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Author Details

Jeffrey R Johnson
Gladstone Institutes
2001
86
46
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37019383Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.Mol Cell Proteomics2023
37291385Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.Nat Immunol2023
35263596The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity.Cell Rep2022
35695185DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.Development2022
35266954The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.J Cell Biol2022
34166681Endosomal cAMP production broadly impacts the cellular phosphoproteome.J Biol Chem2021
33854239The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.Nature2021
33536176Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity <i>Ex Vivo and In Vivo</i>.J Virol2021
33502312SUMO is a pervasive regulator of meiosis.Elife2021
32511357A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals.bioRxiv2020
31951200Dynamic post-translational modification profiling of <i>Mycobacterium tuberculosis</i>-infected primary macrophages.Elife2020
32707573Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.Nature2020
32641828Envelope protein ubiquitination drives entry and pathogenesis of Zika virus.Nature2020
30508698Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status.Redox Biol2019
31527793Enterovirus pathogenesis requires the host methyltransferase SETD3.Nat Microbiol2019
31239378Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.mBio2019
31311869PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.Proc Natl Acad Sci U S A2019
31196146Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation.J Exp Clin Cancer Res2019
31101715Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.Proc Natl Acad Sci U S A2019
30814119Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis.Development2019
30833725Identification of antiviral roles for the exon-junction complex and nonsense-mediated decay in flaviviral infection.Nat Microbiol2019
31060926SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1.Mol Metab2019
30883359Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.J Alzheimers Dis2019
31054975Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.Mol Cell2019
29191913Metabolic reprogramming of human CD8<sup>+</sup> memory T cells through loss of SIRT1.J Exp Med2018
30166453CRL4<sup>AMBRA1</sup> targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.EMBO J2018
30209081Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.Cancer Discov2018
30118682An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses.Mol Cell2018
30174294Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease.Mol Cell2018
30377154The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1.G3 (Bethesda)2018
30547882Genetic analysis reveals functions of atypical polyubiquitin chains.Elife2018
29540553SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.J Neurosci2018
28072389Suppression of <i>C9orf72</i> RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.Elife2017
28252385<i>Chlamydia</i> interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.Elife2017
28494238SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.Cell Host Microbe2017
28345603PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.Sci Rep2017
29257953Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.Dev Cell2017
28515293Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling.J Virol2017
28537707The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling.ACS Infect Dis2017
28679761The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.J Virol2017
27879340G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands.Mol Pharmacol2017
27253329Non-degradative Ubiquitination of Protein Kinases.PLoS Comput Biol2016
27974163Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.Neuron2016
27145134A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa.Mol Microbiol2016
25381059Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1.Mol Cell Proteomics2015
26297806Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.Elife2015
26651948Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.Cell Host Microbe2015
26504226Discovery and functional characterization of a neomorphic PTEN mutation.Proc Natl Acad Sci U S A2015
26312481Prediction of Functionally Important Phospho-Regulatory Events in Xenopus laevis Oocytes.PLoS Comput Biol2015
26390242Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.Nat Med2015
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Collaborators

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Sanford Burnham Prebys Medical Discovery Institute
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Sumit K Chanda
The Scripps Research Institute
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Adolfo Garc??a-Sastre
Icahn School of Medicine at Mount Sinai
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Paul D De Jesus
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 3
Ryan D Hernandez
University of California san francisco
Co-authored papers 3
Neil L Kelleher
Northwestern University
Co-authored papers 3
Oren S Rosenberg
University of California san francisco
Co-authored papers 3
Maria I Giraldo
University of Texas Medical Branch
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Eric Verdin
Buck Institute for Research on Aging
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Jeremy F Reiter
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