| 36617500 | Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors. | Chemistry | 2023 |
| 37737220 | Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance. | Elife | 2023 |
| 37172592 | Human nuclear hormone receptor activity contributes to malaria parasite liver stage development. | Cell Chem Biol | 2023 |
| 37197802 | Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38. | Br J Pharmacol | 2023 |
| 36888694 | Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. | Sci Transl Med | 2023 |
| 34233174 | The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. | Cell Chem Biol | 2022 |
| 35653481 | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. | Science | 2022 |
| 35600849 | Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer. | Front Pharmacol | 2022 |
| 36260689 | The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple <i>Plasmodium</i> kinases and life cycle stages. | Sci Transl Med | 2022 |
| 35149760 | Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. | Commun Biol | 2022 |
| 34348113 | Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. | Cell Chem Biol | 2022 |
| 34548400 | Design of proteasome inhibitors with oral efficacy in vivo against <i>Plasmodium falciparum</i> and selectivity over the human proteasome. | Proc Natl Acad Sci U S A | 2021 |
| 33715347 | PfMFR3: A Multidrug-Resistant Modulator in <i>Plasmodium falciparum</i>. | ACS Infect Dis | 2021 |
| 33573376 | Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite <i>Plasmodium falciparum</i> and Optimization Efforts. | J Med Chem | 2021 |
| 33648890 | MalDA, Accelerating Malaria Drug Discovery. | Trends Parasitol | 2021 |
| 34523908 | Prioritization of Molecular Targets for Antimalarial Drug Discovery. | ACS Infect Dis | 2021 |
| 32286267 | Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. | Nat Commun | 2020 |
| 31813848 | Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery. | Cell Chem Biol | 2020 |
| 32078764 | Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials. | ACS Infect Dis | 2020 |
| 32359426 | Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity. | Cell Chem Biol | 2020 |
| 31085658 | The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa. | Proc Natl Acad Sci U S A | 2019 |
| 31801884 | In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. | Sci Transl Med | 2019 |
| 29326268 | Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. | Science | 2018 |
| 30655961 | Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing <i>N</i>-Methyl Amino Acids as Antiplasmodial Agents. | ACS Med Chem Lett | 2018 |
| 30523084 | Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. | Science | 2018 |
| 30373366 | Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome. | J Med Chem | 2018 |
| 29464421 | Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies. | J Cheminform | 2018 |
| 29451780 | Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery. | ACS Infect Dis | 2018 |
| 27977118 | Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. | ACS Chem Biol | 2017 |
| 28696697 | Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. | J Med Chem | 2017 |
| 27291296 | Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. | Sci Rep | 2016 |
| 22314229 | Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. | FEBS J | 2012 |
| 9660818 | Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast. | J Biol Chem | 1998 |
| 9037025 | Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. | Proc Natl Acad Sci U S A | 1997 |
| 14555965 | Mutational analysis of the interacting cell death regulators CED-9 and CED-4. | Cell Death Differ | 1997 |
| 9202007 | Structural and functional complementation of an inactive Bcl-2 mutant by Bax truncation. | J Biol Chem | 1997 |
| 9190211 | Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe. | Mol Biol Cell | 1997 |
| 9228018 | FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. | J Biol Chem | 1997 |
| 9388232 | Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. | J Biol Chem | 1997 |
| 9383050 | Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein. | Genetics | 1997 |
| 8846783 | Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. | EMBO J | 1995 |
| 7937842 | Negative regulation of mitosis in fission yeast by catalytically inactive pyp1 and pyp2 mutants. | Proc Natl Acad Sci U S A | 1994 |
| 8256510 | Comparison of the biochemical and biological functions of tyrosine phosphatases from fission yeast, budding yeast and animal cells. | Yeast | 1993 |
| 1378585 | Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris. | Oncogene | 1992 |
| 1448087 | The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. | Mol Cell Biol | 1992 |
| 1707152 | Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates. | Oncogene | 1991 |
| 1849659 | A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. | Proc Natl Acad Sci U S A | 1991 |