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Author Details

Sabine Ottilie
University of California San Diego
1991
47
23
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36617500Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors.Chemistry2023
37737220Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.Elife2023
37172592Human nuclear hormone receptor activity contributes to malaria parasite liver stage development.Cell Chem Biol2023
37197802Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.Br J Pharmacol2023
36888694Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target.Sci Transl Med2023
34233174The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.Cell Chem Biol2022
35653481Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.Science2022
35600849Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer.Front Pharmacol2022
36260689The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple <i>Plasmodium</i> kinases and life cycle stages.Sci Transl Med2022
35149760Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance.Commun Biol2022
34348113Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.Cell Chem Biol2022
34548400Design of proteasome inhibitors with oral efficacy in vivo against <i>Plasmodium falciparum</i> and selectivity over the human proteasome.Proc Natl Acad Sci U S A2021
33715347PfMFR3: A Multidrug-Resistant Modulator in <i>Plasmodium falciparum</i>.ACS Infect Dis2021
33573376Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite <i>Plasmodium falciparum</i> and Optimization Efforts.J Med Chem2021
33648890MalDA, Accelerating Malaria Drug Discovery.Trends Parasitol2021
34523908Prioritization of Molecular Targets for Antimalarial Drug Discovery.ACS Infect Dis2021
32286267Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.Nat Commun2020
31813848Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.Cell Chem Biol2020
32078764Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials.ACS Infect Dis2020
32359426Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.Cell Chem Biol2020
31085658The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa.Proc Natl Acad Sci U S A2019
31801884In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.Sci Transl Med2019
29326268Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.Science2018
30655961Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing <i>N</i>-Methyl Amino Acids as Antiplasmodial Agents.ACS Med Chem Lett2018
30523084Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.Science2018
30373366Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.J Med Chem2018
29464421Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies.J Cheminform2018
29451780Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.ACS Infect Dis2018
27977118Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast.ACS Chem Biol2017
28696697Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.J Med Chem2017
27291296Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor.Sci Rep2016
22314229Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A.FEBS J2012
9660818Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast.J Biol Chem1998
9037025Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.Proc Natl Acad Sci U S A1997
14555965Mutational analysis of the interacting cell death regulators CED-9 and CED-4.Cell Death Differ1997
9202007Structural and functional complementation of an inactive Bcl-2 mutant by Bax truncation.J Biol Chem1997
9190211Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.Mol Biol Cell1997
9228018FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.J Biol Chem1997
9388232Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins.J Biol Chem1997
9383050Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.Genetics1997
8846783Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.EMBO J1995
7937842Negative regulation of mitosis in fission yeast by catalytically inactive pyp1 and pyp2 mutants.Proc Natl Acad Sci U S A1994
8256510Comparison of the biochemical and biological functions of tyrosine phosphatases from fission yeast, budding yeast and animal cells.Yeast1993
1378585Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris.Oncogene1992
1448087The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.Mol Cell Biol1992
1707152Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates.Oncogene1991
1849659A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases.Proc Natl Acad Sci U S A1991
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Collaborators

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Co-authored papers 29
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Co-authored papers 14
The Broad Institute
Co-authored papers 9
Harvard T.H. Chan School of Public Health
Co-authored papers 9
Columbia University Irving Medical Center
Co-authored papers 7
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Co-authored papers 6
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Co-authored papers 6
University of California san francisco
Co-authored papers 6
Chang Gung Memorial Hospital
Co-authored papers 5
University of California
Co-authored papers 5
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Co-authored papers 4
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 4
University of Pittsburgh
Co-authored papers 4
The George Washington University School of Medicine and Health Sciences
Co-authored papers 3
University of California
Co-authored papers 3
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Co-authored papers 3
University of California
Co-authored papers 2
Genomics Institute of the Novartis Research Foundation
Co-authored papers 2
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 2
University of California
Co-authored papers 2
University of Toronto
Co-authored papers 1
University of Toronto
Co-authored papers 1
University of California
Co-authored papers 1
University of Toronto
Co-authored papers 1
Nagoya City University
Co-authored papers 1
University of California
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University of California
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University of California
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University of California San Diego
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