Author details

Full Name

Paul D Gardner

Affiliation

ORCID

Career Start Year

1987

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
32800629	Midbrain Dopamine Controls Anxiety-like Behavior by Engaging Unique Interpeduncular Nucleus Microcircuitry.	Biological Psychiatry	2020
31965003	Integrated miRNA-/mRNA-Seq of the Habenulo-Interpeduncular Circuit During Acute Nicotine Withdrawal.	Sci Rep	2020
28196335	Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring.	Elife	2017
28714952	A circuit-based mechanism underlying familiarity signaling and the preference for novelty.	Nature Neuroscience	2017
26324408	5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking.		2016
27020042	Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors.	Neuropharmacology	2016
26702833	Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome.	Dev Cell	2015
25898242	Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.	Nat Commun	2015
26133887	Corrigendum: Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.	Nat Commun	2015
26041923	Functional Upregulation of Î±4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward.	Journal of Neuroscience	2015
24184162	Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival.	Molecular and Cellular Neurosciences	2014
25344397	miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family.	RNA	2014
25467983	Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition.	Neuron	2014
23141806	Nicotinic acetylcholine receptors containing the Î±4 subunit modulate alcohol reward.	Biological Psychiatry	2013
23864674	Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia.	Journal of Neuroscience	2013
24062692	Nicotinic acetylcholine receptors mediate lung cancer growth.	Frontiers in Physiology	2013
24239118	Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms.	Current Biology	2013
22222765	Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing Î±4 and Î±6 subunits.	Molecular Pharmacology	2012
21931655	Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma.	PLoS ONE	2011
21289604	Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area.		2011
21239887	Nicotinic acetylcholine receptors containing the Î±4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption.	Channels	2011
21640716	Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.	Biochemical Pharmacology	2011
20668200	Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption.	Journal of Neuroscience	2010
19720621	Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism.	FASEB Journal	2010
20696214	A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo.	Neuroscience	2010
20685379	The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.	Progress in Neurobiology	2010
20124469	ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.	Molecular Cancer Research	2010
20096338	Temporally- and spatially-regulated transcriptional activity of the nicotinic acetylcholine receptor beta4 subunit gene promoter.	Neuroscience	2010
20581870	From smoking to lung cancer: the CHRNA5/A3/B4 connection.	Oncogene	2010
19304657	The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10.	Journal of Biological Chemistry	2009
18382288	Transcription factor assembly on the nicotinic receptor beta4 subunit gene promoter.	NeuroReport	2008
19014486	Nlz1/Znf703 acts as a repressor of transcription.	BMC Developmental Biology	2008
17504758	Transcriptional repression by a conserved intronic sequence in the nicotinic receptor alpha3 subunit gene.	Journal of Biological Chemistry	2007
16488668	Cell-type-specific and developmental regulation of heterogeneous nuclear ribonucleoprotein K mRNA in the rat nervous system.	Gene Expression Patterns	2006
11262397	The signal transduction pathway underlying ion channel gene regulation by SP1-C-Jun interactions.	Journal of Biological Chemistry	2001
10771000	Interactions between regulatory proteins that bind to the nicotinic receptor beta4 subunit gene promoter.	European Journal of Pharmacology	2000
11044731	Synergistic transcriptional activation by Sox10 and Sp1 family members.	Neuropharmacology	2000
10559384	Cell type-specific activation of neuronal nicotinic acetylcholine receptor subunit genes by Sox10.	Journal of Neuroscience	1999
9677424	Differential effects of heterogeneous nuclear ribonucleoprotein K on Sp1- and Sp3-mediated transcriptional activation of a neuronal nicotinic acetylcholine receptor promoter.	Journal of Biological Chemistry	1998
9169473	Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes. A possible role for the DNA-binding protein Puralpha.	Journal of Biological Chemistry	1997
9325332	Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor beta4 subunit gene.	Journal of Biological Chemistry	1997
8955122	Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes. Functional interactions between Sp1 and the rat beta4 subunit gene promoter.	Journal of Biological Chemistry	1996
7876217	A novel regulatory element of a nicotinic acetylcholine receptor gene interacts with a DNA binding activity enriched in rat brain.	Journal of Biological Chemistry	1995
7595943	Differential expression of sodium channels and nicotinic acetylcholine receptor channels in nnr variants of the PC12 pheochromocytoma cell line.	Journal of Membrane Biology	1995
7729578	Electrical activity suppresses nicotinic acetylcholine receptor gamma subunit promoter activity.	Developmental Biology	1995
8120617	Nerve growth factor increases nicotinic ACh receptor gene expression and current density in wild-type and protein kinase A-deficient PC12 cells.	Journal of Neuroscience	1994
7505316	Nerve growth factor increases the transcriptional activity of the rat neuronal nicotinic acetylcholine receptor beta 4 subunit promoter in transfected PC12 cells.	Journal of Neurochemistry	1994
8394227	Potential role of helix-loop-helix proteins in cardiac gene expression.	Circ Res	1993
8226328	Localization of preproenkephalin mRNA-expressing cells in rat auditory brainstem with in situ hybridization.	Hearing Research	1993
1703661	ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kildalton protein.	Science	1991