Author details

Full Name

Tyler Jacks

Affiliation

ORCID

Career Start Year

1985

Papers

346

H Index

139

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37425692	Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis.		2023
37059105	Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma.		2023
37169967	A prime editor mouse to model a broad spectrum of somatic mutations in vivo.		2023
35114133	Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities.	Lancet Oncol	2022
35523183	Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution.	Cell	2022
35902743	Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.	Nat Genet	2022
35705813	Deciphering the immunopeptidome in vivo reveals new tumour antigens.	Nature	2022
34912115	Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.	Nature	2022
34561242	<i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung.	Cancer Discov	2022
35017504	A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.	Nat Commun	2022
34584084	Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice.	Nat Commun	2021
34074758	Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration.	Proceedings of the National Academy of Sciences of the United States of America	2021
33632928	Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection.	Clin Cancer Res	2021
34162553	The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain.	Science advances	2021
34099555	Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads.	Proceedings of the National Academy of Sciences of the United States of America	2021
34142101	Protocol for single-cell ATAC sequencing using combinatorial indexing in mouse lung adenocarcinoma.	STAR Protoc	2021
34344693	Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer.	Cancer Discov	2021
34358448	The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer.	Cancer Cell	2021
32719479	Inducible de novo expression of neoantigens in tumor cells and mice.	Nature Biotechnology	2021
34404785	Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes.	Nat Commun	2021
34738089	Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.	Nature Cancer	2021
34890551	Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.	Cell	2021
34534464	Antigen dominance hierarchies shape TCF1<sup>+</sup> progenitor CD8 TÂ cell phenotypes in tumors.	Cell	2021
34534439	Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1<sup>+</sup> CD8<sup>+</sup> TÂ cells in tumor-draining lymph nodes.	Immunity	2021
34480027	Publisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes.	Nat Commun	2021
34414377	Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1.	Nature Cancer	2020
32304665	Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.	Cell	2020
32238573	Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling.	Sci Transl Med	2020
31871154	CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer.	Proceedings of the National Academy of Sciences of the United States of America	2020
32709715	The Genomic Landscape of <i>SMARCA4</i> Alterations and Associations with Outcomes in Patients with Lung Cancer.	Clin Cancer Res	2020
32707078	Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.	Cancer Cell	2020
32707077	Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.	Cancer Cell	2020
32648540	Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.	eLife	2020
35121957	Publisher Correction: Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1.	Nature Cancer	2020
31292548	Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.	Nature	2019
31801068	IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development.	Cell Rep	2019
31694929	Identification of DHODH as a therapeutic target in small cell lung cancer.	Science Translational Medicine	2019
31213460	Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.	Clin Cancer Res	2019
30674677	Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer.	Proc Natl Acad Sci U S A	2019
30712876	Commensal Microbiota Promote Lung Cancer Development via Î³Î´ T Cells.	Cell	2019
31409707	Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation.	Proceedings of the National Academy of Sciences of the United States of America	2019
29279356	Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells.	Cancer Res	2018
30290244	Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes.	J Control Release	2018
30097486	iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer.	Mol Cancer Ther	2018
30325853	Intercepting Pancreatic Cancer: Our Dream Team's Resolve to Stop Pancreatic Cancer.	Pancreas	2018
29854399	Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.		2018
29533667	Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer.	Nano Letters	2018
29300388	Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.	Nat Protoc	2018
29061961	Survival of pancreatic cancer cells lacking KRAS function.	Nature Communications	2017
28637695	Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.	Genes Dev	2017