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Full Name
Edith Aguilar
Affiliation
the Scripps Research Institute
ORCID
Career Start Year
1990
Papers
60
H Index
33
Expertise
CM4AI Collaborator
PMID
Paper Title
Journal Title
Published Year
37869029
Applications of Deep Learning: Automated Assessment of Vascular Tortuosity in Mouse Models of Oxygen-Induced Retinopathy.
Ophthalmol Sci
2023
35639473
Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration.
JCI Insight
2022
35611927
Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.
Glia
2022
33926775
Interferon-γ inhibits retinal neovascularization in a mouse model of ischemic retinopathy.
Cytokine
2021
32437334
Retinal microglia are critical for subretinal neovascular formation.
JCI Insight
2020
33106407
An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization.
Proc Natl Acad Sci U S A
2020
32780864
CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10.
Invest Ophthalmol Vis Sci
2020
30484883
miR-30a-5p inhibition promotes interaction of Fas<sup>+</sup> endothelial cells and FasL<sup>+</sup> microglia to decrease pathological neovascularization and promote physiological angiogenesis.
Glia
2019
31199961
The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia.
Neurochem Int
2019
27918307
VEGF regulates local inhibitory complement proteins in the eye and kidney.
J Clin Invest
2017
28138561
CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect.
JCI Insight
2017
28356444
Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of β-Catenin Signaling.
Circulation
2017
29263301
Fully automated, deep learning segmentation of oxygen-induced retinopathy images.
JCI Insight
2017
26974308
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
Nat Med
2016
26617478
Global metabolomics reveals metabolic dysregulation in ischemic retinopathy.
Metabolomics
2016
27834402
Macrophages form functional vascular mimicry channels in vivo.
Sci Rep
2016
27270778
Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
Nat Med
2016
27494343
CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy.
Invest Ophthalmol Vis Sci
2016
26880994
iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study.
Stem Cells Int
2016
26978795
Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.
Elife
2016
25651341
Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension.
J Vis Exp
2015
28532369
Angiogenesis and Eye Disease.
Annu Rev Vis Sci
2015
25915585
Neurovascular crosstalk between interneurons and capillaries is required for vision.
J Clin Invest
2015
24705878
Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye.
EMBO Mol Med
2014
24084735
Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting.
J Clin Invest
2013
23093773
Targeted deletion of Vegfa in adult mice induces vision loss.
J Clin Invest
2012
22084310
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye.
J Cell Biol
2011
22355595
Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy.
Sci Rep
2011
19544395
Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy.
Glia
2010
20544853
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina.
Glia
2010
19188685
Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress.
J Clin Invest
2009
18483622
Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits.
J Clin Invest
2008
19007663
Chapter 6. Ocular models of angiogenesis.
Methods Enzymol
2008
17240254
Ocular neovascularization: basic mechanisms and therapeutic advances.
Surv Ophthalmol
2007
17372851
Progenitor cells and retinal angiogenesis.
Angiogenesis
2007
17210921
Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis.
Proc Natl Acad Sci U S A
2007
16639024
T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification.
Invest Ophthalmol Vis Sci
2006
17111048
Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy.
J Clin Invest
2006
16123396
Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease.
Invest Ophthalmol Vis Sci
2005
15098027
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling.
Nat Med
2004
14985324
Global gene expression analysis of the developing postnatal mouse retina.
Invest Ophthalmol Vis Sci
2004
14726407
Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina.
Blood
2004
12742861
Endothelial proliferation in diabetic retinal microaneurysms.
Arch Ophthalmol
2003
12573615
In vivo transduction of photoreceptors or ciliary body by intravitreal injection of pseudotyped adenoviral vectors.
Mol Ther
2003
11856728
Loss of p53 compensates for alpha v-integrin function in retinal neovascularization.
J Biol Chem
2002
12407162
Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion.
Invest Ophthalmol Vis Sci
2002
8597275
Comparative treatment of experimental Staphylococcus aureus endophthalmitis.
Am J Ophthalmol
1996
8909208
Aminoglycoside levels in the rabbit vitreous cavity after intravenous administration.
Am J Ophthalmol
1996
8981699
Intraocular dexamethasone produces a harmful effect on treatment of experimental Staphylococcus aureus endophthalmitis.
Trans Am Ophthalmol Soc
1996
7624605
Vitreous cavity penetration of ceftazidime after intravenous administration.
Retina
1995
1 - 50 of 60
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Collaborators
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the Scripps Research Institute
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Medical Center, University of Freiburg
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10
Kyle V Marra
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4
Marin L Gantner
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Clary B Clish
Broad Institute of MIT and Harvard
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Audra K Johnson
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University of Lausanne
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John P Campbell
Casey Eye Institute, Oregon Health & Science University
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