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Author Details

Frank Buchholz
University Hospital Carl Gustav Carus, Technische Universitat (TU) Dresden
1989
155
54
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36453648Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3AmutNPM1mut AMLs.Blood Adv2023
37568590Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer.Cancers (Basel)2023
37158248Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering.Nucleic Acids Res2023
370855393D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma.Nat Commun2023
36934299Precise excision of HTLV-1 provirus with a designer-recombinase.Mol Ther2023
36908010CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability.Small Methods2023
34962618Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.Cell Oncol (Dordr)2022
35802645Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing.Cancer Res2022
35737245Using CRISPR-Cas9 to Dissect Cancer Mutations in Cell Lines.Methods Mol Biol2022
35628596Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model.Int J Mol Sci2022
35523139Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.Cell Stem Cell2022
36575171Prediction of designer-recombinases for DNA editing with generative deep learning.Nat Commun2022
35288457DNA methylation-independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins.Life Sci Alliance2022
34951450Pairing of single mutations yields obligate Cre-type site-specific recombinases.Nucleic Acids Res2022
35242289Conformational dynamics promotes disordered regions from function-dispensable to essential in evolved site-specific DNA recombinases.Comput Struct Biotechnol J2022
35269477RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with <i>DNMT3A</i> Mutations.Cells2022
35058465Correction of a Factor VIII genomic inversion with designer-recombinases.Nat Commun2022
33977944Efficient and gentle delivery of molecules into cells with different elasticity <i>via</i> Progressive Mechanoporation.Lab Chip2021
32384610Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors.Genes (Basel)2020
31782544Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2.EMBO J2020
31745551A heterodimer of evolved designer-recombinases precisely excises a human genomic DNA locus.Nucleic Acids Res2020
33376128The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells.Life Sci Alliance2020
33063451MLLT6 maintains PD-L1 expression and mediates tumor immune resistance.EMBO Rep2020
32814809Nearest-neighbor amino acids of specificity-determining residues influence the activity of engineered Cre-type recombinases.Sci Rep2020
32641823Author Correction: In-cell identification and measurement of RNA-protein interactions.Nat Commun2020
32247864Comparison of GeneChip, nCounter, and Real-Time PCR-Based Gene Expressions Predicting Locoregional Tumor Control after Primary and Postoperative Radiochemotherapy in Head and Neck Squamous Cell Carcinoma.J Mol Diagn2020
30993218Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy.Clin Transl Radiat Oncol2019
31757954In-cell identification and measurement of RNA-protein interactions.Nat Commun2019
31735668A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst.Dev Cell2019
30814272Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis.Life Sci Alliance2019
31015169Repeat FMISO-PET imaging weakly correlates with hypoxia-associated gene expressions for locally advanced HNSCC treated by primary radiochemotherapy.Radiother Oncol2019
31031192Comparative RNAi Screens in Isogenic Human Stem Cells Reveal SMARCA4 as a Differential Regulator.Stem Cell Reports2019
31078796CRISPR/Cas9 as a tool to dissect cancer mutations.Methods2019
29192002MS Western, a Method of Multiplexed Absolute Protein Quantification is a Practical Alternative to Western Blotting.Mol Cell Proteomics2018
30001368Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth.PLoS One2018
30208304Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.Stem Cell Reports2018
29876001STK3 is a therapeutic target for a subset of acute myeloid leukemias.Oncotarget2018
30262904A single reporter mouse line for Vika, Flp, Dre, and Cre-recombination.Sci Rep2018
29364956The long noncoding RNA lncR492 inhibits neural differentiation of murine embryonic stem cells.PLoS One2018
29547717Protein Dynamics in Complex DNA Lesions.Mol Cell2018
29324888Transcription factor Runx1 is pro-neurogenic in adult hippocampal precursor cells.PLoS One2018
29298797Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy.Clin Cancer Res2018
29295747Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC.Radiother Oncol2018
29241531lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1.Cell Rep2017
28171747The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo.Dev Cell2017
28500257ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.EMBO Rep2017
28176777Phylointeractomics reconstructs functional evolution of protein binding.Nat Commun2017
29133879Development of a genetic sensor that eliminates p53 deficient cells.Nat Commun2017
28934476Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA.Nucleic Acids Res2017
29097687Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding.Nat Commun2017
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Collaborators

Maciej Paszkowski-Rogacz
Faculty of Medicine and University Hospital Carl Gustav Carus
Co-authored papers 37
Mirko Theis
Medical Faculty and University Hospital Carl Gustav Carus
Co-authored papers 24
Adrian Francis Stewart
Center for Molecular and Cellular Bioengineering, Technische Universitat Dresden
Co-authored papers 19
Ralf Kittler
McDermott Center for Human Growth and Development.
Co-authored papers 16
Ina Poser
Max Planck Institute of Molecular Cell Biology and Genetics
Co-authored papers 15
Li Ding
Medical Faculty and University Hospital Carl Gustav Carus
Co-authored papers 14
Matthias Mann
Max-Planck Institute of Biochemistry
Co-authored papers 10
Bianca Habermann
Aix Marseille University, CNRS, Turing Center for Living Systems
Co-authored papers 9
Anthony A Hyman
Max Planck Institute of Molecular Cell Biology and Genetics
Co-authored papers 9
Debojyoti Chakraborty
CSIR-Institute of Genomics & Integrative Biology
Co-authored papers 7
Andrej Shevchenko
Max Planck Institute of Molecular Cell Biology and Genetics
Co-authored papers 6
Herbert Schulz
Clinic for Plastic, Otto von Guericke University
Co-authored papers 5
Maria Winzi
University Cancer Center
Co-authored papers 5
Karl Mechtler
IMP-Institute of Molecular Pathology
Co-authored papers 4
Yusuke Toyoda
Institute of Life Science, Kurume University
Co-authored papers 4
Agapios Sachinidis
Institute of Neurophysiology, University of Cologne
Co-authored papers 3
Wolfgang E Berdel
University Hospital Munster
Co-authored papers 3
Karla M Neugebauer
Yale University
Co-authored papers 3
Chunaram Choudhary
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Co-authored papers 3
J??rgen Hescheler
Institute of Neurophysiology, University of Cologne
Co-authored papers 3
Michael Xavier Doss
BioMarin Pharmaceutical Inc.
Co-authored papers 3
Norbert H??bner
Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
Co-authored papers 3
Richard Durbin
University of Cambridge
Co-authored papers 2
Peter S Linsley
8Benaroya Research Institute
Co-authored papers 2
Jaak Vilo
Institute of Computer Science, University of Tartu
Co-authored papers 2
Jean-Karim H??rich??
University of California san francisco
Co-authored papers 2
Igor Ulitsky
Weizmann Institute of Science
Co-authored papers 2
Edith Heard
Institut Curie, PSL Research University, CNRS UMR 5, INSERM U934
Co-authored papers 2
Jan Ellenberg
Institute of Child Health and Human Development
Co-authored papers 2
Ronald Naumann
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Release 1.2