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Author Details

Lawrence S B Goldstein
university of california san diego
1975
226
88
PMIDPaper TitleJournal TitlePublished Year
36399267Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease.Methods Mol Biol2023
33296223Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization.Mol Biol Cell2021
33910058Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients.Cell Stem Cell2021
34377737Evidence generation and reproducibility in cell and gene therapy research: A call to action.Mol Ther Methods Clin Dev2021
34663629Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons.J Neurosci2021
33453937The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention?Prog Mol Biol Transl Sci2021
33446531Stem cells on the ballot.Science2021
33417866Balancing Scientific Advice with Political Realities during the Campaign to Pass California's Ballot Proposition 14.Cell Stem Cell2021
31780819Amyloid-β-independent regulators of tau pathology in Alzheimer disease.Nat Rev Neurosci2020
30655416Why we need fetal tissue research.Science2019
31740836Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells.Nat Genet2019
29503090Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.Stem Cell Reports2018
29858247Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.J Biol Chem2018
28410643High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells.Stem Cell Reports2017
28410642iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.Stem Cell Reports2017
27732852Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.Cell Rep2016
25392299Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.Mol Biol Cell2015
26330437Mechanical Ventilation Antioxidant Trial.Am J Crit Care2015
25710536Cellular functions of the amyloid precursor protein from development to dementia.Dev Cell2015
25710492A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.PLoS One2015
25772071Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.Cell Stem Cell2015
25534395Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology.Neurotherapeutics2015
24702007Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration.Annu Rev Biophys2014
25406537Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis.J Vis Exp2014
25285942Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers.JAMA Neurol2014
25123310Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury.Neuron2014
24522182Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function.J Cell Sci2014
24573290UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.J Neurosci2014
23275297ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.Proc Natl Acad Sci U S A2013
24145027Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.J Biol Chem2013
24239350The presenilin-1 οE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.Cell Rep2013
23840848The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila.PLoS One2013
23644381Regulation of stem cell therapies under attack in Europe: for whom the bell tolls.EMBO J2013
23710041Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.Hum Mol Genet2013
23472870Position statement on the provision and procurement of human eggs for stem cell research.Cell Stem Cell2013
23333150A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.Cell Stem Cell2013
23279138Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein.Traffic2013
22398725Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila.Mol Biol Cell2012
23397530Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver.Semin Liver Dis2012
22936697An October call to arms: we are research!Mol Biol Cell2012
23018948US election: Know your representatives.Nature2012
23148231New frontiers in human cell biology and medicine: can pluripotent stem cells deliver?J Cell Biol2012
22865875Alzheimer's disease in a dish: promises and challenges of human stem cell models.Hum Mol Genet2012
22843498Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.Hum Mol Genet2012
22484448Axonal transport and neurodegenerative disease: can we see the elephant?Prog Neurobiol2012
22437840Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1.Hum Mol Genet2012
22582169Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles.Proc Natl Acad Sci U S A2012
22278060Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.Nature2012
22272245Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism.PLoS One2012
21278334Investigating synapse formation and function using human pluripotent stem cell-derived neurons.Proc Natl Acad Sci U S A2011
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Collaborators

Shauna H Yuan
Co-authored papers 8
Alejandro C Arroliga
Baylor College of Medicine
Co-authored papers 5
Kelly A Frazer
University of California, USA Institute for Genomic Medicine
Co-authored papers 4
George Q Daley
Boston Children's Hospital, Harvard Medical School
Co-authored papers 4
Christine L Mummery
Leiden University Medical Center
Co-authored papers 3
Roger A Pedersen
Stanford University
Co-authored papers 3
Ge Yang
College of Chemistry, Sichuan University
Co-authored papers 3
Steven P Briggs
Co-authored papers 2
Juan Carlos Izpisua Belmonte
Inc., Salk Institute for Biological Studies
Co-authored papers 2
Gene W Yeo
University of California
Co-authored papers 2
Rudolph E Tanzi
Co-authored papers 2
Jessica M Rusert
University of California San Diego
Co-authored papers 2
Ivan Garcia-Bassets
Co-authored papers 2
Kun Zhang
China Pharmaceutical University
Co-authored papers 2
Heather M Rooke
Broad Institute of Harvard and MIT
Co-authored papers 2
Zhouxin Shen
Co-authored papers 2
Mark H Ellisman
National Center for Microscopy and Imaging Research, University of California
Co-authored papers 2
Marco A Marra
University of British Columbia
Co-authored papers 2
Athurva Gore
Co-authored papers 2
Kim-Hien T Dao
Astex Pharmaceuticals
Co-authored papers 2
William C Mobley
University of California San Diego
Co-authored papers 2
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Insoo Hyun
Center for Bioethics, Harvard Medical School
Co-authored papers 2
Steven L Wagner
Co-authored papers 2
Janet D Marszalek
Co-authored papers 1
Catherine Racowsky
Hospital Foch
Co-authored papers 1
Reed A George
Howard Hughes Medical Institute
Co-authored papers 1
George L Gabor Miklos
Monash University at Cabrini Health
Co-authored papers 1
Nuria Montserrat
Catalan Institution for Research and Advanced Studies (ICREA)
Co-authored papers 1
R F Galle
Co-authored papers 1
Release 1.2