Author details

Full Name

Jeffrey C Barrett

Affiliation

ORCID

Career Start Year

2005

Papers

106

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36737450	Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank.		2023
36038634	Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.	Nat Genet	2022
34711957	An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci.	Nat Genet	2021
35634532	Variation at Spike position 142 in SARS-CoV-2 Delta genomes is a technical artifact caused by dropout of a sequencing amplicon.	Wellcome Open Research	2021
33045747	Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.	Nucleic Acids Res	2021
34387545	Patterns of within-host genetic diversity in SARS-CoV-2.	Elife	2021
31145742	Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.	PLoS Genet	2019
30462303	Open Targets Platform: new developments and updates two years on.	Nucleic Acids Res	2019
31092817	Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.	Nat Commun	2019
31227601	Exome-wide assessment of the functional impact and pathogenicity of multinucleotide mutations.	Genome Res	2019
30806694	Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.	JAMA	2019
29795570	Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.	PLoS Genet	2018
30258228	Common genetic variants contribute to risk of rare severe neurodevelopmental disorders.	Nature	2018
30409806	Quantifying the contribution of recessive coding variation to developmental disorders.	Science	2018
30077628	Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease.	Gastroenterology	2018
29562236	De novo mutations in regulatory elements in neurodevelopmental disorders.	Nature	2018
29211899	Exome Sequencing and Genotyping Identify a Rare Variant in NLRP7 Gene Associated With Ulcerative Colitis.	J Crohns Colitis	2018
29323667	Making new genetic diagnoses with old data: iterative reanalysis and reporting from genome-wide data in 1,133 families with developmental disorders.	Genet Med	2018
29801418	Rare-Variant Studies to Complement Genome-Wide Association Studies.	Annual Review of Genomics and Human Genetics	2018
28067910	Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.	Nat Genet	2017
28658209	Fine-mapping inflammatory bowel disease loci to single-variant resolution.	Nature	2017
28317033	Returning genome sequences to research participants: Policy and practice.	Wellcome Open Res	2017
28650482	The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability.	Nat Genet	2017
27899665	Open Targets: a platform for therapeutic target identification and validation.	Nucleic Acids Res	2017
28067908	Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.	Nat Genet	2017
27548312	A reference panel of 64,976 haplotypes for genotype imputation.	Nat Genet	2016
26974950	Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.	Nat Neurosci	2016
26974007	Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.	Nat Genet	2016
27373512	Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families.	Gastroenterology	2016
26829749	HLA class II sequence variants influence tuberculosis risk in populations of European ancestry.	Nat Genet	2016
27479907	Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.	Nat Genet	2016
26490195	Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.	Lancet	2016
27503255	A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.	Nat Commun	2016
26192919	Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.	Nat Genet	2015
25928412	Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer.	BMC Medical Genetics	2015
25751624	Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.	Nat Genet	2015
25671699	Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes.	PLoS Genet	2015
25529582	Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data.	Lancet	2015
25774636	Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.	Nature Genetics	2015
25569741	Characterization of expression quantitative trait loci in the human colon.	Inflammatory Bowel Diseases	2015
25559196	High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.	Nat Genet	2015
26437029	Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families.	Nat Genet	2015
26257098	Understanding inflammatory bowel disease via immunogenetics.	Journal of Autoimmunity	2015
26343388	Class II HLA interactions modulate genetic risk for multiple sclerosis.	Nat Genet	2015
26157023	Strategies for fine-mapping complex traits.	Human Molecular Genetics	2015
26370900	Using human genetics to make new medicines.	Nat Rev Genet	2015
26367797	The UK10K project identifies rare variants in health and disease.	Nature	2015
26238335	High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotyping.	BMC Genomics	2015
25078778	Distribution and medical impact of loss-of-function variants in the Finnish founder population.	PLoS Genet	2014
25372704	Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.	PLoS ONE	2014