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Author Details

Methvin Isaac
Ontario Institute for Cancer Research, University Avenue
1997
30
15
PMIDPaper TitleJournal TitlePublished Year
36793435Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.ACS Med Chem Lett2023
34963044Correction to "Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma".J Med Chem2022
34055235Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of <sup>11</sup>C-Labeled ALK2 Inhibitors.ACS Med Chem Lett2021
34589290The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia.Oncoimmunology2021
34662547Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.J Mol Biol2021
34291633Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.J Med Chem2021
32369358Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.J Med Chem2020
32758183Antagonists of the serotonin receptor 5A target human breast tumor initiating cells.BMC Cancer2020
32295120Sorafenib as an Inhibitor of RUVBL2.Biomolecules2020
26952093PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.J Transl Med2016
22160482A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside.Blood2012
23046966Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development.Bioorg Med Chem Lett2012
23074266TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.Sci Signal2012
21303981Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.Cancer Res2011
22014571Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.Cancer Cell2011
22009536Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers.Cancer Res2011
21601509The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms.Drug Resist Updat2011
210679204-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.Bioorg Med Chem Lett2010
19501602Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.Neuropharmacology2009
19818346The anti-epileptic drug lacosamide (Vimpat) has anxiolytic property in rodents.Eur J Pharmacol2009
15638778Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs.Curr Top Med Chem2005
16178734Recent advances in non-competitive mGlu5 receptor antagonists and their potential therapeutic applications.Curr Top Med Chem2005
14643336Design, synthesis and biological activity of novel dimethyl-[2-[6-substituted-indol-1-yl]-ethyl]-amine as potent, selective, and orally-bioavailable 5-HT(1D) agonists.Bioorg Med Chem Lett2003
121611551-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands.Bioorg Med Chem Lett2002
113783575,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors.Bioorg Med Chem Lett2001
16032481Recent advances in 5-HT(1D)-selective agonists.IDrugs2001
109377326-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists.Bioorg Med Chem Lett2000
10853660Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity.Bioorg Med Chem Lett2000
11671726Factors Influencing 1,4-Asymmetric Induction during Indium-Promoted Coupling of Oxygen-Substituted Allylic Bromides to Aldehydes in Aqueous Solution.J Org Chem1997
11671749Diastereoselection during 1,2-Addition of the Allylindium Reagent to alpha-Thia and alpha-Amino Aldehydes in Aqueous and Organic Solvents.J Org Chem1997
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Collaborators

Ontario Institute for Cancer Research, University Avenue
Co-authored papers 13
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 9
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 8
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 8
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 4
University of Perugia
Co-authored papers 4
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 3
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 2
McGill University
Co-authored papers 1
2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital.
Co-authored papers 1
Campbell Family Mental Health Research Institute, University of Toronto
Co-authored papers 1
Princess Margaret Cancer Centre
Co-authored papers 1
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 1
University of Toronto, Canada Mediterranean Institute for Life Sciences
Co-authored papers 1
2Ontario Institute for Cancer Research
Co-authored papers 1
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 1
The Hospital for Sick Children Research Institute
Co-authored papers 1
University Health Network, University of Toronto
Co-authored papers 1
Ontario Institute for Cancer Research, University of Toronto
Co-authored papers 1
University of California los angeles
Co-authored papers 1
McMaster University
Co-authored papers 1
University of Toronto
Co-authored papers 1
Co-authored papers 1
University of Kansas Medical Center
Co-authored papers 1
Princess Margaret Cancer Centre
Co-authored papers 1
University of Toronto
Co-authored papers 1
Princess Margaret Cancer Centre
Co-authored papers 1
Mount Sinai Hospital
Co-authored papers 1
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 1