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Author Details

George M Church
Wyss Institute for Biologically Inspired Engineering, Harvard University
2018
50
28
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36264488Perturbation of Gene Regulation by Genome Editing.Methods Mol Biol2023
37398062Geospatially-resolved public-health surveillance via wastewater sequencing.medRxiv2023
35332307Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues.Nat Biomed Eng2022
32958897Extensive germline genome engineering in pigs.Nat Biomed Eng2021
33828272Low-N protein engineering with data-efficient deep learning.Nat Methods2021
33574611Deep diversification of an AAV capsid protein by machine learning.Nat Biotechnol2021
33568518Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses.Sci Transl Med2021
33712564A computer-guided design tool to increase the efficiency of cellular conversions.Nat Commun2021
33482978Delivery of biomacromolecules for therapeutic genome editing.Adv Drug Deliv Rev2021
33509999Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems.Science2021
33755419Ultrasensitive Measurement of Both SARS-CoV-2 RNA and Antibodies from Saliva.Anal Chem2021
33692551Lineage barcoding in mice with homing CRISPR.Nat Protoc2021
33558653Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency.Nat Microbiol2021
34092791L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma.Nat Methods2021
34050182Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning.Nat Commun2021
33257861A comprehensive library of human transcription factors for cell fate engineering.Nat Biotechnol2021
33462496Characterizing the portability of phage-encoded homologous recombination proteins.Nat Chem Biol2021
33370106Multiplex Single-Molecule Kinetics of Nanopore-Coupled Polymerases.ACS Nano2021
33384301In situ genome sequencing resolves DNA sequence and structure in intact biological samples.Science2021
32315033Enabling large-scale genome editing at repetitive elements by reducing DNA nicking.Nucleic Acids Res2020
31860070A haplotype-aware de novo assembly of related individuals using pedigree sequence graph.Bioinformatics2020
31950348αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model.Protein Cell2020
33268865Reprogramming to recover youthful epigenetic information and restore vision.Nature2020
33176869Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions.J Hematol Oncol2020
33067441Photon-directed multiplexed enzymatic DNA synthesis for molecular digital data storage.Nat Commun2020
327195313D mapping and accelerated super-resolution imaging of the human genome using in situ sequencing.Nat Methods2020
32382252Spatial Sequencing: A Perspective.J Biomol Tech2020
30699343REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.Cell Rep2019
31730337Single-Cell CRISPR-Based Lineage Tracing in Mice.Biochemistry2019
31780559Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design.Science2019
31636460Unified rational protein engineering with sequence-based deep representation learning.Nat Methods2019
31713635Rapid in vitro production of single-stranded DNA.Nucleic Acids Res2019
31685628A single combination gene therapy treats multiple age-related diseases.Proc Natl Acad Sci U S A2019
31427819Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues.Nat Biotechnol2019
31537915Data privacy in the age of personal genomics.Nat Biotechnol2019
31591553Author Correction: Data privacy in the age of personal genomics.Nat Biotechnol2019
31112525Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity.JCI Insight2019
30933074Cell-free Protein Expression Using the Rapidly Growing Bacterium Vibrio natriegens.J Vis Exp2019
31160595Terminator-free template-independent enzymatic DNA synthesis for digital information storage.Nat Commun2019
29062088A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans.Nat Microbiol2018
29241002The Future of Multiplexed Eukaryotic Genome Engineering.ACS Chem Biol2018
29301968Engineering posttranslational proofreading to discriminate nonstandard amino acids.Proc Natl Acad Sci U S A2018
29786095High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast.Nat Biotechnol2018
29735666Codon usage of highly expressed genes affects proteome-wide translation efficiency.Proc Natl Acad Sci U S A2018
29379209Spontaneous CRISPR loci generation in vivo by non-canonical spacer integration.Nat Microbiol2018
29440500Adaptive evolution of genomically recoded <i>Escherichia coli</i>.Proc Natl Acad Sci U S A2018
29555762Precise Cas9 targeting enables genomic mutation prevention.Proc Natl Acad Sci U S A2018
30013045An enhanced CRISPR repressor for targeted mammalian gene regulation.Nat Methods2018
30160938Establishing a Cell-Free Vibrio natriegens Expression System.ACS Synth Biol2018
30082754Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators.Nat Commun2018
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Collaborators

Amanda Graveline
Wyss Institute for Biologically Inspired Engineering
Co-authored papers 4
Alejandro Chavez
Co-authored papers 4
Alex H M Ng
GC Therapeutics Inc.
Co-authored papers 4
Andyna Vernet
Wyss Institute for Biologically Inspired Engineering, Harvard University
Co-authored papers 4
Cory Smith
GC Therapeutics Inc.
Co-authored papers 3
Brian J Beliveau
Co-authored papers 3
Elaine T Lim
Co-authored papers 3
Yingleong Chan
Co-authored papers 3
Edward S Boyden
McGovern Institute for Brain Research
Co-authored papers 3
Evan R Daugharthy
Harvard Medical School
Co-authored papers 3
Kian Kalhor
University of California San Diego
Co-authored papers 2
Dennis Grishin
The Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute
Co-authored papers 2
Peng Yin
Wyss Institute for Biologically Inspired Engineering, Harvard University
Co-authored papers 2
Marc G??ell
Universitat Pompeu Fabra
Co-authored papers 2
Kamal Obbad
Harvard University
Co-authored papers 2
John Aach
Harvard Medical School
Co-authored papers 2
Guangping Gao
Co-authored papers 2
James E DiCarlo
Brigham & Women's Hospital and Harvard Medical School
Co-authored papers 2
Aviv Regev
Broad Institute of MIT and Harvard
Co-authored papers 2
Shilpa Garg
University of Copenhagen
Co-authored papers 2
Brian M Turczyk
Wyss Institute for Biologically Inspired Engineering, Harvard University
Co-authored papers 2
Hamid R Kalhor
Sharif University of Technology
Co-authored papers 2
David R Walt
Brigham and Women's Hospital
Co-authored papers 2
Kathleen Leeper
Johns Hopkins University School of Medicine, USA Center for Epigenetics
Co-authored papers 2
Vadim N Gladyshev
Brigham and Women's Hospital
Co-authored papers 1
Li-Huei Tsai
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Co-authored papers 1
Nathan E Lewis
University of California San Diego
Co-authored papers 1
Chih-Chung Kuo
university of california san diego
Co-authored papers 1
Samuel A Inverso
Eccles Institute of Neuroscience, Australian National University
Co-authored papers 1
Jeremy A Miller
Co-authored papers 1
Release 1.2