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Author Details

Trevor D McKee
University Health Network
2001
53
24
PMIDPaper TitleJournal TitlePublished Year
36810255Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.JCI Insight2023
35242448Deep Learning Accurately Quantifies Plasma Cell Percentages on CD138-Stained Bone Marrow Samples.J Pathol Inform2022
35508166Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche.Immunity2022
35587994Development and Validation of a Digital Analysis Method to Quantify CD3-immunostained T Lymphocytes in Whole Slide Images of Crohn's Disease Biopsies.Appl Immunohistochem Mol Morphol2022
36938084Cytokines and Immune Cell Phenotype in Acute Kidney Injury Associated With Immune Checkpoint Inhibitors.Kidney Int Rep2022
35978831Digital quantitative tissue image analysis of hypoxia in resected pancreatic ductal adenocarcinomas.Front Oncol2022
34312483Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma.Commun Biol2021
33651938Mass Spectrometry Imaging Reveals a Gradient of Cancer-like Metabolic States in the Vicinity of Cancer Not Seen in Morphometric Margins from Microscopy.Anal Chem2021
33762578Inhibition of HECT E3 ligases as potential therapy for COVID-19.Cell Death Dis2021
34425963Acute Kidney Injury in Severe COVID-19 Has Similarities to Sepsis-Associated Kidney Injury: A Multi-Omics Study.Mayo Clin Proc2021
34711609Heterogeneity of Circulating Tumor Cell-Associated Genomic Gains in Breast Cancer and Its Association with the Host Immune Response.Cancer Res2021
32360427Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease.Mol Metab2020
31866087Prognostic influence of tumor microenvironment after hypofractionated radiation and surgery for mesothelioma.J Thorac Cardiovasc Surg2020
32042347Towards extracellular matrix normalization for improved treatment of solid tumors.Theranostics2020
32391125Correction: Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.Oncotarget2020
30983024Evaluation of optimal biopsy location for assessment of histological activity, transcriptomic and immunohistochemical analyses in patients with active Crohn's disease.Aliment Pharmacol Ther2019
31867322Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections.Front Bioeng Biotechnol2019
30093633Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma.Oncogene2019
31371388Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth.J Cell Biol2019
31310580Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes.Am J Physiol Endocrinol Metab2019
29676815Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach.APMIS2018
30135316Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.JCI Insight2018
30004666Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics.ACS Nano2018
29476017Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.Clin Cancer Res2018
29500362Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma.Sci Rep2018
29492210Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.Oncotarget2018
29508889The expression of CD markers in solid tumors: Significance in metastasis and prognostic value.Histol Histopathol2018
29734804Nanoparticle Formulation Derived from Carboxymethyl Cellulose, Polyethylene Glycol, and Cabazitaxel for Chemotherapy Delivery to the Brain.Bioconjug Chem2018
29453322The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.Mol Cancer Res2018
29097943Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models.Contrast Media Mol Imaging2017
29152107Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.Oncotarget2017
27310112Thermosensitive liposomal cisplatin in combination with local hyperthermia results in tumor growth delay and changes in tumor microenvironment in xenograft models of lung carcinoma.J Drug Target2016
28193010Variations in the Abundance of Lipid Biomarker Ions in Mass Spectrometry Images Correlate to Tissue Density.Anal Chem2016
27618721Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay.Stem Cell Reports2016
27959931MATE2 Expression Is Associated with Cancer Cell Response to Metformin.PLoS One2016
27709819Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.Angew Chem Int Ed Engl2016
26659571RANKL blockade prevents and treats aggressive osteosarcomas.Sci Transl Med2015
28447939A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland.Stem Cell Reports2015
25389372Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.Sci Signal2014
24141625Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response.Clin Cancer Res2013
28855967QUANTIFYING NANOPARTICLE TRANSPORT <i>IN VIVO</i> USING HYPERSPECTRAL IMAGING WITH A DORSAL SKINFOLD WINDOW CHAMBER.J Innov Opt Health Sci2012
20516072Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.J Biol Chem2010
20697156Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.J Clin Invest2010
19151720In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.Nat Methods2009
16510565Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.Cancer Res2006
15994941Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.Cancer Res2005
16089171Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.Comp Med2005
14716306Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.Nat Med2004
12754503Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.Nat Med2003
14654530Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.Clin Cancer Res2003
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Collaborators

Rakesh K Jain
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 10
Bradly G Wouters
Princess Margaret Cancer Centre, University Health Network and, University of Toronto
Co-authored papers 10
Rama Khokha
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 7
Paul D Waterhouse
Princess Margaret Cancer Centre/University Health Network
Co-authored papers 4
Robert G Bristow
University of Toronto
Co-authored papers 4
Ravi N Vellanki
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Marianne Koritzinsky
Princess Margaret Cancer Centre University Health Network
Co-authored papers 3
Jos Jonkers
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 2
Ahmed Aman
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 2
David W Hedley
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Michael Milosevic
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Jenna Sykes
St. Michael's Hospital, University of Toronto
Co-authored papers 2
Ming-Sound Tsao
University Health Network, University of Toronto
Co-authored papers 2
Otto Sanchez
Ontario Tech University
Co-authored papers 2
Vipul Jairath
Schulich school of Medicine, Western University.
Co-authored papers 2
Hui Fang
Beihua University
Co-authored papers 2
Gaetano Zafarana
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Alexander G Beristain
BC Children's Hospital Research Institute
Co-authored papers 2
Melania Pintilie
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Shaf Keshavjee
University Health Network, University Health Network and University of Toronto
Co-authored papers 2
Peter Libby
Co-authored papers 1
David R McCready
University of Toronto, University Health Network
Co-authored papers 1
Jing Xu
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
Jeremy A Squire
University of Sao Paulo
Co-authored papers 1
Peter P Liu
Co-authored papers 1
Alan Dal Pra
University of Miami Miller School of Medicine
Co-authored papers 1
Timothy J Triche
Center for Epigenetics, Van Andel Research Institute
Co-authored papers 1
Andrew H Beck
Beth Israel Deaconess Medical Center, Harvard Medical School
Co-authored papers 1
Thomas Kislinger
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Christopher Fladd
Hospital for Sick Children
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Release 1.2