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Author Details

Jorge Moscat
1984
193
77
PMIDPaper TitleJournal TitlePublished Year
36525970Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer.Cancer Cell2023
37749092THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.Nat Commun2023
38092754Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.Nat Commun2023
37219625Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?2023
37083323Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures.2023
34895031Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm.Autophagy2022
36035805Air-liquid organotypic assays to investigate cellular crosstalk in the tumor microenvironment of cancer cells.STAR Protocols2022
35501226Protein kinase Cλ/ι in cancer: a contextual balance of time and signals.Trends in Cell Biology2022
35545049The lactate-NAD<sup>+</sup> axis activates cancer-associated fibroblasts by downregulating p62.Cell Rep2022
35169022S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia.J Neurosci2022
34560002PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.Mol Cell2021
33740421Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.Cancer Cell2021
34001883NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.Nature Communications2021
33554135Mouse model of colorectal cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum.STAR Protocols2021
33207226Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.Developmental Cell2021
33268556Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.Cancer Res2020
31690618The complexity of the serine glycine one-carbon pathway in cancer.Journal of Cell Biology2020
32105670NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.Journal of Hepatology2020
32385399The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.Nat Commun2020
32483624Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.Blood2020
33377079An Orthotopic Implantation Mouse Model of Hepatocellular Carcinoma with Underlying Liver Steatosis.STAR Protocols2020
32589943PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.Cancer Cell2020
33088423Deconstructing tumor heterogeneity: the stromal perspective.Oncotarget2020
32686580The interplay between PRKCI/PKCλ/ι, SQSTM1/p62, and autophagy orchestrates the oxidative metabolic response that drives liver cancer.2020
32839596Fructose stimulated de novo lipogenesis is promoted by inflammation.Nat Metab2020
30827887Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.Cancer Cell2019
31735291Serrated Colorectal Cancer: The Road Less Travelled?2019
30581152p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.Cancer Cell2019
31474570The Dual Roles of the Atypical Protein Kinase Cs in Cancer.Cancer Cell2019
29634950Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor.Cancer Cell2018
30552022Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.Immunity2018
30349045ZZ-dependent regulation of p62/SQSTM1 in autophagy.Nature Communications2018
30198373The macroenviromental control of cancer metabolism by p62.Cell Cycle2018
29702207Metabolic reprogramming of the tumor microenvironment by p62 and its partners.2018
29694894The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.Cell Rep2018
29153842Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.Cancer Cell2017
28605656Metabolism shapes the tumor microenvironment.Current Opinion in Cell Biology2017
28512249p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.Cancer Res2017
28388439Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.Molecular Cell2017
28988820ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.Cell Metab2017
28710122Correction for Linares et al., "Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation".Molecular and Cellular Biology2017
27768885p62 in Cancer: Signaling Adaptor Beyond Autophagy.Cell2016
27058791TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.Molecular Cell2016
26799652Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy2016
26919428NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.Cell2016
27089924Nuclear fallout provides a new link between aPKC and polarized cell trafficking.BMC Biology2016
27211490p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.Cancer Cell2016
26942676TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.Molecular Cell2016
27698189miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3.Cancer Res2016
27653691Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι.Cell Rep2016
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Harvard Medical School
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