Author details

Full Name

Michael J Romanowski

Affiliation

Sunesis Pharmaceuticals, Inc. 395 Oyster Point Boulevard

ORCID

Career Start Year

1993

Papers

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
34314938	Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.	Bioorg Med Chem	2021
34515462	Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8.	ACS Chem Biol	2021
31138459	Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.	Bioorg Med Chem	2019
31209353	A small-molecule inhibitor of C5 complement protein.	Nat Chem Biol	2019
31072929	Structure of lipoprotein lipase in complex with GPIHBP1.	Proc Natl Acad Sci U S A	2019
29475084	Full-length myocilin protein is purified from mammalian cells as a dimer.	Protein Expr Purif	2018
22833538	Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1Î².	Hum Mutat	2013
21459573	Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.	Bioorg Med Chem Lett	2011
19649632	SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.	Cancer Chemother Pharmacol	2010
20052711	Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.	Protein Sci	2010
19284778	Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.	Biochemistry	2009
19646866	2-Aminobenzimidazoles as potent Aurora kinase inhibitors.	Bioorg Med Chem Lett	2009
19186057	Water-soluble prodrugs of an Aurora kinase inhibitor.	Bioorg Med Chem Lett	2009
18433722	Crystal structure of unphosphorylated STAT3 core fragment.	Biochem Biophys Res Commun	2008
18793847	Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.	Bioorg Med Chem Lett	2008
18790636	Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.	Bioorg Med Chem Lett	2008
18678489	Discovery of a potent and selective aurora kinase inhibitor.	Bioorg Med Chem Lett	2008
18703838	Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands.	Acta Crystallogr D Biol Crystallogr	2008
18590738	An allosteric circuit in caspase-1.	J Mol Biol	2008
18678933	Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2008
17434748	Mouse Aurora A: expression in Escherichia coli and purification.	Protein Expr Purif	2007
16274992	Tethering identifies fragment that yields potent inhibitors of human caspase-1.	Bioorg Med Chem Lett	2006
16682620	A common allosteric site and mechanism in caspases.	Proc Natl Acad Sci U S A	2006
15802232	Malonate-assisted purification of human caspases.	Protein Expr Purif	2005
16511067	Structural analysis of caspase-1 inhibitors derived from Tethering.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2005
15296730	Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.	Structure	2004
12424232	The kinetic mechanism of phosphomevalonate kinase.	J Biol Chem	2003
11948793	Crystal structure of the Escherichia coli SbmC protein that protects cells from the DNA replication inhibitor microcin B17.	Proteins	2002
12011453	Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain.	Proc Natl Acad Sci U S A	2002
12011452	The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6.	Proc Natl Acad Sci U S A	2002
12001237	Crystal structure of the Streptococcus pneumoniae phosphomevalonate kinase, a member of the GHMP kinase superfamily.	Proteins	2002
12001236	Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold.	Proteins	2002
12001235	Crystal structure of the Escherichia coli shikimate kinase I (AroK) that confers sensitivity to mecillinam.	Proteins	2002
11118439	Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells.	J Biol Chem	2001
11698677	Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis.	Proc Natl Acad Sci U S A	2001
8995674	Characterization of the human cytomegalovirus irs1 and trs1 genes: a second immediate-early transcription unit within irs1 whose product antagonizes transcriptional activation.	J Virol	1997
9188653	pIRS1 and pTRS1 are present in human cytomegalovirus virions.	J Virol	1997
8440524	Monoclonal antibody prophylaxis against the in vivo toxicity of ricin in mice.	Immunol Invest	1993

1 - 38 of 38

Guillaume Poncet-Montange

Center for the Development of Therapeutics, Broad Institute of MIT & Harvard

Career Start Year 2007

Number of shared co-authors 1

Lisa M Miller Jenkins

National Cancer Institute, National Institutes of Health

Career Start Year 2005

Number of shared co-authors 0

Tarun Gheyi

New York SGX Research Center for Structural Genomics

Career Start Year 2004

Number of shared co-authors 5

Marc C Deller

Incyte Corporation

Career Start Year 2000

Number of shared co-authors 0

Udupi A Ramagopal

Poornaprajna Institute of Scientific Research (PPISR)

