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Author Details

Peter St George-Hyslop
Cambridge Institute for Medical Research, University of Cambridge
1977
439
101
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36755024Spatially non-uniform condensates emerge from dynamically arrested phase separation.Nat Commun2023
37549257The liquid-to-solid transition of FUS is promoted by the condensate surface.Proc Natl Acad Sci U S A2023
36993242ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.bioRxiv2023
37461624Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies <i>LRRC4C, LHX5-AS1</i> and nominates ancestry-specific loci <i>PTPRK</i> , <i>GRB14</i> , and <i>KIAA0825</i> as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.medRxiv2023
36880288MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease.CNS Neurosci Ther2023
36905253The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs.Alzheimers Dement2023
35153729Does Soluble TREM2 Protect Against Alzheimer's Disease?Front Aging Neurosci2022
35431249Lipid Rafts Act as a Common Platform for Amyloid-β Oligomer-Induced Alzheimer's Disease Pathology.J Alzheimers Dis2022
35394846Z-α<sub>1</sub>-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state.Sci Adv2022
36543777Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.Nat Commun2022
35993436Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2.EMBO J2022
33314529Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.Alzheimers Dement2021
33597515Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.Nat Commun2021
33823153Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.J Biol Chem2021
33589841Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.Nat Genet2021
34428276Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway.Brain2021
34427354Differential interaction with TREM2 modulates microglial uptake of modified Aβ species.Glia2021
32661370Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.Nat Nanotechnol2020
31996268Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies.Acta Neuropathol Commun2020
32071389Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death.Commun Biol2020
32978332Withdrawal: Cytosolic proteins regulate α-synuclein dissociation from presynaptic membranes.J Biol Chem2020
30283031Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.Mol Psychiatry2019
31177217Oral Immunization with Soybean Storage Protein Containing Amyloid-β 4-10 Prevents Spatial Learning Decline.J Alzheimers Dis2019
31580390Genetic and epigenetic study of an Alzheimer's disease family with monozygotic triplets.Brain2019
31575706<i>APOE</i> ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia.Neurology2019
31595953Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins.Hum Mol Genet2019
31618637TET2 Regulates the Neuroinflammatory Response in Microglia.Cell Rep2019
30953760Heritability and genetic variance of dementia with Lewy bodies.Neurobiol Dis2019
30820047Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.Nat Genet2019
30448004A comprehensive screening of copy number variability in dementia with Lewy bodies.Neurobiol Aging2019
29263008Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.Lancet Neurol2018
29930110Analysis of shared heritability in common disorders of the brain.Science2018
30297984Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation.Front Cell Neurosci2018
29782824APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies.Alzheimers Dement2018
29723523The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.Brain Res2018
29459792C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.Nat Commun2018
29656768A rare variant in MLKL confers susceptibility to ApoE ɿ4-negative Alzheimer's disease in Hong Kong Chinese population.Neurobiol Aging2018
29677515FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-Ï¿ Interactions.Cell2018
27743520Characterizing familial corticobasal syndrome due to Alzheimer's disease pathology and PSEN1 mutations.Alzheimers Dement2017
28183528Transethnic genome-wide scan identifies novel Alzheimer's disease loci.Alzheimers Dement2017
28320827Structural and Chemical Biology of Presenilin Complexes.Cold Spring Harb Perspect Med2017
29568692Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age.Brain Behav2017
28855301TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.EMBO Mol Med2017
28852706Ultra-rare mutations in <i>SRCAP</i> segregate in Caribbean Hispanic families with Alzheimer disease.Neurol Genet2017
28619900Deciphering microglial diversity in Alzheimer's disease.Science2017
28714976Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.Nat Genet2017
28628896Cholinergic neuron gene expression differences captured by translational profiling in a mouse model of Alzheimer's disease.Neurobiol Aging2017
27666590Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.Neurobiol Aging2017
25778476A novel Alzheimer disease locus located near the gene encoding tau protein.Mol Psychiatry2016
29263818The ONDRISeq panel: custom-designed next-generation sequencing of genes related to neurodegeneration.NPJ Genom Med2016
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Collaborators

Boston University Chobanian & Avedisian School of Medicine
Co-authored papers 54
Cleveland Institute for Computational Biology, Case Western Reserve University
Co-authored papers 33
Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center
Co-authored papers 26
The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University
Co-authored papers 25
Co-authored papers 24
Co-authored papers 23
Columbia University Irving Medical Center, New York Presbyterian Hospital
Co-authored papers 21
Co-authored papers 21
Mayo Clinic Jacksonville
Co-authored papers 21
Washington University School of Medicine
Co-authored papers 20
National Institute on Aging
Co-authored papers 19
Icahn School of Medicine at Mount Sinai
Co-authored papers 19
Mayo Clinic Florida
Co-authored papers 19
Co-authored papers 18
Washington University School of Medicine
Co-authored papers 17
University of Pennsylvania
Co-authored papers 16
University of California
Co-authored papers 15
Co-authored papers 15
Mayo Clinic
Co-authored papers 15
Brigham Young University
Co-authored papers 15
Indiana University School of Medicine
Co-authored papers 15
National Institute On Aging
Co-authored papers 15
Rush University Medical Center
Co-authored papers 15
Icahn School of Medicine at Mount Sinai
Co-authored papers 14
Mayo Clinic Rochester
Co-authored papers 14
University of Washington School of Medicine
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Mayo Clinic Rochester
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University of Washington
Co-authored papers 13
Co-authored papers 13