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Author Details

Jason Gertz
Huntsman Cancer Institute, University of Utah
2003
71
33
PMIDPaper TitleJournal TitlePublished Year
36993565<i>Cis</i>-regulatory control of transcriptional timing and noise in response to estrogen.bioRxiv2024
36930677TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding.PLoS Biol2023
37275275Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs.NAR Cancer2023
37071732Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification.Sci Signal2023
37363949Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha-Mutant Endometrial Cancer.Mol Cancer Res2023
36930833FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer.Mol Cancer Res2023
34780648MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis.Blood2022
35659930Comprehensive evaluation and efficient classification of BRCA1 RING domain missense substitutions.Am J Hum Genet2022
36396974Characterization of HCI-EC-23 a novel estrogen- and progesterone-responsive endometrial cancer cell line.Sci Rep2022
35221336A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology.Nat Cancer2022
35078818Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis.Cancer Res2022
32826305Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4.Gut2021
33850013Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma.Proc Natl Acad Sci U S A2021
34880227A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer.Nat Commun2021
34553212Genetic demultiplexing of pooled single-cell RNA-sequencing samples in cancer facilitates effective experimental design.Gigascience2021
33184109Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects.Cancer Res2021
33184106Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of <i>ESR1</i>-Mutant Breast Cancer.Cancer Res2021
33294922A Positive Feedback Loop Between TGFβ and Androgen Receptor Supports Triple-negative Breast Cancer Anoikis Resistance.Endocrinology2021
32479598Regulatory sharing between estrogen receptor α bound enhancers.Nucleic Acids Res2020
32046982ETV4 Is Necessary for Estrogen Signaling and Growth in Endometrial Cancer Cells.Cancer Res2020
32004313XPRESSyourself: Enhancing, standardizing, and automating ribosome profiling computational analyses yields improved insight into data.PLoS Comput Biol2020
32473656MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate.Cancer Cell2020
32460686Synergistic CRISPRa-Regulated Chondrogenic Extracellular Matrix Deposition Without Exogenous Growth Factors.Tissue Eng Part A2020
31140325Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc Degeneration.Hum Gene Ther2019
31649055FFPEcap-seq: a method for sequencing capped RNAs in formalin-fixed paraffin-embedded samples.Genome Res2019
31532389NHR-14 loss of function couples intestinal iron uptake with innate immunity in <i>C. elegans</i> through PQM-1 signaling.Elife2019
31570515Sufficiency analysis of estrogen responsive enhancers using synthetic activators.Life Sci Alliance2019
31362937Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer.Genome Res2019
30712080Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions.Horm Cancer2019
31164374MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion.Clin Cancer Res2019
29309061GIGGLE: a search engine for large-scale integrated genome analysis.Nat Methods2018
29912188Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines.J Vis Exp2018
30332632The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.Immunity2018
29539426Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer.Cell Rep2018
28030809Genomic regulation of invasion by STAT3 in triple negative breast cancer.Oncotarget2017
28089889MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition.Cancer Cell2017
28964699Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor α-Bound Enhancers.Cell Syst2017
28676344CRISPR Epigenome Editing of AKAP150 in DRG Neurons Abolishes Degenerative IVD-Induced Neuronal Activation.Mol Ther2017
28754123Post-mortem molecular profiling of three psychiatric disorders.Genome Med2017
26787654Multigene testing of moderate-risk genes: be mindful of the missense.J Med Genet2016
27565181Cooperative Dynamics of AR and ER Activity in Breast Cancer.Mol Cancer Res2016
27282075RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4.Mol Oncol2016
27401066Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation.Genome Med2016
26795348Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus.Cancer Res2016
25890236Improved survival among colon cancer patients with increased differentially expressed pathways.BMC Med2015
26486725Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites.Genome Res2015
24299736From single-cell to cell-pool transcriptomes: stochasticity in gene expression and RNA splicing.Genome Res2014
24929677Recurrent read-through fusion transcripts in breast cancer.Breast Cancer Res Treat2014
23325432Dynamic DNA methylation across diverse human cell lines and tissues.Genome Res2013
24279905Mapping genome-wide transcription factor binding sites in frozen tissues.Epigenetics Chromatin2013
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Collaborators

HudsonAlpha Institute for Biotechnology
Co-authored papers 23
Huntsman Cancer Institute, The University of Utah
Co-authored papers 18
Huntsman Cancer Institute
Co-authored papers 16
Huntsman Cancer Institute
Co-authored papers 14
Co-authored papers 9
Co-authored papers 7
Co-authored papers 7
Center for Genomic & Computational Biology, Duke University
Co-authored papers 5
Washington University School of Medicine
Co-authored papers 4
Co-authored papers 4
Duke University
Co-authored papers 4
Merkin Institute for Translational Research, California Institute of Technology
Co-authored papers 4
Co-authored papers 4
University of Utah
Co-authored papers 3
Co-authored papers 3
HudsonAlpha Institute for Biotechnology
Co-authored papers 3
Co-authored papers 3
National University Hospital
Co-authored papers 3
Co-authored papers 3
University of Alabama at Birmingham
Co-authored papers 3
Altius Institute for Biomedical Sciences
Co-authored papers 3
Boulder and BioFrontiers Institute, University of Colorado Boulder
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Center for Genomic & Computational Biology, Duke University
Co-authored papers 2
Co-authored papers 2
University of Utah
Co-authored papers 2
Stanford University.
Co-authored papers 2
Yale University
Co-authored papers 2