Author details

Full Name

Sylvie Le Gall

Affiliation

ORCID

Career Start Year

1993

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
33075106	A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.	PLoS Pathogens	2020
32196533	Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells.	PLoS Pathogens	2020
30936293	The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner.	Journal of Immunology	2019
29636181	Antigen processing and presentation in HIV infection.	Molecular Immunology	2019
30943397	HIV Controllers Exhibit Effective CD8<sup>+</sup> T Cell Recognition of HIV-1-Infected Non-activated CD4<sup>+</sup> T Cells.	Cell Rep	2019
29915023	Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability.	Cancer Immunology Research	2018
29055006	Posttranscriptional Regulation of HLA-A Protein Expression by Alternative Polyadenylation Signals Involving the RNA-Binding Protein Syncrip.	J Immunol	2017
28678607	HIV Env conserved element DNA vaccine alters immunodominance in macaques.	Human Vaccines and Immunotherapeutics	2017
26828202	A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.	PLoS Pathog	2016
27440904	Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses.	J Virol	2016
27009491	HIV Protease Inhibitor-Induced Cathepsin Modulation Alters Antigen Processing and Cross-Presentation.	Journal of Immunology	2016
26288719	In vitro evaluation of digestive and endolysosomal enzymes to cleave CML-modified Ara h 1 peptides.	Food Science and Nutrition	2015
25781895	Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.	PLoS Pathogens	2015
25605720	The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.	J Biol Chem	2015
26519527	Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-Î± Production in Women.	J Immunol	2015
24616479	Sequence-specific alterations of epitope production by HIV protease inhibitors.	Journal of Immunology	2014
23846565	Susceptibility to CD8 T-cell-mediated killing influences the reservoir of latently HIV-1-infected CD4 T cells.	Journal of acquired immune deficiency syndromes (1999)	2014
24465991	Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.	PLoS One	2014
25230751	Different antigen-processing activities in dendritic cells, macrophages, and monocytes lead to uneven production of HIV epitopes and affect CTL recognition.	Journal of Immunology	2014
25196483	Mechanisms of HIV protein degradation into epitopes: implications for vaccine design.	Viruses	2014
23555935	HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice.	PLoS One	2013
23937268	A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells.	BMC Cell Biology	2013
24060536	A real-time killing assay to follow viral epitope presentation to CD8 T cells.	Journal of Immunological Methods	2013
23740989	HIV-1 gag cytotoxic T lymphocyte epitopes vary in presentation kinetics relative to HLA class I downregulation.	Journal of Virology	2013
22586036	Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.	J Immunol	2012
21555856	Variable HIV peptide stability in human cytosol is critical to epitope presentation and immune escape.	Journal of Clinical Investigation	2011
21151101	Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.	Nature Immunology	2011
21051598	The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.	Science	2010
19505257	Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition.	J Infect Dis	2009
19365081	IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.	Blood	2009
19343217	Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.	PLoS Pathogens	2009
18317010	Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.	AIDS	2008
17975674	Portable flanking sequences modulate CTL epitope processing.	J Clin Invest	2007
17906628	Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.	Nat Immunol	2007
17804494	Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.	Journal of Virology	2007
16249391	Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.	Blood	2006
15781581	Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.	Journal of Experimental Medicine	2005
15745859	Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics.	Trends in Immunology	2005
15067030	Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.	J Exp Med	2004
15194783	Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.	J Virol	2004
14617815	The endoplasmic reticulum membrane is permeable to small molecules.	Molecular Biology of the Cell	2004
11231634	MHC-I-restricted presentation of HIV-1 virion antigens without viral replication.	Nat Med	2001
11593029	HIV-1 Nef impairs MHC class II antigen presentation and surface expression.	Proc Natl Acad Sci U S A	2001
11264386	Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.	J Virol	2001
10982373	Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.	J Virol	2000
10799608	Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions.	J Virol	2000
10399064	The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors.	Immunol Rev	1999
9586638	Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules.	Immunity	1998
9207008	HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication.	J Exp Med	1997
9123874	Human immunodeficiency virus type I Nef independently affects virion incorporation of major histocompatibility complex class I molecules and virus infectivity.	Virology	1997