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Author Details

H-J Su Huang
Regeneron Pharmaceuticals Inc.
1994
53
37
PMIDPaper TitleJournal TitlePublished Year
37058568IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models.Sci Adv2023
35928912Effect of Recombinant Netrin-1 Protein Combined with Peripheral Blood Mesenchymal Stem Cells on Angiogenesis in Rats with Arteriosclerosis Obliterans.Biomed Res Int2022
36204132rhCNB Improves Cyclophosphamide-Induced Immunodeficiency in BALB/c Mice.Evid Based Complement Alternat Med2022
20660366KLF6 Gene and early melanoma development in a collagen I-rich extracellular environment.J Natl Cancer Inst2010
12861074Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.Proc Natl Acad Sci U S A2003
12651601Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment.Am J Pathol2003
11770895CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity.Brain Pathol2002
12438278Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas.Cancer Res2002
12065666A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression.J Neurochem2002
11920591Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene.Int J Cancer2002
11164186Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications.Cancer Lett2001
11565870Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor.J Neurosurg2001
11454674Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.Cancer Res2001
11454673Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.Cancer Res2001
11388668The potential of TRAIL for cancer chemotherapy.Apoptosis2001
11514572The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.J Biol Chem2001
10706092Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.Cancer Res2000
11302255SETA: a novel SH3 domain-containing adapter molecule associated with malignancy in astrocytes.Neuro Oncol2000
10896202Analysis of the p300/CBP-Associated Factor (PCAF) gene in astrocytic tumors.J Neurooncol2000
10890917A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin.Proc Natl Acad Sci U S A2000
10554042Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis.Cancer Res1999
10446968The chromosome 10 monosomy common in human melanomas results from loss of two separate tumor suppressor loci.Cancer Res1999
11504467Causes of drug resistance and novel therapeutic opportunities for the treatment of glioblastoma.Drug Resist Updat1999
10197615Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase.Cancer Res1999
10074901Malignant transformation of p53-deficient astrocytes is modulated by environmental cues in vitro.Cell Growth Differ1999
10494560Expression of integrin transcripts in human cancer cells.Methods Mol Biol1999
10527883Identification and validation of tumor suppressor genes.Mol Cell Biol Res Commun1999
9823298The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.Cancer Res1998
9661881Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome.Cancer Res1998
9576951Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases.Proc Natl Acad Sci U S A1998
9829808Expression of vascular endothelial growth factor in human brain tumors.Acta Neuropathol1998
9689095In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma.Proc Natl Acad Sci U S A1998
9039457Expression and distribution of vascular endothelial growth factor protein in human brain tumors.Acta Neuropathol1997
9229142Advances in the molecular genetics of gliomas.Curr Opin Oncol1997
9366518Functional analysis of wild-type and malignant glioma derived CDKN2Abeta alleles: evidence for an RB-independent growth suppressive pathway.Oncogene1997
9356475Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.Proc Natl Acad Sci U S A1997
9342366Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189.Proc Natl Acad Sci U S A1997
9006938The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling.J Biol Chem1997
9053859Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma.Oncogene1997
8625319Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.Cancer Res1996
8895767A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.Cancer Res1996
8817614Molecular biology of malignant degeneration of astrocytoma.Pediatr Neurosurg1996
8810340Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway.J Biol Chem1996
8752145Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors.Cancer Res1996
8806451cAMP effects on myogenic gene expression in rhabdomyosarcoma cells.Exp Cell Res1996
8710899Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor.Proc Natl Acad Sci U S A1996
7862624Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells.Proc Natl Acad Sci U S A1995
8718522Genetics and malignant progression of human brain tumours.Cancer Surv1995
8586466The p53 gene and its role in human brain tumors.Glia1995
7882335Replacement of the p16/CDKN2 gene suppresses human glioma cell growth.Cancer Res1995
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Collaborators

Ludwig Institute for Cancer Research, University of California San Diego
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Kyorin University Faculty of Medicine
Co-authored papers 16
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Co-authored papers 11
American Association for Cancer Research, Henry Ford Hospital, Ludwig Institute for Cancer Research, National Cancer Institute, Salk Institute for Biological Studies, University of Cambridge, University of Texas MD Anderson Cancer Center, Virginia Commonwealth University
Co-authored papers 6
Saitama Medical University International Medical Center
Co-authored papers 6
Rutgers Cancer Institute of New Jersey
Co-authored papers 5
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Northwestern University Feinberg School of Medicine
Co-authored papers 5
Ludwig Institute for Cancer Research
Co-authored papers 3
Telethon Kids Institute
Co-authored papers 3
Heersink School of Medicine, University of Alabama at Birmingham
Co-authored papers 2
Center for Gastroenterology, Teine Keijinkai Hospital
Co-authored papers 2
Co-authored papers 2
Steadman Philippon Research Institute, Center for Regenerative Sports Medicine
Co-authored papers 2
Northwestern University Feinberg School of Medicine
Co-authored papers 2
MD Anderson Cancer Center
Co-authored papers 1
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University Hospital and University of Zurich
Co-authored papers 1
de Duve Institute, Universite catholique de Louvain
Co-authored papers 1
Scripps Memorial Hospital
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Wihuri Research Institute
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University of California san francisco
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Monash University
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Henry Ford Hospital
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University of California san francisco
Co-authored papers 1
Olivia Newton-John Cancer Research Institute
Co-authored papers 1