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Author Details

Edith Aguilar
the Scripps Research Institute
1990
60
33
PMIDPaper TitleJournal TitlePublished Year
37869029Applications of Deep Learning: Automated Assessment of Vascular Tortuosity in Mouse Models of Oxygen-Induced Retinopathy.Ophthalmol Sci2023
35639473Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration.JCI Insight2022
35611927Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis.Glia2022
33926775Interferon-γ inhibits retinal neovascularization in a mouse model of ischemic retinopathy.Cytokine2021
32437334Retinal microglia are critical for subretinal neovascular formation.JCI Insight2020
33106407An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization.Proc Natl Acad Sci U S A2020
32780864CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10.Invest Ophthalmol Vis Sci2020
30484883miR-30a-5p inhibition promotes interaction of Fas<sup>+</sup> endothelial cells and FasL<sup>+</sup> microglia to decrease pathological neovascularization and promote physiological angiogenesis.Glia2019
31199961The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia.Neurochem Int2019
27918307VEGF regulates local inhibitory complement proteins in the eye and kidney.J Clin Invest2017
28138561CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect.JCI Insight2017
28356444Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of β-Catenin Signaling.Circulation2017
29263301Fully automated, deep learning segmentation of oxygen-induced retinopathy images.JCI Insight2017
26974308Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.Nat Med2016
26617478Global metabolomics reveals metabolic dysregulation in ischemic retinopathy.Metabolomics2016
27834402Macrophages form functional vascular mimicry channels in vivo.Sci Rep2016
27270778Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.Nat Med2016
27494343CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy.Invest Ophthalmol Vis Sci2016
26880994iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study.Stem Cells Int2016
26978795Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.Elife2016
25651341Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension.J Vis Exp2015
28532369Angiogenesis and Eye Disease.Annu Rev Vis Sci2015
25915585Neurovascular crosstalk between interneurons and capillaries is required for vision.J Clin Invest2015
24705878Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye.EMBO Mol Med2014
24084735Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting.J Clin Invest2013
23093773Targeted deletion of Vegfa in adult mice induces vision loss.J Clin Invest2012
22084310Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye.J Cell Biol2011
22355595Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy.Sci Rep2011
19544395Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy.Glia2010
20544853Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina.Glia2010
19188685Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress.J Clin Invest2009
18483622Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits.J Clin Invest2008
19007663Chapter 6. Ocular models of angiogenesis.Methods Enzymol2008
17240254Ocular neovascularization: basic mechanisms and therapeutic advances.Surv Ophthalmol2007
17372851Progenitor cells and retinal angiogenesis.Angiogenesis2007
17210921Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis.Proc Natl Acad Sci U S A2007
16639024T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification.Invest Ophthalmol Vis Sci2006
17111048Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy.J Clin Invest2006
16123396Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease.Invest Ophthalmol Vis Sci2005
15098027Regulation of angiogenesis by tissue factor cytoplasmic domain signaling.Nat Med2004
14985324Global gene expression analysis of the developing postnatal mouse retina.Invest Ophthalmol Vis Sci2004
14726407Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina.Blood2004
12742861Endothelial proliferation in diabetic retinal microaneurysms.Arch Ophthalmol2003
12573615In vivo transduction of photoreceptors or ciliary body by intravitreal injection of pseudotyped adenoviral vectors.Mol Ther2003
11856728Loss of p53 compensates for alpha v-integrin function in retinal neovascularization.J Biol Chem2002
12407162Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion.Invest Ophthalmol Vis Sci2002
8597275Comparative treatment of experimental Staphylococcus aureus endophthalmitis.Am J Ophthalmol1996
8909208Aminoglycoside levels in the rabbit vitreous cavity after intravenous administration.Am J Ophthalmol1996
8981699Intraocular dexamethasone produces a harmful effect on treatment of experimental Staphylococcus aureus endophthalmitis.Trans Am Ophthalmol Soc1996
7624605Vitreous cavity penetration of ceftazidime after intravenous administration.Retina1995
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Collaborators

the Scripps Research Institute
Co-authored papers 46
Medical Center, University of Freiburg
Co-authored papers 10
the Scripps Research Institute
Co-authored papers 5
Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Co-authored papers 5
The Scripps Research Institute
Co-authored papers 5
Lowy Medical Research Institute, California The Scripps Research Institute
Co-authored papers 4
Lowy Medical Research Institute
Co-authored papers 4
Broad Institute of MIT and Harvard
Co-authored papers 2
Lowy Medical Research Institute
Co-authored papers 2
UCL Institute of Ophthalmology
Co-authored papers 2
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS)
Co-authored papers 2
Altius Institute for Biomedical Sciences
Co-authored papers 1
UK System Immunity Research Institute, Cardiff University
Co-authored papers 1
University of Washington, Department of Psychology and eScience Institute
Co-authored papers 1
University of Lausanne
Co-authored papers 1
Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
Co-authored papers 1
Casey Eye Institute, Oregon Health & Science University
Co-authored papers 1
McLean Hospital and Program in Neuroscience, Harvard Medical School
Co-authored papers 1
Abramson Family Cancer Research Institute, Perelman School of Medicine
Co-authored papers 1
Lewis-Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 1
Shiley Eye Institute, Rady Children's Hospital, University of California
Co-authored papers 1
Co-authored papers 1
Wills Eye Hospital
Co-authored papers 1
Harvard University, Moorfields Eye Hospital NHS Foundation Trust, St. John's Mercy Hospital, University of British Columbia, University of Washington, Washington University in Saint Louis
Co-authored papers 1
University of Toronto
Co-authored papers 1
University of Washington
Co-authored papers 1
University of Washington
Co-authored papers 1
Co-authored papers 1
National Eye Institute, National Institutes of Health
Co-authored papers 1
Yale School of Public Health
Co-authored papers 1