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Author Details

Matthias Wittwer
F. Hoffmann-La Roche Ltd.
1997
82
30
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37113234Phylogeography of <i>Francisella tularensis</i> subspecies <i>holarctica</i> and epidemiology of tularemia in Switzerland.Front Microbiol2023
38052772A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.Nat Commun2023
35322806Targeted protein degraders: a call for collective action to advance safety assessment.Nat Rev Drug Discov2022
35561119Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.Clin Pharmacol Ther2022
35687098Considerations and recommendations for assessment of plasma protein binding and drug-drug interactions for siRNA therapeutics.Nucleic Acids Res2022
36414482Influence of Chlorinating Agents on the Formation of Stable Biomarkers in Hair for the Retrospective Verification of Exposure.Anal Chem2022
36137365Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain.Eur J Med Chem2022
36084029A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.PLoS One2022
36385748Diagnostic challenges within the <i>Bacillus cereus-</i>group: finding the beast without teeth.New Microbes New Infect2022
35248850Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold.Nucl Med Biol2022
35089028Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging.J Med Chem2022
33509986Whole-Genome Assemblies of 16 Burkholderia pseudomallei Isolates from Rivers in Laos.Microbiol Resour Announc2021
32393901Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice.Nat Chem Biol2020
31682986Antimicrobial resistance classification using MALDI-TOF-MS is not that easy: lessons from vancomycin-resistant Enterococcus faecium.Clin Microbiol Infect2020
33003104Tularemia in Children and Adolescents.Pediatr Infect Dis J2020
32739889Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction.Drug Metab Dispos2020
32922859Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration.NPJ Genom Med2020
32298797Fundamental aspects of DMPK optimization of targeted protein degraders.Drug Discov Today2020
32453569Structure-Permeability Relationship of Semipeptidic Macrocycles-Understanding and Optimizing Passive Permeability and Efflux Ratio.J Med Chem2020
30760771Draft Genome Sequence of Chromatium okenii Isolated from the Stratified Alpine Lake Cadagno.Sci Rep2019
31690847Nanopore sequencing improves the draft genome of the human pathogenic amoeba Naegleria fowleri.Sci Rep2019
29914012Quantitative impact analysis of remote ischemic conditioning and capsaicin application on human skin microcirculation.Clin Hemorheol Microcirc2019
31357988An unusual case of bovine anthrax in the canton of Jura, Switzerland in 2017.BMC Vet Res2019
30891015Mixotrophic Growth Under Micro-Oxic Conditions in the Purple Sulfur Bacterium "<i>Thiodictyon syntrophicum</i>".Front Microbiol2019
29268036Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.Am J Respir Cell Mol Biol2018
30185166The genome of Naegleria lovaniensis, the basis for a comparative approach to unravel pathogenicity factors of the human pathogenic amoeba N. fowleri.BMC Genomics2018
30091177Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance.Clin Pharmacol Ther2018
29774086Complete genome sequence of "<i>Thiodictyon syntrophicum</i>" sp. nov. strain Cad16<sup>T</sup>, a photolithoautotrophic purple sulfur bacterium isolated from the alpine meromictic Lake Cadagno.Stand Genomic Sci2018
29761830ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.Clin Pharmacol Ther2018
29623260Population Genomics of <i>Francisella tularensis</i> subsp. <i>holarctica</i> and its Implication on the Eco-Epidemiology of Tularemia in Switzerland.Front Cell Infect Microbiol2018
28562037Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.J Chem Inf Model2017
27632081Chemical shift assignment of the intrinsically disordered N-terminus and the rubredoxin domain in the folded metal bound and unfolded oxidized state of mycobacterial protein kinase G.Biomol NMR Assign2016
28348839Long-range dispersal moved <i>Francisella tularensis</i> into Western Europe from the East.Microb Genom2016
26597253The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.Clin Pharmacokinet2016
27810897Oxidative Unfolding of the Rubredoxin Domain and the Natively Disordered N-terminal Region Regulate the Catalytic Activity of Mycobacterium tuberculosis Protein Kinase G.J Biol Chem2016
25485598A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.Pharmacogenet Genomics2015
26438077Development of a bead-based Luminex assay using lipopolysaccharide specific monoclonal antibodies to detect biological threats from Brucella species.BMC Microbiol2015
26063856Identification of Highly Pathogenic Microorganisms by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry: Results of an Interlaboratory Ring Trial.J Clin Microbiol2015
25839674Expression and purification of the natively disordered and redox sensitive metal binding regions of Mycobacterium tuberculosis protein kinase G.Protein Expr Purif2015
24462329pKa determination by ¹H NMR spectroscopy - an old methodology revisited.J Pharm Biomed Anal2014
24950717Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri.BMC Genomics2014
24675964Mycobacterium ulcerans persistence at a village water source of Buruli ulcer patients.PLoS Negl Trop Dis2014
23140242Renal transporters in drug development.Annu Rev Pharmacol Toxicol2013
23977941Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis.BMC Infect Dis2013
23601644Chemical development of intracellular protein heterodimerizers.Chem Biol2013
23469000Identification of cryptic Anopheles mosquito species by molecular protein profiling.PLoS One2013
23241029Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.J Med Chem2013
21990163From a library of MAG antagonists to nanomolar CD22 ligands.ChemMedChem2012
22932902High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.J Biol Chem2012
22878396Development of a high- versus low-pathogenicity model of the free-living amoeba Naegleria fowleri.Microbiology (Reading)2012
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Collaborators

Kathleen M Giacomini
University of California San Francisco
Co-authored papers 8
Ludovic Collin
F. Hoffmann-La Roche Ltd
Co-authored papers 4
Arik A Zur
Schools of Pharmacy and Medicine, University of California san francisco
Co-authored papers 3
Bernd Kuhn
Co-authored papers 3
Sonja A Dames
Technische Universitat Munchen
Co-authored papers 3
Natalia Khuri
Stanford University
Co-authored papers 3
Sook Wah Yee
University of California San Francisco
Co-authored papers 3
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 3
Kari M Morrissey
Amunix Pharmaceuticals
Co-authored papers 2
Xuexiang Zhang
Baruch S. Blumberg Institute
Co-authored papers 2
Amber Dahlin
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 2
Roger Stephan
Ontario Institute for Cancer Research
Co-authored papers 2
Yong Huang
Collegeville
Co-authored papers 2
Alan Kosaka
Roche Palo Alto LLC
Co-authored papers 1
Hao Fan
College of Biotechnology and Bioengineering, Zhejiang University of Technology
Co-authored papers 1
Daniel Ricklin
Co-authored papers 1
Lawrence Lin
University of California San Francisco
Co-authored papers 1
Yasuto Kido
Shionogi & Co.
Co-authored papers 1
Matthew W Buczynski
Co-authored papers 1
Mark T Gladwin
University of Maryland School of Medicine
Co-authored papers 1
Benjamin F Cravatt
Scripps Research Institute
Co-authored papers 1
Richard A Castro
University of California san francisco
Co-authored papers 1
Mary F Paine
Washington State University
Co-authored papers 1
Avner Schlessinger
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Co-authored papers 1
David Leppert
Biomedicine and Clinical Research, University Hospital Basel, University of Basel
Co-authored papers 1
Xiaomin Liang
Gilead Sciences Inc.
Co-authored papers 1
Jonathan M Woo
University of California san francisco
Co-authored papers 1
Massimiliano Bonomi
Institut Pasteur, Universite Paris Cite, CNRS UMR 8
Co-authored papers 1
Release 1.2