Author details

Full Name

Kim Lewis

Affiliation

ORCID

Career Start Year

1992

Papers

159

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37292624	A new antibiotic from an uncultured bacterium binds to an immutable target.	bioRxiv	2023
37611581	An antibiotic from an uncultured bacterium binds to an immutable target.	Cell	2023
37343362	Corrigendum to "Systematic comparisons between Lyme disease and post-treatment Lyme disease syndrome in the U.S. with administrative claims data".	EBioMedicine	2023
37452045	Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.		2023
37166062	Deletions of DNA in cancer and their possible uses for therapy.		2023
34982597	The Role of Integration Host Factor in Escherichia coli Persister Formation.	mBio	2022
36103517	A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections.	Sci Transl Med	2022
35704446	Total Synthesis of Kibdelomycin.	Angewandte Chemie - International Edition	2022
36163500	Computational identification of a systemic antibiotic for gram-negative bacteria.	Nat Microbiol	2022
35575547	A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP.	mBio	2022
35996001	Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.	Nature Chemical Biology	2022
36194754	Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis.	Journal of the American Chemical Society	2022
36194154	Noise in a Metabolic Pathway Leads to Persister Formation in Mycobacterium tuberculosis.	Microbiology spectrum	2022
35922513	Teixobactin kills bacteria by a two-pronged attack on the cell envelope.	Nature	2022
36452178	Identification of a growth factor required for culturing specific fastidious oral bacteria.	J Oral Microbiol	2022
35316142	An intestinal model captures immunomodulatory properties of the microbiota in inflammation.	Gut Microbes	2022
34937193	Mutasynthetic Production and Antimicrobial Characterization of Darobactin Analogs.	Microbiol Spectr	2021
33854236	The antibiotic darobactin mimics a Î²-strand to inhibit outer membrane insertase.	Nature	2021
33780444	Predicting antimicrobial mechanism-of-action from transcriptomes: A generalizable explainable artificial intelligence approach.	PLoS Comput Biol	2021
33768646	Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin.	Angewandte Chemie - International Edition	2021
33872780	Optimization of heterologous Darobactin A expression and identification of the minimal biosynthetic gene cluster.	Metabolic Engineering	2021
33872303	Bacterial persisters are a stochastically formed subpopulation of low-energy cells.	PLoS Biol	2021
34619078	A selective antibiotic for Lyme disease.	Cell	2021
34485323	Recent Progress in Lyme Disease and Remaining Challenges.	Front Med (Lausanne)	2021
33240251	Pulse Dosing of Antibiotic Enhances Killing of a Biofilm.	Frontiers in Microbiology	2020
32197064	The Science of Antibiotic Discovery.	Cell	2020
31907190	Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling.	Antimicrob Agents Chemother	2020
32045203	A Fluorescent Teixobactin Analogue.	ACS Chemical Biology	2020
32269338	Author Correction: A new antibiotic selectively kills Gram-negative pathogens.	Nature	2020
33705287	At the Crossroads of Bioenergetics and Antibiotic Discovery.	Biochemistry (Moscow)	2020
32994327	A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients.	mBio	2020
32753498	Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis.	mBio	2020
31530676	Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells.	mBio	2019
31747680	A new antibiotic selectively kills Gram-negative pathogens.	Nature	2019
31588734	Ureadepsipeptides as ClpP Activators.	ACS Infectious Diseases	2019
31714906	Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model.	PLoS ONE	2019
30531975	GABA-modulating bacteria of the human gut microbiota.	Nat Microbiol	2019
31235939	Microbes make metabolic mischief by targeting drugs.	Nature	2019
31036919	Publisher Correction: Definitions and guidelines for research on antibiotic persistence.	Nat Rev Microbiol	2019
30980069	Definitions and guidelines for research on antibiotic persistence.	Nat Rev Microbiol	2019
31332172	Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics.	Nature Communications	2019
29629769	Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin.	Journal of Medicinal Chemistry	2018
29941425	A Genetic Determinant of Persister Cell Formation in Bacterial Pathogens.	Journal of Bacteriology	2018
30126963	Identifying Vancomycin as an Effective Antibiotic for Killing Borrelia burgdorferi.	Antimicrobial Agents and Chemotherapy	2018
28174313	ATP-Dependent Persister Formation in Escherichia coli.	mBio	2017
28618261	The Making of a Pathogen.		2017
29262868	Quinones are growth factors for the human gut microbiota.	Microbiome	2017
27896376	Reducing the Bottleneck in Discovery of Novel Antibiotics.	Microb Ecol	2017
28232537	Why tolerance invites resistance.	Science	2017
27823963	New approaches to antimicrobial discovery.	Biochemical Pharmacology	2017