Author details

Full Name

Lewis C Cantley

Affiliation

ORCID

Career Start Year

1973

Papers

662

H Index

192

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
38059900	NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.	J Cell Biol	2024
36595567	Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations.		2023
37904985	LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase.		2023
37345956	SARS-CoV-2 hijacks p38Î²/MAPK11 to promote virus replication.	mBio	2023
36715544	LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.		2023
36898968	Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader.		2023
36584631	Development of potent and selective degraders of PI5P4KÎ³.	Eur J Med Chem	2023
37399061	Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma.	Neuro Oncol	2023
37205525	Submitochondrial Protein Translocation Upon Stress Inhibits Thermogenic Energy Expenditure.	bioRxiv	2023
36823351	Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.	Nat Chem Biol	2023
36949200	RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.	Nature	2023
37009701	The Hallmarks of a Cancer Discovery.		2023
36812344	Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in <i>BRCA1 or BRCA2</i>.	Sci Transl Med	2023
36631611	An atlas of substrate specificities for the human serine/threonine kinome.	Nature	2023
37425798	Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response.		2023
36724278	PI5P4KÎ± supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition.	Sci Adv	2023
35139162	Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward.	Am J Clin Nutr	2022
35896818	Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models.	Eur J Clin Nutr	2022
35896750	PI3K drives the de novo synthesis of coenzyme A from vitamin B5.	Nature	2022
35584006	Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma.	Cancer Res	2022
35819845	Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP-Dependent Malic Enzyme 1.	Biochemistry	2022
36282911	Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.	Sci Signal	2022
36282572	A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.	J Clin Invest	2022
36085369	Live cold to grow old? Thermogenesis to fight cancer.	Cell Research	2022
35434236	A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma.	Gynecol Oncol Rep	2022
35941104	Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer.	Nature Communications	2022
35484287	At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy.	Nature Reviews Clinical Oncology	2022
35734085	Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses.	bioRxiv	2022
35614234	Developing dietary interventions as therapy for cancer.	Nature Reviews Cancer	2022
35361954	Altered propionate metabolism contributes to tumour progression and aggressiveness.	Nature Metabolism	2022
36325690	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Mol Cancer Ther	2022
36325685	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Mol Cancer Res	2022
36266345	Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.	Nature Communications	2022
36321306	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Cancer Discov	2022
36321301	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Cancer Epidemiol Biomarkers Prev	2022
36321298	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Cancer Immunol Res	2022
36321294	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Blood Cancer Discov	2022
36321264	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Cancer Res	2022
36317374	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Clin Cancer Res	2022
36317369	The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission.	Cancer Prev Res (Phila)	2022
35294338	Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry.	Elife	2022
35149538	Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer.	Clin Cancer Res	2022
35181748	Author Correction: Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer.	Nat Rev Clin Oncol	2022
35134350	Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb.	Curr Biol	2022
34819622	Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer.	Nat Rev Clin Oncol	2022
35122065	Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis.	Nat Cancer	2021
32449185	Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.	Journal of Comparative Neurology	2021
34179825	FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS.	Nat Cancer	2021
33861966	The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.	Cell	2021
34270944	Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply.	Molecular Cell	2021