|
| 36727211 | Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. | J Med Chem | 2023 |
| 36912782 | Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners. | Mol Cancer Ther | 2023 |
| 34890209 | Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes. | Mol Pharm | 2022 |
| 34126115 | Generation of High-Quality Pharmacokinetic Data From Parallel Tail Vein Dosing And Bleeding in Non-cannulated Rats. | J Pharm Sci | 2021 |
| 33495510 | Design and optimisation of dendrimer-conjugated Bcl-2/x<sub>L</sub> inhibitor, AZD0466, with improved therapeutic index for cancer therapy. | Commun Biol | 2021 |
| 32988967 | AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia. | Clin Cancer Res | 2020 |
| 33335676 | Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833. | ACS Med Chem Lett | 2020 |
| 32910656 | Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist. | J Med Chem | 2020 |
| 30408457 | Development of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization. | Anal Biochem | 2019 |
| 30640465 | Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists. | J Med Chem | 2019 |
| 29191131 | Efficacy of ceftazidime-avibactam in a rat intra-abdominal abscess model against a ceftazidime- and meropenem-resistant isolate of Klebsiella pneumoniae carrying bla<sub>KPC-2</sub>. | J Chemother | 2018 |
| 28714680 | Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. | J Med Chem | 2017 |
| 28485934 | Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. | J Med Chem | 2017 |
| 28986473 | Mouse Red Blood Cell-Mediated Rare Xenobiotic Phosphorylation of a Drug Molecule Not Intended to Be a Kinase Substrate. | Drug Metab Dispos | 2017 |
| 27149898 | Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole. | Drug Metab Dispos | 2016 |
| 26652586 | Bioanalytical method validation for the simultaneous determination of ceftazidime and avibactam in rat plasma. | Bioanalysis | 2016 |
| 25953419 | Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors. | J Med Chem | 2015 |
| 23415679 | Assessment of cisplatin-induced kidney injury using an integrated rodent platform. | Toxicol Appl Pharmacol | 2013 |
| 22177783 | Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes. | Bioorg Med Chem Lett | 2012 |
| 22812377 | Antibiotic optimization and chemical structure stabilization of thiomuracin A. | J Med Chem | 2012 |
| 22908966 | In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound. | ACS Chem Biol | 2012 |
| 21295471 | A new structural alert for benzimidazoles: 2,6-dimethylphenyl substituents increase mutagenic potential and time-dependent CYP3A4 inhibition risk. | Bioorg Med Chem Lett | 2011 |
| 21999529 | Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids. | J Med Chem | 2011 |
| 21825297 | In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. | Antimicrob Agents Chemother | 2011 |
| 12458929 | Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry. | J Chromatogr A | 2002 |
| 11403278 | Detection of in vivo formed DNA adducts at the part-per-billion level by capillary liquid chromatography/microelectrospray mass spectrometry. | Anal Chem | 2001 |
| 11774901 | Reduction of signal suppression effects in ESI-MS using a nanosplitting device. | Anal Chem | 2001 |
| 10826682 | Subatmospheric electrospray interface for coupling of microcolumn separations with mass spectrometry. | Electrophoresis | 2000 |
| 10525280 | Determination of in vitro- and in vivo-formed DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline by capillary liquid chromatography/microelectrospray mass spectrometry. | Chem Res Toxicol | 1999 |
| 9616191 | Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir. | Drug Metab Dispos | 1998 |