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Author Details

Haiyuan Yu
Weill Institute for Cell and Molecular Biology, Cornell University
2001
125
48
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36217030A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.Nat Biotechnol2023
37562413Finding Needles in the Haystack: Strategies for Uncovering Noncoding Regulatory Variants.Annu Rev Genet2023
36945530A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology.bioRxiv2023
37205525Submitochondrial Protein Translocation Upon Stress Inhibits Thermogenic Energy Expenditure.bioRxiv2023
34959033Implications of disease-related mutations at protein-protein interfaces.Curr Opin Struct Biol2022
35804015DNMT1-mediated epigenetic silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability.Oncogene2022
35677070A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19.Res Sq2022
35933009Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis.J Biol Chem2022
36018818Functional genomic assays to annotate enhancer-promoter interactions genome wide.Hum Mol Genet2022
35177836A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers.Nat Biotechnol2022
35139457Deep learning methods for 3D structural proteome and interactome modeling.Curr Opin Struct Biol2022
35298913Advancing discovery of risk-altering variants for complex diseases by functionally informed fine-mapping.Neuron2022
35023286Aging-related cell type-specific pathophysiologic immune responses that exacerbate disease severity in aged COVID-19 patients.Aging Cell2022
34963661A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.Genome Res2022
32866236SAAMBE-SEQ: a sequence-based method for predicting mutation effect on protein-protein binding affinity.Bioinformatics2021
33491328In-depth and 3-dimensional exploration of the budding yeast phosphoproteome.EMBO Rep2021
33791705Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment.bioRxiv2021
33613773Combination of oncolytic adenovirus targeting SATB1 and docetaxel for the treatment of castration-resistant prostate cancer.J Cancer2021
34647422Progress in methodologies and quality-control strategies in protein cross-linking mass spectrometry.Proteomics2021
34408140Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging.Nat Commun2021
34390347Handcuffing intrinsically disordered regions in Mlh1-Pms1 disrupts mismatch repair.Nucleic Acids Res2021
34845387A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations.Nat Methods2021
34108016Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment.Alzheimers Res Ther2021
34103390A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.Life Sci Alliance2021
34018207Structural basis of TRAPPIII-mediated Rab1 activation.EMBO J2021
32398372A massively parallel barcoded sequencing pipeline enables generation of the first ORFeome and interactome map for rice.Proc Natl Acad Sci U S A2020
31839598MaXLinker: Proteome-wide Cross-link Identifications with High Specificity and Sensitivity.Mol Cell Proteomics2020
33032641De novo missense variants disrupting protein-protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types.Mol Autism2020
33075816Variants in RABL2A causing male infertility and ciliopathy.Hum Mol Genet2020
33093574Maximized quantitative phosphoproteomics allows high confidence dissection of the DNA damage signaling network.Sci Rep2020
32719537Genetics of extreme human longevity to guide drug discovery for healthy ageing.Nat Metab2020
32747300Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens.J Biosci Bioeng2020
32994567Structure-based validation can drastically underestimate error rate in proteome-wide cross-linking mass spectrometry studies.Nat Methods2020
32853540BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.Cell Syst2020
32852886Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.EMBO Rep2020
32622269Glucosylation by the Legionella Effector SetA Promotes the Nuclear Localization of the Transcription Factor TFEB.iScience2020
32958950Transcription imparts architecture, function and logic to enhancer units.Nat Genet2020
32272725SAAMBE-3D: Predicting Effect of Mutations on Protein-Protein Interactions.Int J Mol Sci2020
32325033BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.Cell Syst2020
30452312Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica.Biosci Biotechnol Biochem2019
31800700The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro.An Acad Bras Cienc2019
31469829GRAM: A GeneRAlized Model to predict the molecular effect of a non-coding variant in a cell-type specific manner.PLoS Genet2019
31316724Inferring Protein-Protein Interaction Networks From Mass Spectrometry-Based Proteomic Approaches: A Mini-Review.Comput Struct Biotechnol J2019
31515488Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.Nat Commun2019
31125330Leveraging genetic interactions for adverse drug-drug interaction prediction.PLoS Comput Biol2019
31060304Curdepsidones B⁻G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus <i>Curvularia</i> sp. IFB-Z10.Mar Drugs2019
30655675CART cell therapy for prostate cancer: status and promise.Onco Targets Ther2019
29559475Germline Lysine-Specific Demethylase 1 (<i>LSD1/KDM1A</i>) Mutations Confer Susceptibility to Multiple Myeloma.Cancer Res2018
29892012An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.Nat Genet2018
29864900Emerging role of sperm-associated antigen 9 in tumorigenesis.Biomed Pharmacother2018
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Collaborators

Mark Gerstein
Yale University
Co-authored papers 33
Jishnu Das
Co-authored papers 18
Xiaomu Wei
Cornell University
Co-authored papers 13
Marc Vidal
Blavatnik Institute, Harvard Medical School
Co-authored papers 13
Michael Snyder
Stanford University
Co-authored papers 10
Frederick P Roth
University of Toronto
Co-authored papers 10
Marcus B Smolka
Weill Institute for Cell and Molecular Biology, Cornell University
Co-authored papers 7
Jiang Qian
Co-authored papers 7
Yu Xia
College of Information Engineering, Zhejiang University of Technology
Co-authored papers 6
Nicolas Simonis
Co-authored papers 6
Kavitha Venkatesan
Co-authored papers 6
Matthew Mort
Co-authored papers 5
David N Cooper
Institute of Medical Genetics, Cardiff University
Co-authored papers 5
Peter D Stenson
Co-authored papers 5
Alberto Paccanaro
University of London
Co-authored papers 5
Dov Greenbaum
Reichman University (IDC) Herzliya
Co-authored papers 4
Gary D Bader
University of Toronto
Co-authored papers 4
Andrew G Clark
Co-authored papers 4
Ronald Jansen
Memorial Sloan-Kettering Cancer Center
Co-authored papers 4
Andrew Emili
Boston University School of Medicine, Boston University
Co-authored papers 4
Ramy H Malty
University of Toronto, University of Regina
Co-authored papers 3
Xiaofeng Xin
Massachusetts Institute of Technology
Co-authored papers 3
John C Schimenti
Co-authored papers 3
John Parkinson
The Hospital for Sick Children
Co-authored papers 3
Nicolas Bertin
University Bordeaux, CNRS
Co-authored papers 3
Chenwei Lin
Clinical Research Division, Fred Hutchinson Cancer Center
Co-authored papers 3
Kasper Lage
Co-authored papers 3
Charles Boone
University of Toronto
Co-authored papers 3
Christophe Simon
RIKEN Yokohama Institute
Co-authored papers 3
Yuval Kluger
Yale University School of Medicine
Co-authored papers 3
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