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Author Details

Opher Gileadi
Structural Genomics Consortium Karolinska Institute Stockholm Sweden.
1984
104
43
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37292860Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease.bioRxiv2023
37547005Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.bioRxiv2023
37215505Open drug discovery in Alzheimer's disease.Alzheimers Dement (N Y)2023
35600892FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in <i>Drosophila</i> S2 Cells.Front Bioeng Biotechnol2022
33125643Screening and Production of Recombinant Human Proteins: Ligation-Independent Cloning.Methods Mol Biol2021
34860543FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.Sci Adv2021
34381037Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.Nat Commun2021
34387696Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.Nucleic Acids Res2021
34387694A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.Nucleic Acids Res2021
33125645Screening and Production of Recombinant Human Proteins: Protein Production in Insect Cells.Methods Mol Biol2021
33125644Screening and Production of Recombinant Human Proteins: Protein Production in E. coli.Methods Mol Biol2021
32467316STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.Life Sci Alliance2020
31914405The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.J Biol Chem2020
33199508Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.Life Sci Alliance2020
33095241RecQ helicases in DNA repair and cancer targets.Essays Biochem2020
32866775The SNM1A DNA repair nuclease.DNA Repair (Amst)2020
30605688WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.Cell Rep2019
31712618Binding and structural analyses of potent inhibitors of the human Ca<sup>2+</sup>/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.Sci Rep2019
32184967SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.ACS Med Chem Lett2019
31531195Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.ACS Med Chem Lett2019
31612854Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.Elife2019
31204252A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.Structure2019
31250316Streamlining the production of proteins for structural biology.Biophys Rev2019
31620147The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity.Front Plant Sci2019
30853107Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.Pathology2019
29291391Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.J Mol Biol2018
30287839Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.Sci Rep2018
28603531Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment.Front Plant Sci2017
28100692Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.Nucleic Acids Res2017
28470595Recombinant Protein Expression in E. coli : A Historical Perspective.Methods Mol Biol2017
29118096The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.Essays Biochem2017
28767711Progress towards a public chemogenomic set for protein kinases and a call for contributions.PLoS One2017
28790404Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.Sci Rep2017
26826708Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease.Nucleic Acids Res2016
27871366Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.Mol Cell2016
27121860Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.Chem Commun (Camb)2016
26807646EXD2 promotes homologous recombination by facilitating DNA end resection.Nat Cell Biol2016
26910052Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.PLoS One2016
25505141CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.Nucleic Acids Res2015
26482303Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.Antimicrob Agents Chemother2015
26582912The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.Nucleic Acids Res2015
26636256Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.Structure2015
25866208Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.J Biol Chem2015
25831490Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.Proc Natl Acad Sci U S A2015
25901030Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.Nucleic Acids Res2015
25670864Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2.J Biol Chem2015
24203324Medium-throughput production of recombinant human proteins: ligation-independent cloning.Methods Mol Biol2014
25418155Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.Nat Commun2014
24450640Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.Biochem Soc Trans2014
24450636Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.Biochem Soc Trans2014
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Collaborators

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Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 2
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Emory University School of Medicine
Co-authored papers 2
Rensselaer Polytechnic Institute
Co-authored papers 2
Tufts University School of Medicine
Co-authored papers 2
University of Toronto
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The University of Edinburgh
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Brookhaven National Laboratory
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