Career Start Year 1998

Number of shared co-authors 3

Jack Taunton

University of California san francisco

Career Start Year 1996

Number of shared co-authors 1

Orly Dym

Weizmann Institute of Science

Career Start Year 1995

Number of shared co-authors 4

Zihe Rao

Nankai University

Career Start Year 1995

Number of shared co-authors 4

James C Whisstock

Monash University

Career Start Year 1994

Number of shared co-authors 1

John G Luz

Beth Israel Deaconess Medical Center and Harvard Medical School

Career Start Year 1994

Number of shared co-authors 4

Diana R Tomchick

University of Texas Southwestern Medical Center

Career Start Year 1993

Number of shared co-authors 1

Hee-Won Park

Kangwon National University College of Medicine

Career Start Year 1993

Number of shared co-authors 4

Manfred Koegl

Boehringer Ingelheim RCV GmbH & Co. KG

Career Start Year 1993

Number of shared co-authors 0

Aw Edith Chan

The Walter and Eliza Hall Institute of Medical Research

Career Start Year 1993

Number of shared co-authors 2

Gye Won Han

Bridge Institute, University of Southern California

Career Start Year 1991

Number of shared co-authors 0

P??r Nordlund

Karolinska Institutet, BioClinicum J6

Career Start Year 1989

Number of shared co-authors 4

Cheryl H Arrowsmith

University of Toronto

Career Start Year 1989

Number of shared co-authors 4

Sirano Dhe-Paganon

Dana-Farber Cancer Institute

Career Start Year 1989

Number of shared co-authors 5

Liang Tong

Columbia University

Career Start Year 1988

Number of shared co-authors 4

Steven C Almo

Albert Einstein College of Medicine

Career Start Year 1988

Number of shared co-authors 7

Kevan M Shokat

University of California San Francisco

Career Start Year 1987

Number of shared co-authors 2

Stuart L Schreiber

Broad Institute

Career Start Year 1985

Number of shared co-authors 0

Aled M Edwards

University of Toronto

Career Start Year 1984

Number of shared co-authors 4

Opher Gileadi

Structural Genomics Consortium Karolinska Institute Stockholm Sweden.

Career Start Year 1984

Number of shared co-authors 4

Stefan Knapp

Institute of Pharmaceutical Chemistry, Goethe University

Career Start Year 1983

Number of shared co-authors 4

John Kuriyan

University of California berkeley

Career Start Year 1982

Number of shared co-authors 2

Tom Alber

University of California berkeley

Career Start Year 1976

Number of shared co-authors 1

Robert J Fletterick

University of California San Francisco

Career Start Year 1971

Number of shared co-authors 1

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 1

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 4

row(s) 1 - 30 of 30

Stephen K Burley

The State University of New Jersey

Co-authored papers 8

Jeffrey B Bonanno

Albert Einstein College of Medicine

Co-authored papers 4

Kristin M Zimmerman

Department of Pharmacotherapy & Outcomes Science

Co-authored papers 3

James A Wells

Department of Pharmaceutical Chemistry, University of California San Francisco

Co-authored papers 3

Elisabeth Mertsching

Co-authored papers 3

Elaine F Remmers

Co-authored papers 1

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 1

F W Studier

Brookhaven National Laboratory

Co-authored papers 1

Narayanan Eswar

University of California at San Francisco

Co-authored papers 1

Valentin A Ilyin

Carnegie Mellon University Qatar

Co-authored papers 1

C Edo

Co-authored papers 1

Peter M Kang

Beth Israel Deaconess Medical Center, Harvard Medical School

Co-authored papers 1

Jadwiga H Kycia

Brookhaven National Laboratory

Co-authored papers 1

Ursula Pieper

University of California san francisco

Co-authored papers 1

Sue Ellen Gerchman

Brookhaven National Laboratory

Co-authored papers 1

1 - 15

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