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Author Details

Danica Galoni?? Fujimori
University of California San Francisco
2002
60
29
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36495919Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations.J Mol Biol2023
38014974Angucyclinones rescue PhLOPS<sub>A</sub> antibiotic activity by inhibiting Cfr-dependent antibiotic resistance.mBio2023
37832177Recent developments in catalysis and inhibition of the Jumonji histone demethylases.Curr Opin Struct Biol2023
36948085Chemical tools targeting readers of lysine methylation.Curr Opin Chem Biol2023
37294077Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase.J Med Chem2023
35165456Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.Nat Struct Mol Biol2022
35839775Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.Cell Rep2022
35756531Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides.Chem Sci2022
36371847Editorial overview: Catalysis and regulation: The chemistry of catalysis.Curr Opin Struct Biol2022
35866897First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation.J Med Chem2022
35985635Catching BETs by viruses.Biochim Biophys Acta Gene Regul Mech2022
35015630Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance.Elife2022
33314922Exploring the Ligand Preferences of the PHD1 Domain of Histone Demethylase KDM5A Reveals Tolerance for Modifications of the Q5 Residue of Histone 3.ACS Chem Biol2021
34085241miCLIP-MaPseq Identifies Substrates of Radical SAM RNA-Methylating Enzyme Using Mechanistic Cross-Linking and Mismatch Profiling.Methods Mol Biol2021
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
31989172Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit.Nucleic Acids Res2020
31985200Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A.Biochemistry2020
32758979Domain cross-talk in regulation of histone modifications: Molecular mechanisms and targeting opportunities.Curr Opin Chem Biol2020
32475402Dissecting contributions of catalytic and reader domains in regulation of histone demethylation.Methods Enzymol2020
30626866Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling.Nat Commun2019
31685464<i>cfr</i>(B), <i>cfr</i>(C), and a New <i>cfr</i>-Like Gene, <i>cfr</i>(E), in Clostridium difficile Strains Recovered across Latin America.Antimicrob Agents Chemother2019
29782154miCLIP-MaPseq, a Substrate Identification Approach for Radical SAM RNA Methylating Enzymes.J Am Chem Soc2018
29059606Mutations in RNA methylating enzymes in disease.Curr Opin Chem Biol2017
26699912Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.J Med Chem2016
27902775Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN.PLoS One2016
27614207Editorial overview: Chemical genetics and epigenetics.Curr Opin Chem Biol2016
27357682Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation.Proc Natl Acad Sci U S A2016
27496281Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.Nucleic Acids Res2016
26747609Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C).J Biol Chem2016
25533783Product binding enforces the genomic specificity of a yeast polycomb repressive complex.Cell2015
26323614Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes.J Am Soc Mass Spectrom2015
26496625Functional coupling between writers, erasers and readers of histone and DNA methylation.Curr Opin Struct Biol2015
26253978Radical SAM-Mediated Methylation of Ribosomal RNA.Methods Enzymol2015
25686748Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.Nat Commun2015
23398247Site-specific and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein binding.J Am Chem Soc2013
23835516Radical SAM-mediated methylation reactions.Curr Opin Chem Biol2013
23601638Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase.Chem Biol2013
22208312The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.ACS Chem Biol2012
23088750Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.J Am Chem Soc2012
23085277Protein and nucleic acid methylating enzymes: mechanisms and regulation.Curr Opin Chem Biol2012
21368151RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift.Proc Natl Acad Sci U S A2011
20184321RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA.J Am Chem Soc2010
21168760A novel enzymatic rearrangement.Chem Biol2010
19281171Structural analysis of an open active site conformation of nonheme iron halogenase CytC3.J Am Chem Soc2009
19295524Hypoxia sensing goes gauche.Nat Chem Biol2009
18291314Halogenation strategies in natural product biosynthesis.Chem Biol2008
17209546Characterization of the aminocarboxycyclopropane-forming enzyme CmaC.Biochemistry2007
17967013CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases.J Am Chem Soc2007
17940045Cloning and characterization of the biosynthetic gene cluster for kutznerides.Proc Natl Acad Sci U S A2007
17939667Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the alpha-ketoglutarate-dependent halogenase CytC3 from Streptomyces.J Am Chem Soc2007
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Collaborators

University of California San Francisco
Co-authored papers 6
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 5
University of California san francisco
Co-authored papers 4
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 4
University of California San Francisco
Co-authored papers 3
Gladstone Institute of Virology
Co-authored papers 3
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
University of California san francisco
Co-authored papers 3
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 2
University of California san francisco
Co-authored papers 2
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
College of Medical Veterinary and Life Sciences, University of Glasgow
Co-authored papers 1
Northwestern University
Co-authored papers 1
Management and Science University
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Institute of Mental Health and Woodbridge Hospital
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1
University of California san francisco
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Co-authored papers 1
Buck Institute for Research on Aging
Co-authored papers 1
Stanford University
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Co-authored papers 1
University of California san francisco
Co-authored papers 1
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 1
University of North Carolina
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Quantitative Biosciences Institute (QBI), University of California san francisco
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