Author details

Full Name

Han Chen

Affiliation

ORCID

Career Start Year

2011

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37503089	Metabolomic Profiles of Sleep-Disordered Breathing are Associated with Hypertension and Diabetes Mellitus Development: the HCHS/SOL.	Res Sq	2023
34690355	Exploiting family history in aggregation unit-based genetic association tests.	European Journal of Human Genetics	2022
35822943	Targeted Genome Sequencing Identifies Multiple Rare Variants inÂ Caveolin-1 Associated with Obstructive Sleep Apnea.	Am J Respir Crit Care Med	2022
35810165	Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers.	Nat Commun	2022
35995843	Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations.	Commun Biol	2022
36513073	Correlations between complex human phenotypes vary by genetic background, gender, and environment.	Cell Rep Med	2022
35316615	Family history aggregation unit-based tests to detect rare genetic variant associations with application to the Framingham Heart Study.	American Journal of Human Genetics	2022
35189849	Quantification of an oval optic disc in relation to myopic foveoschisis using swept-source optical coherence tomography.	BMC Ophthalmology	2022
35087136	Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.	Sci Rep	2022
34588469	Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function.	Sci Rep	2021
32310627	COMPARISON OF THE INTERNAL LIMITING MEMBRANE INSERTION TECHNIQUE AND THE INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE WITH VITRECTOMY TO TREAT MACULAR HOLE-ASSOCIATED RETINAL DETACHMENT.	Retina	2021
33859359	Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.	Mol Psychiatry	2021
33907307	Genome-wide association study of neck circumference identifies sex-specific loci independent of generalized adiposity.	Int J Obes (Lond)	2021
34167169	Exome sequence association study of levels and longitudinal change of cardiovascular risk factor phenotypes in European Americans and African Americans from the Atherosclerosis Risk in Communities Study.	Genet Epidemiol	2021
34214102	Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program.	PLoS One	2021
33720349	Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries.	Genetics	2021
34337551	BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion.	HGG Adv	2021
33864366	Genome-wide gene-diet interaction analysis in the UK Biobank identifies novel effects on hemoglobin A1c.	Hum Mol Genet	2021
34446064	Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.	Genome Med	2021
34425752	Estimation of total mediation effect for high-dimensional omics mediators.	BMC Bioinformatics	2021
34695175	GEM: scalable and flexible gene-environment interaction analysis in millions of samples.		2021
31116624	Diagnostic Performance of MALDI-TOF MS Compared to Conventional Microbiological Cultures in Patients with Suspected Endophthalmitis.	Ocular Immunology and Inflammation	2020
31799744	A unified method for rare variant analysis of gene-environment interactions.	Statistics in Medicine	2020
32355786	Association of adjuvant aromatase inhibitor with cataract risk in postmenopausal women with breast cancer.	Annals of Translational Medicine (discontinued)	2020
33031748	A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.	Am J Hum Genet	2020
32864785	Efficient gene-environment interaction tests for large biobank-scale sequencing studies.	Genet Epidemiol	2020
32802960	Tailored duration of adjuvant trastuzumab for human epidermal growth factor receptor 2-positive breast cancer.	npj Precision Oncology	2020
32793663	Interaction of two functional genetic variants LOXL1 rs1048661 and VEGFA rs3025039 on the risk of age-related macular degeneration in Chinese women.	Annals of Translational Medicine (discontinued)	2020
32510982	Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels.	Circ Genom Precis Med	2020
31329242	Genetic association testing using the GENESIS R/Bioconductor package.		2019
31636010	Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI.	eBioMedicine	2019
31719535	Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.	Nat Commun	2019
30460711	A powerful and data-adaptive test for rare-variant-based gene-environment interaction analysis.	Statistics in Medicine	2019
30403821	Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.	Hum Mol Genet	2019
30982610	Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies.	Am J Hum Genet	2019
31054281	Genetic and Clinical Findings in a Large Cohort of Chinese Patients with Suspected Retinitis Pigmentosa.	Ophthalmology	2019
29360107	Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.	Sci Data	2018
30060175	Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.	Hum Mol Genet	2018
29077507	Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.	Am J Respir Cell Mol Biol	2018
29279374	Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.	Proc Natl Acad Sci U S A	2018
28122634	Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.	Genome Biol	2017
28754176	Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment.	Environ Health	2017
28566273	An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.	Diabetes	2017
29257133	Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.	Sci Data	2017
27650483	African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos.	J Am Soc Nephrol	2017
27798093	Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.	Hum Mol Genet	2016
27027516	Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses.	Genet Epidemiol	2016
26977737	Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans.	Am J Respir Crit Care Med	2016
27018471	Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models.	Am J Hum Genet	2016
27416945	Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.	Diabetes	2016