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Author Details

Joel L Sussman
Weizmann Institute of Science
1971
265
79
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36130731A fish herpesvirus highlights functional diversities among Zα domains related to phase separation induction and A-to-Z conversion.Nucleic Acids Res2023
37860961The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.Acta Crystallogr D Struct Biol2023
37092778Do "Newly Born" orphan proteins resemble "Never Born" proteins? A study using three deep learning algorithms.Proteins2023
36808692Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.FEBS J2023
34080750A practical guide to teaching with Proteopedia.Biochem Mol Biol Educ2021
33686648Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.Protein Sci2021
33559605IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.Acta Crystallogr D Struct Biol2021
32155891A Second Look at the Crystal Structures of <i>Drosophila melanogaster</i> Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides.Molecules2020
32087110Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers.Chem Biol Interact2020
31873734Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.Mol Biol Evol2020
32795461Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function.Neuropharmacology2020
32566135A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community).F1000Res2020
30447434Novel multitarget-directed ligands targeting acetylcholinesterase and Ï¿<sub>1</sub> receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.Eur J Med Chem2019
31824649An intrinsically disordered proteins community for ELIXIR.F1000Res2019
31202688The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.Chem Biol Interact2019
31226285Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design.Chem Biol Interact2019
31152679Flexible regions govern promiscuous binding of IL-24 to receptors IL-20R1 and IL-22R1.FEBS J2019
30798053Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.Eur J Med Chem2019
28714803Comparing NMR and X-ray protein structure: Lindemann-like parameters and NMR disorder.J Biomol Struct Dyn2018
30125110Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.J Med Chem2018
30538207Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly.Proc Natl Acad Sci U S A2018
29672968Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.Chemistry2018
29677494Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.Mol Cell2018
28796192Computational Studies on Acetylcholinesterases.Molecules2017
28159998Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.Protein Eng Des Sel2017
28503857Recent developments in structural studies on acetylcholinesterase.J Neurochem2017
26990888The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.Protein Sci2016
26612364Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.Arch Toxicol2016
27397758Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection.Toxicol Lett2016
27425410Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.Mol Cell2016
27163850In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.Chem Biol Interact2016
25644661Catalytic stimulation by restrained active-site floppiness--the case of high density lipoprotein-bound serum paraoxonase-1.J Mol Biol2015
24174539pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins.Nucleic Acids Res2014
25195526Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study.Toxicol Lett2014
24477626Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro.Arch Toxicol2014
23318950Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme.J Mol Biol2013
28516007What's in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered.Intrinsically Disord Proteins2013
23159732The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy.Chem Biol Interact2013
21647611Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3.Biomol NMR Assign2012
22442219Structure of recombinant human carboxylesterase 1 isolated from whole cabbage looper larvae.Acta Crystallogr Sect F Struct Biol Cryst Commun2012
22520752Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.Chem Biol2012
22674800Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase.Protein Sci2012
22306579Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.Nat Chem Biol2012
22419598Acetylcholinesterase: substrate traffic and inhibition.Biochem Mol Biol Educ2012
22387469Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1.J Mol Biol2012
22194329Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.Acta Crystallogr D Biol Crystallogr2012
21217689Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.Nat Chem Biol2011
21807078In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.Toxicol Lett2011
21594947Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations.Protein Sci2011
21619933From SPINE to SPINE-2 complexes and beyond.J Struct Biol2011
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Collaborators

Jaime Prilusky
Weizmann Institute of Science
Co-authored papers 23
Orly Dym
Weizmann Institute of Science
Co-authored papers 18
Yoav Peleg
Weizmann Institute of Science
Co-authored papers 12
Shira Albeck
Weizmann Institute of Science
Co-authored papers 11
Tamar Unger
Weizmann Institute of Science
Co-authored papers 10
Jacques-Philippe Colletier
Co-authored papers 9
Hualiang Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Co-authored papers 8
Tom L Blundell
Heartand Lung Research Institute, University of Cambridge
Co-authored papers 8
Ettore Appella
Co-authored papers 7
Sung-Hou Kim
University of California berkeley
Co-authored papers 7
Udo Heinemann
Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC)
Co-authored papers 6
Peter Tompa
VIB-VUB Center for Structural Biology
Co-authored papers 5
David I Stuart
University of Oxford
Co-authored papers 5
Eran Hodis
Co-authored papers 5
Jacques S Beckmann
University of Lausanne
Co-authored papers 4
Sarel J Fleishman
Co-authored papers 4
Helen M Berman
The State University of New Jersey
Co-authored papers 4
Alan Keith Dunker
Center for Computational Biology, Indiana University School of Medicine
Co-authored papers 4
John Moult
Institute for Bioscience and Biotechnology Research
Co-authored papers 4
George M Church
Harvard Medical School
Co-authored papers 3
Christopher L Morton
St. Jude Children's Research Hospital.
Co-authored papers 3
Raymond J Owens
University of Oxford
Co-authored papers 3
Dawei Lin
College of Fisheries, Tianjin Agricultural University
Co-authored papers 3
James Andrew McCammon
Co-authored papers 3
Ruth Nussinov
Sackler School of Medicine, Tel Aviv University
Co-authored papers 3
Dmitri I Svergun
King's College London BHF Centre for Research Excellence
Co-authored papers 3
David Baker
University of Washington
Co-authored papers 3
Patrick Masson
carnegie mellon university
Co-authored papers 3
Dino Moras
Laboratory IGBMC (Institute of Genetics and of Molecular and Cellular Biology)
Co-authored papers 3
Vladimir N Uversky
Morsani College of Medicine, University of South Florida
Co-authored papers 3
Release 1.2