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Author Details

Philip T Sager
Inc., Canada Cardiovascular Research Institute, Stanford University
1975
232
54
PMIDPaper TitleJournal TitlePublished Year
36610526SGK1 inhibition attenuates the action potential duration in reengineered heart cell models of drug-induced QT prolongation.Heart Rhythm2023
37099628Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2.Europace2023
35182037A Phase 1 Clinical Study Evaluating the Effects of Cenobamate on the QT Interval.Clin Pharmacol Drug Dev2022
36441560First Randomized, Multicenter, Placebo-Controlled Study of Self-Administered Intranasal Etripamil for Acute Conversion of Spontaneous Paroxysmal Supraventricular Tachycardia (NODE-301).Circ Arrhythm Electrophysiol2022
34144104Comparison of Dialysis Unit and Home Blood Pressures: An Observational Cohort Study.Am J Kidney Dis2021
33769493Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it.Cardiovasc Res2021
34214210Electrophysiological and ECG Effects of Perhexiline, a Mixed Cardiac Ion Channel Inhibitor, Evaluated in Nonclinical Assays and in Healthy Subjects.J Clin Pharmacol2021
32500447Methodological and Regulatory Considerations for Updated Guidance on the Pressor Effects of Drugs.Ther Innov Regul Sci2020
30447156Assessment of Multi-Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study.Clin Pharmacol Ther2019
30157676Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting.Ther Innov Regul Sci2019
30247575Cardiovascular Safety During and After Use of Phentermine and Topiramate.J Clin Endocrinol Metab2019
31600125Workshop Report: FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms.Circ Res2019
30907981The Potential Role of the J-T<sub>peak</sub> Interval in Proarrhythmic Cardiac Safety: Current State of the Science From the American College of Clinical Pharmacology and the Cardiac Safety Research Consortium.J Clin Pharmacol2019
29212839BP in Dialysis: Results of a Pilot Study.J Am Soc Nephrol2018
30049309Etripamil Nasal Spray for Rapid Conversion of Supraventricular Tachycardia to Sinus Rhythm.J Am Coll Cardiol2018
30185467In-Center Hemodialysis: Time for a Paradigm Shift.J Am Soc Nephrol2018
29989050Prevalence of CKD, Diabetes, and Hypertension in Rural Tanzania.Kidney Int Rep2018
29870977Association of Intradialytic Hypertension with Left Ventricular Mass in Hypertensive Hemodialysis Patients Enrolled in the Blood Pressure in Dialysis (BID) Study.Kidney Blood Press Res2018
29782553Correction: Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.PLoS One2018
29754667Is there a role for pharmacokinetic/pharmacodynamic-guided dosing for novel oral anticoagulants?Am Heart J2018
29672845Drug-induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy.J Clin Pharmacol2018
29497863Does Altered Uric Acid Metabolism Contribute to Diabetic Kidney Disease Pathophysiology?Curr Diab Rep2018
29603015Effect of ulixertinib, a novel ERK1/2 inhibitor, on the QT/QTc interval in patients with advanced solid tumor malignancies.Cancer Chemother Pharmacol2018
29209907Scientific white paper on concentration-QTc modeling.J Pharmacokinet Pharmacodyn2018
29330761Correction to: Scientific white paper on concentration-QTc modeling.J Pharmacokinet Pharmacodyn2018
28986934Mechanistic Model-Informed Proarrhythmic Risk Assessment of Drugs: Review of the "CiPA" Initiative and Design of a Prospective Clinical Validation Study.Clin Pharmacol Ther2018
27798210Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects.J Antimicrob Chemother2017
28407875Mendelian randomization to establish the causality of uric acid with diabetic nephropathy in type 1 diabetics.Kidney Int2017
28454799Long-term electrocardiographic safety monitoring in clinical drug development: A report from the Cardiac Safety Research Consortium.Am Heart J2017
28151871Antihypertensive medications and risk of death and hospitalizations in US hemodialysis patients: Evidence from a cohort study to inform hypertension treatment practices.Medicine (Baltimore)2017
29064178Low dialysate potassium concentration is associated with prolonged recovery time.Hemodial Int2017
28543601Influence of Meals and Glycemic Changes on QT Interval Dynamics.J Clin Pharmacol2017
28543393Model-Based Evaluation of Exenatide Effects on the QT Interval in Healthy Subjects Following Continuous IV Infusion.J Clin Pharmacol2017
26893184Evolution of strategies to improve preclinical cardiac safety testing.Nat Rev Drug Discov2016
27606498Intradialytic hypotension.Curr Opin Nephrol Hypertens2016
28036334Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block.PLoS One2016
27297854The Cardiac Safety Research Consortium enters its second decade: An invitation to participate.Am Heart J2016
27297852NOAC monitoring, reversal agents, and post-approval safety and effectiveness evaluation: A cardiac safety research consortium think tank.Am Heart J2016
27142425Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND).BMC Genomics2016
27282641The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative - Update on progress.J Pharmacol Toxicol Methods2016
26776538Comparison of Prescribed and Measured Dialysate Sodium: A Quality Improvement Project.Am J Kidney Dis2016
26912057Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events.Cardiovasc Diabetol2016
25819855Cardiovascular Safety Outcome Trials: A meeting report from the Cardiac Safety Research Consortium.Am Heart J2015
30222452Clinical Development Approaches and Statistical Methodologies to Prospectively Assess the Cardiovascular Risk of New Antidiabetic Therapies for Type 2 Diabetes.Ther Innov Regul Sci2015
26305897Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).PLoS Genet2015
26286925Understanding the Recent Increase in Ferritin Levels in United States Dialysis Patients: Potential Impact of Changes in Intravenous Iron and Erythropoiesis-Stimulating Agent Dosing.Clin J Am Soc Nephrol2015
26130617Satisfaction with Care of Patients on Hemodialysis.Clin J Am Soc Nephrol2015
26044252Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes.Circ Res2015
26093861Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium.Am Heart J2015
25914207Electrocardiographic effects of class 1 selective histone deacetylase inhibitor romidepsin.Cancer Med2015
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Collaborators

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Co-authored papers 31
Center for Drug Evaluation and Research
Co-authored papers 15
Texas Biomedical Research Institute
Co-authored papers 10
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National Institute of Diabetes and Digestive and Kidney Diseases
Co-authored papers 8
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Center for Health Research, Kaiser Permanente Northwest
Co-authored papers 5
Co-authored papers 5
Co-authored papers 4
Co-authored papers 4
Co-authored papers 4
Wake Forest School of Medicine.
Co-authored papers 4
Texas Biomedical Research Institute
Co-authored papers 4
Baylor College of Medicine
Co-authored papers 4
Wake Forest University School of Medicine
Co-authored papers 4
Co-authored papers 3
Texas Biomedical Research Institute
Co-authored papers 3
University of Pittsburgh School of Medicine
Co-authored papers 3