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Author Details

Mathieu Laplante
Centre de recherche sur le cancer de l'Universite Laval, Universite Laval
2003
69
35
PMIDPaper TitleJournal TitlePublished Year
36535626DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice.Mol Metab2023
35017517The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage.Nat Commun2022
36536135mTORC1 takes control of lysosomal lipid breakdown.Nat Metab2022
35033724Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice.Mol Metab2022
33196296Control of adipogenic commitment by a STAT3-VSTM2A axis.Am J Physiol Endocrinol Metab2021
35419475ZNF768: controlling cellular senescence and proliferation with ten fingers.Mol Cell Oncol2021
34439288ZNF768 Expression Associates with High Proliferative Clinicopathological Features in Lung Adenocarcinoma.Cancers (Basel)2021
34404770ZNF768 links oncogenic RAS to cellular senescence.Nat Commun2021
34541875Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice.Am J Physiol Endocrinol Metab2021
34135321Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.Nat Commun2021
33284090Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice.Am J Physiol Endocrinol Metab2021
32640840Critical importance of dietary methionine and choline in the maintenance of lung homeostasis during normal and cigarette smoke exposure conditions.Am J Physiol Lung Cell Mol Physiol2020
30702343Pharmacological activation of liver X receptor during cigarette smoke exposure adversely affects alveolar macrophages and pulmonary surfactant homeostasis.Am J Physiol Lung Cell Mol Physiol2019
31767170The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.Mol Metab2019
29969188DEPTOR modulates activation responses in CD4<sup>+</sup> T cells and enhances immunoregulation following transplantation.Am J Transplant2019
31391339The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.JCI Insight2019
30862908HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide.Sci Rep2019
30770439PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.Proc Natl Acad Sci U S A2019
29549139Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome.Sci Immunol2018
29897294DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.Physiol Rev2018
30604855Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung.Int J Dev Biol2018
30317185Cytokines promote lipolysis in 3T3-L1 adipocytes through induction of NADPH oxidase 3 expression and superoxide production.J Lipid Res2018
29496744Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure.Diabetes2018
28052263Amplification of Adipogenic Commitment by VSTM2A.Cell Rep2017
28462079Loss of hepatic DEPTOR alters the metabolic transition to fasting.Mol Metab2017
28270767A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.Front Pharmacol2017
29138472Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue.Sci Rep2017
26880548Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice.Elife2016
27876792mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold.Sci Rep2016
27624942The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.Nat Commun2016
27143559Metabolic activity of brown, "beige," and white adipose tissues in response to chronic adrenergic stimulation in male mice.Am J Physiol Endocrinol Metab2016
27097662DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance.Am J Physiol Regul Integr Comp Physiol2016
25159114DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication.J Comp Neurol2015
26909318Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity.Mol Metab2015
26185979The Roles of mTOR Complexes in Lipid Metabolism.Annu Rev Nutr2015
25681456In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis.FASEB J2015
24936254Interrelationships between ghrelin, insulin and glucose homeostasis: Physiological relevance.World J Diabetes2014
25352671A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.Proc Natl Acad Sci U S A2014
24740015Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.PLoS One2014
23641065Regulation of mTORC1 and its impact on gene expression at a glance.J Cell Sci2013
23658371A comparative perspective on lipid storage in animals.J Cell Sci2013
22129599mTOR Signaling.Cold Spring Harb Perspect Biol2012
22883231DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.Cell Metab2012
22449814Connecting mTORC1 signaling to SREBP-1 activation.Curr Opin Lipidol2012
22500797mTOR signaling in growth control and disease.Cell2012
22410287Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway.Mol Cell Endocrinol2012
19766266Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet.Metabolism2010
21179166mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.Nature2010
20167806mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.Proc Natl Acad Sci U S A2010
18971352Tissue-specific postprandial clearance is the major determinant of PPARgamma-induced triglyceride lowering in the rat.Am J Physiol Regul Integr Comp Physiol2009
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Collaborators

Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 14
Boston Children's Hospital
Co-authored papers 2
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval
Co-authored papers 2
National Institutes of Health/National Institute of Environmental Health Sciences
Co-authored papers 1
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Co-authored papers 1
Spanish National Cancer Research Centre (CNIO)
Co-authored papers 1
McGill University
Co-authored papers 1
Centre Integre Universitaire de Sante et Services Sociaux de la Capitale-Nationale
Co-authored papers 1
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Co-authored papers 1
Botnar Research Centre, University of Oxford
Co-authored papers 1
Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Centre Hospitalier Universitaire de Nantes, Nantes Universite, Inserm
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
University of California berkeley
Co-authored papers 1
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Englander Institute for Precision Medicine
Co-authored papers 1
Boston Children's Hospital, Seoul National University, Seoul National University Hospital
Co-authored papers 1