Author details

Full Name

Gregory A Newby

Affiliation

ORCID

Career Start Year

2013

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37142705	Efficient prime editing in mouse brain, liver and heart with dual AAVs.	Nat Biotechnol	2024
38033325	Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.	Nucleic Acids Res	2024
37169967	A prime editor mouse to model a broad spectrum of somatic mutations in vivo.		2023
36357719	Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity.	Nature Biotechnology	2023
37853259	Author Correction: Efficient Câ¿¢G-to-Gâ¿¢C base editors developed using CRISPRi screens, target-library analysis, and machine learning.		2023
38014346	Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput.		2023
38077224	Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction properties.		2023
37561581	Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy.		2023
38052872	Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo.		2023
37547293	Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells.	Mol Ther Nucleic Acids	2023
37400614	Potent and uniform fetal hemoglobin induction via base editing.	Nat Genet	2023
36824928	Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells .		2023
37137305	Massively parallel base editing to map variant effects in human hematopoiesis.	Cell	2023
37069266	Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice.		2023
36944331	Human TÂ cell generation is restored in CD3Î´ severe combined immunodeficiency through adenine base editing.		2023
36996170	Base editing rescue of spinal muscular atrophy in cells and in mice.		2023
36865281	Multiplex Base Editing to Protect from CD33-Directed Therapy: Implications for Immune and Gene Therapy.		2023
36800642	InÂ vivo HSC prime editing rescues sickle cell disease in a mouse model.		2023
36797483	Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice.	Nat Med	2023
36993169	Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing <i>in vivo</i>.	bioRxiv	2023
34880468	Author Correction: Engineered pegRNAs improve prime editing efficiency.	Nature Biotechnology	2022
35513721	Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells.	Nat Genet	2022
35383196	In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration.	Nat Commun	2022
36006707	In vivo base editing by a single i.v. vector injection for treatment of hemoglobinopathies.	JCI insight	2022
36385635	ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation.	Scientific Reports	2022
34737067	Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human TÂ cells and hematopoietic stem and progenitor cells using base editing.	Molecular Therapy	2022
34608327	Engineered pegRNAs improve prime editing efficiency.	Nature Biotechnology	2022
35021064	Engineered virus-like particles for efficient inÂ vivo delivery of therapeutic proteins.	Cell	2022
34653350	Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.	Cell	2021
34079130	Base editing of haematopoietic stem cells rescues sickle cell disease in mice.	Nature	2021
33462442	Precision genome editing using cytosine and adenine base editors in mammalian cells.		2021
33722289	Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression.	Genome Biol	2021
34183861	Efficient Câ¿¢G-to-Gâ¿¢C base editors developed using CRISPRi screens, target-library analysis, and machine learning.	Nat Biotechnol	2021
33077938	Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing.	Nature Biomedical Engineering	2021
33408413	In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.	Nature	2021
34520545	Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors.	Nucleic Acids Research	2021
34789924	Publisher Correction: Precision genome editing using cytosine and adenine base editors in mammalian cells.		2021
34509669	InÂ vivo somatic cell base editing and prime editing.	Molecular Therapy	2021
31437443	Base Editor Correction of COL7A1 in RecessiveÂ Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs.	J Invest Dermatol	2020
32433547	Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity.	Nat Biotechnol	2020
32433548	Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity.	Nat Biotechnol	2020
32042170	Continuous evolution of SpCas9 variants compatible with non-G PAMs.	Nat Biotechnol	2020
32042165	Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors.	Nature Biotechnology	2020
32332735	Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope.	Nat Commun	2020
32493795	In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness.	Science Translational Medicine	2020
33122854	Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing.	Nature Biomedical Engineering	2020
32905780	Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.	Cell Rep	2020
32783929	Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.	Cell Rep	2020
31332326	Continuous evolution of base editors with expanded target compatibility and improved activity.	Nature Biotechnology	2019
31634902	Search-and-replace genome editing without double-strand breaks or donor DNA.	Nature	2019