model using peptide-containing biodegradable microspheres and adjuvants.	Vaccine	2014
24670270	Quantifying the uncertainty in heritability.	Journal of Human Genetics	2014
24939151	Literome: PubMed-scale genomic knowledge base in the cloud.		2014
25013080	HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck.	Science	2014
25075117	Greater power and computational efficiency for kernel-based association testing of sets of genetic variants.		2014
25165115	HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes.	J Virol	2014
23365420	Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteins.	Journal of Virology	2013
24023819	Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.	PLoS One	2013
24171102	A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.	Elife	2013
23599503	A powerful and efficient set test for genetic markers that handles confounders.		2013
23276808	HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes.	AIDS	2013
23152532	Significant reductions in Gag-protease-mediated HIV-1 replication capacity during the course of the epidemic in Japan.	Journal of Virology	2013
23233659	High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.	Blood	2013
23559252	Influence of HLA-C expression level on HIV control.	Science	2013
23555935	HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice.	PLoS One	2013
23303775	Patterns of methylation heritability in a genome-wide analysis of four brain regions.	Nucleic Acids Res	2013
23619783	FaST-LMM-Select for addressing confounding from spatial structure and rare variants.	Nature Genetics	2013
23657357	The benefits of selecting phenotype-specific variants for applications of mixed models in genomics.	Sci Rep	2013
22031937	HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome.	J Virol	2012
22973023	Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.	J Virol	2012
22586449	Learning transcriptional regulatory relationships using sparse graphical models.	PLoS One	2012
22496233	Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity.	J Virol	2012
22379086	Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.	J Virol	2012
22718199	Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans.	Hum Mol Genet	2012
22669648	Improved linear mixed models for genome-wide association studies.	Nature Methods	2012
23055555	Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.	J Virol	2012
23094091	Co-operative additive effects between HLA alleles in control of HIV-1.	PLoS One	2012
23209412	Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.	PLoS Pathog	2012
23029237	Improved learning in U.S. history and decision competence with decision-focused curriculum.	PLoS ONE	2012